A5004546135- Barrier Structure and Function Studies
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Inflammatory Bowel Disease
- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Wnt/β-catenin signaling in development and cancer
- Lipid metabolism and disorders
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Microscopic Colitis
- Curcumin's Biomedical Applications
- Genetic factors in colorectal cancer
- Hedgehog Signaling Pathway Studies
- Diet and metabolism studies
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Pharmacological Effects of Natural Compounds
- Cell death mechanisms and regulation
- Clostridium difficile and Clostridium perfringens research
- Digestive system and related health
University of Nebraska Medical Center
2015-2024
VA Nebraska Western Iowa Health Care System
2015-2024
Nebraska Medical Center
2016-2023
University of Minnesota
2020
UCLouvain Saint-Louis Brussels
2020
Al Nahdha Hospital
2020
Dr. Rajendra Prasad Government Medical College
2015
Vanderbilt University
2004-2014
Vanderbilt University Medical Center
2006-2014
Northwestern University
2007
Renal tubule epithelia represent the primary site of damage in acute kidney injury (AKI), a process initiated and propagated by infiltration macrophages. Here we investigated role resident renal macrophages dendritic cells recovery from AKI after ischemia/reperfusion (I/R) or novel diphtheria toxin–induced (DT-induced) model selective proximal mice. DT-induced was characterized marked tubular cell apoptosis. In both models, macrophage/dendritic depletion during phase increased functional...
<h3>Objective</h3> Claudin-1 expression is increased and dysregulated in colorectal cancer causally associates with the dedifferentiation of colonic epithelial cells, progression metastasis. Here, we have sought to determine role claudin-1 plays regulation intestinal homeostasis. <h3>Design</h3> We used a novel villin-claudin-1 transgenic (Cl-1Tg) mouse as model (with overexpression). The effect upon differentiation, lineage commitment Notch-signalling was determined using...
Tight junctions are the apical cell-cell adhesion that regulate paracellular permeability and critical for epithelial cell polarity. Molecular architecture of tight junction has been studied extensively, which confirmed claudin family proteins is integral component junction. Loss central to cellular transformation acquisition metastatic potential; however, role play in a series pathophysiological events, including human carcinoma development, only now beginning be understood. Several mouse...
Tight junctions (TJs) are the most apical cell-cell junctions, and claudins, recently identified TJ proteins, critical for maintaining adhesion in epithelial cell sheets. Based on their vivo distribution results of overexpression studies, certain including claudin-1 -4, postulated to increase, whereas other especially claudin-2, decrease overall transcellular resistance. The ratio among claudins expressed a cell/tissue has been hypothesized define complexity TJs. Disruption TJs contributes...
Obesity increases susceptibility to multiple organ disorders, however, underlying mechanisms remain unclear. The subclinical inflammation assisted by obesity-induced gut permeability may underlie obesity-associated co-morbidities. Despite eminent clinical significance of the obesity led barrier abnormalities, its precise molecular regulation remains It is also unknown whether deregulations, similar gut, characterize other vital organs in obese individuals. claudin family proteins integral...
Patients suffering from ulcerative colitis (UC) exhibit chronic colonic inflammation caused by a dysregulated mucosal immune response and epithelial barrier disruption. Th2 cytokines, including IL-13, have been implicated in the pathogenesis of UC. IL-13 induces phosphorylation STAT6, we previously demonstrated increased p-STAT6 children with In this study, investigated role STAT6 oxazolone colitis, murine model UC, inducing STAT6-deficient (STAT6(-/-)) wild type (WT) mice. We observed cell,...
The tight junction protein Claudin-1, a claudin family member, has been implicated in several gastro-intestinal pathologies including inflammatory bowel disease (IBD) and colorectal cancer (CRC). In this regard, we have demonstrated that claudin-1 expression colon cells potentiates their tumorigenic ability while vivo of the intestinal epithelial (IECs) promotes Notch-activation, inhibits goblet cell differentiation renders susceptibility to mucosal inflammation. Notably, key role...
Denial of the appropriate cell-matrix interaction in epithelial cells induces apoptosis and is called 'anoikis'. Cancer are resistant to anoikis it believed that resistance helps promote tumor malignancy especially metastasis. We others have demonstrated expression tight junction protein claudin-1 highly upregulated colorectal cancer (CRC) progression However, molecular mechanism/s underlying claudin-1-dependent regulation CRC remains poorly understood. In current study, we determined...
Chemotherapeutic agents that modulate cell cycle checkpoints and/or tumor-specific pathways have shown immense promise in preclinical and clinical studies aimed at anti-cancer therapy. MASTL (Greatwall Xenopus Drosophila), a serine/threonine kinase controls the final G2/M checkpoint prevents premature entry of cells into mitosis. Recent suggest expression is highly upregulated cancer confers resistance against chemotherapy. However, role mechanism/s mediated regulation tumorigenesis remains...
Abstract Cocaine use disorder (CUD), a major health crisis, has traditionally been considered complication of the CNS; however, it is also closely associated with malnourishment and deteriorating gut health. In light emerging studies on potential role microbiota in neurological disorders, we sought to understand causal association between CUD dysbiosis. Using comprehensive approach, confirmed that cocaine administration mice resulted alterations microbiota. Furthermore, cocaine-mediated...