A5001461813- Fungal Biology and Applications
- Gut microbiota and health
- Microbial Natural Products and Biosynthesis
- Drug-Induced Hepatotoxicity and Protection
- Ginseng Biological Effects and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Genomics, phytochemicals, and oxidative stress
- Liver Disease and Transplantation
- Medicinal Plants and Neuroprotection
- Tryptophan and brain disorders
- Nutrition, Genetics, and Disease
- Metabolomics and Mass Spectrometry Studies
- Pomegranate: compositions and health benefits
- Medicinal Plants and Bioactive Compounds
- Food Science and Nutritional Studies
- Phytochemistry and Bioactivity Studies
- Nitrogen and Sulfur Effects on Brassica
- Phytochemistry and biological activity of medicinal plants
- Advanced biosensing and bioanalysis techniques
- Aldose Reductase and Taurine
- Tea Polyphenols and Effects
- Phytochemistry and Bioactive Compounds
- Phytochemistry and biological activities of Ficus species
Northwest A&F University
2025
Shandong University of Traditional Chinese Medicine
2024
ZheJiang Academy of Agricultural Sciences
2020-2024
State Key Laboratory of Microbial Technology
2023
Shandong University
2023
Peking University
2019-2021
Sericultural Research Institute
2018-2020
State Administration of Traditional Chinese Medicine of the People's Republic of China
2019
Nanjing Agricultural University
2017
Chinese Academy of Sciences
2014
Abstract Inflammatory bowel disease (IBD) is a significant global health concern. The gut microbiota plays an essential role in the onset and development of IBD. Sanghuangporus (SH), traditional Chinese medicinal mushroom, has excellent anti‐inflammatory effects effective at modulating microbiota. Despite these attributes, specific anticolitic SH mechanisms through which mediates its benefits remain unclear. Herein, we demonstrated that polyphenol‐rich extract from effectively alleviated...
Introduction:Cordyceps militaris, which has many potential medicinal properties, rarely been reported to alleviate type 2 diabetes mellitus (T2DM). Methods: The effects of C. militaris extracts (CE) and cordycepin (CCS) on high-fat diet streptozotocin (STZ) induced T2DM mice were analysed by gut microbiome metabolomics methods in this study. Results: results demonstrated that glucose lipid metabolism parameters, oxidative stress biomarkers inflammation cytokines down-regulated the CCS CE...
Pomegranates is abundant in polyphenols and well-known for its antioxidant activity. Punicalagin (PG) a major polyphenolic compound the pomegranate peel. In certain conditions, PG can be hydrolyzed to punicallin (PL) ellagic acid (EA), PL further EA. PG, PL, EA all play important roles activity of peels. This study was conducted compare vitro vivo anti-oxidative stress effects For test, 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·) superoxide anion ( O2·¯) scavenging capacities,...
Hyperlipidemia is a worldwide epidemic with an obvious gender disparity in incidence. Modulations on gut microbiota by traditional Chinese medicines (TCM) are emerging as potential rationale governing the profitable effects of drugs hyperlipidemia. However, it unclear how microbes regulate progression Here, we found that mulberry leaf extract (MLE) and its active component 1-deoxynojirimycin (DNJ) diminished hyperglycemia hypertriglyceridemia similar efficacy male female mice but...
Phellinus gilvus (Schwein.) Pat, a species of 'Sanghuang', has been well-documented for various medicinal uses, but the genome information and active constituents are largely unknown. Here, we sequenced whole-genome P. gilvus, identified phenylpropanoids as its key anti-cancer components, deduced their biosynthesis pathways. A 41.11-Mb sequence was assembled heatmap created with high-throughput chromosome conformation capture techniques data suggested all bins could be clearly divided into...
In a greenhouse pot experiment, dandelion (Taraxacum platypecidum Diels.) and bermudagrass (Cynodon dactylon[Linn.] Pers.), inoculated with without arbuscular mycorrhizal fungus (AMF) Rhizophagus irregularis, were grown in chromium (Cr)-amended soils (0 mg/kg, 5 10 20 mg/kg Cr[VI]) to test whether (AM) symbiosis can improve Cr tolerance different plant species. The experimental results indicated that the dry weights of both species dramatically increased by AM symbiosis. Mycorrhizal...
