A5027160505- Gastrointestinal Bleeding Diagnosis and Treatment
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Microscopic Colitis
- Colorectal Cancer Screening and Detection
- Immunodeficiency and Autoimmune Disorders
- Mechanical Circulatory Support Devices
- Foreign Body Medical Cases
- Eosinophilic Esophagitis
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Restraint-Related Deaths
- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Liver Diseases and Immunity
- Medical Device Sterilization and Disinfection
- Biosimilars and Bioanalytical Methods
- Clinical Nutrition and Gastroenterology
- Anesthesia and Sedative Agents
- Colorectal Cancer Surgical Treatments
- Pharmaceutical studies and practices
- Autoimmune and Inflammatory Disorders
- Abdominal vascular conditions and treatments
- Traumatic Ocular and Foreign Body Injuries
Washington University in St. Louis
2015-2024
Jewish Hospital
2021
Barnes-Jewish Hospital
2012-2021
Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron , followed by whole-genome transcriptional profiling of bacteria mass spectrometry cecal glycans. We that these assembled food particles mucus, selectively induced outer-membrane polysaccharide-binding proteins glycoside hydrolases, prioritized the consumption liberated hexose sugars, revealed a capacity to turn host...
Background and aims:Vedolizumab inhibits leucocyte vascular adhesion migration into the gastrointestinal tract through α4β7 integrin blockade. This agent became available in mid-2014 for treatment of moderate to severe Crohn's disease (CD) UC (UC). The aim this study was assess patterns use, effectiveness safety vedolizumab an inflammatory bowel (IBD) clinical practice.
The pathophysiology of Crohn's-like disease the pouch (CDP) in patients with a history ulcerative colitis (UC) is unknown. We examined mucosal cells from and without CDP using single-cell analyses.
In inflammatory bowel disease, protein misfolding in the endoplasmic reticulum (ER) potentiates epithelial barrier dysfunction and impairs mucosal healing. Tauroursodeoxycholic acid (TUDCA), a naturally occurring bile acid, acts as chemical chaperone to reduce aggregation colitis severity preclinical models. We conducted an open label trial evaluating oral TUDCA therapy patients with active ulcerative (UC). Patients moderate-to-severely UC (Mayo score ≥6, endoscopic subscore ≥1) received at...
Introduction: Video Capsule Endoscopy (VCE) allows for complete visualization of the small bowel. Prior meta-analyses suggest that bowel preparation prior to VCE enhances diagnostic yield and (Rokkas AJG 2009). The aim this study was create a validated scoring system determine segmental bowel, adequacy. Methods: Three gastroenterologists with extensive experience in (>1000 VCE) prospectively reviewed 25 Given® studies. All patients received 2L Golytely® VCE. Clinical data blinded. Prokinetic...
Abstract Background Emerging evidence has demonstrated that protein misfolding in the endoplasmic reticulum (ER), i.e., ER stress, plays fundamental roles IBD development humans. Patients with active Crohn’s disease and ulcerative colitis exhibit signs of stress their ileal and/or colonic epithelium. Human genetic studies have identified primary abnormalities several genes encode proteins associated stress. We recently reported oral delivery tauroursodeoxycholic acid (TUDCA), a naturally...
Abstract Background & aim Smoking is a major risk factor for multiple gastrointestinal cancers, and adversely affects peptic ulcer disease, gastroesophageal reflux, pancreatitis Crohn’s disease. Despite key recommendations diagnosing treating tobacco use disorder in healthcare settings, the degree to which this implemented Gastroenterology (GI) clinics unknown. We aimed assess our providers’ practices, identify barriers implementing evidence-based smoking cessation treatments, address...
Chen, Chien-Huan PhD, MD; Jonnalagadda, Sreeni MDEditor(s): Baker, Kathy A. RN, ACNS-BC, CGRN, Editor