Mulberry leaf has potential in lipid-lowering. Here, we compared the chemical composition and lipid-lowering effects of different mulberry leaf-derived teas, investigated their underlying gut microbiome-related mechanisms. The main components tea were flavonoids, phenolic acids alkaloids, with green (0.60% polyphenols, 3.35% polysaccharides, 0.20% DNJ) containing higher levels than black (0.40% 2.95% 0.15% DNJ). Accordingly, efficacy was superior to that high-fat (HFD)-induced hyperlipidemic...
Phellinus igniarius, which is called Sanghuang in Chinese, a fungal herb widely used Traditional Chinese Medicine to treat stomachache, inflammation and tumors. Recent studies have demonstrated the antitumor, anti-diabetic, anti-inflammatory immunity-modulating activities of P. igniarius. In present study, we investigated that ameliorating effect aqueous extract igniarius fruiting body (SH) on dextran sodium sulfate (DSS)-induced colitis C57BL/6 mice. Treatment with SH (250 400 mg/kg) for 8...
Skatole, a strong fecal odor substance, is generated through microbial degradation of tryptophan in the animal hindgut. It easily accumulates adipose tissue and affects meat quality. In this study, effect mulberry leaf supplementation on skatole finishing pigs was studied. 35-day trial, 20 (barrows gilts) were fed with basal diet or 6% leaves. Growth performance (
Phellinus baumii extract (PBE) possesses considerable α-glucosidase-inhibited activity. This study investigated the hypoglycemic effect in vitro and vivo using a glucose consumption assay HepG2 cells, intragastric administration for ten weeks STZ-induced mice, intestinal flora fermentation patients with type 2 diabetes to reveal possible underlying mechanisms. PBE was prepared, including ethanol (EE) aqueous (AE). In vitro, promoted enhanced glycogen content hexokinase activity but lowered...
Abstract Sanghuangporus vaninii , called “Sanghuang,” is orally used for health care, tumor, and inflammation treatment in Asia. However, the safety of S. has not been evaluated. The major compounds analysis showed that aqueous extracts fruiting body were rich polysaccharides, nucleotides, polyphenols. Then, was given to Sprague–Dawley rats toxical test. In acute toxicity study, maximum tolerated dose 21 g/kg. 17‐week repeated experiment, all had no abnormal reaction among control group, low...
Cassiae semen are dried and ripe seeds of Cassia obtusifolia L. or tora (Fabaceae) have been made into roasted tea used as a traditional medicine in Asian countries. However, it was reported to result liver renal toxicity. The components that induce hepatotoxicity nephrotoxicity remain unknown. In the present study, we evaluate potential toxicity 26 newly isolated compounds from using quantitative structure–activity relationship (QSAR) methods co-culture hepatic cell approaches, aim...
Antibiotics are the most commonly used growth-promoting additives in pig feed especially for weaned piglets. But recent years their use has been restricted because of bacterial resistance. Phellinus, a genus medicinal fungi, is widely Asia to treat gastroenteric dysfunction, hemrrhage, and tumors. Phellinus reported improve body weight on mice with colitis. Therefore, we hypothesize that it could benefit health growth piglets, be as an alternative antibiotic. Here, effect gilvus mycelia (SH)...
<em>Sanghuangporus vaninii</em>, also called 'Sanghuang' mushroom in Chinese, has various medicinal uses, but its effects on human melanoma cells have not been reported. The present study investigated the inhibitory ability and potential anticancer mechanism of aqueous extracts <em>S. vaninii</em> (SH). results revealed that SH inhibited proliferation A375 a dose‑dependent manner, flow cytometry analysis suggested induced cell cycle arrest at S phase apoptosis. Reverse...
Sanghuangprous vaninii is a wood-inhabiting fungus, and its mycelium fruiting body show excellent medicinal values. Mulberry one of the major hosts S. , however, mechanism mulberry affecting growth has not been reported. In present study, mulberry-inhabiting strain was selected to explore effects branch extracts (MBE) on strain. Results showed that MBE could significantly promote at concentration 0.2 g/l. After 16 days liquid culture, dry weight in g/l medium higher by three times compared...