A5069684230- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
- Retinoids in leukemia and cellular processes
- HER2/EGFR in Cancer Research
- Growth Hormone and Insulin-like Growth Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related Molecular Pathways
- Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Hormonal and reproductive studies
- Genomics and Chromatin Dynamics
- Cancer Risks and Factors
- Artificial Intelligence in Healthcare
- TGF-β signaling in diseases
- Foot and Ankle Surgery
- Cardiovascular and Diving-Related Complications
- Cardiovascular Health and Risk Factors
- Genomics, phytochemicals, and oxidative stress
- Connexins and lens biology
- Thyroid Disorders and Treatments
- Hedgehog Signaling Pathway Studies
- Ovarian cancer diagnosis and treatment
All India Institute of Medical Sciences Raipur
2017-2025
National Institute on Alcohol Abuse and Alcoholism
2008-2011
Indiana University – Purdue University Indianapolis
2011
Indiana University School of Medicine
2011
University of Minnesota
2011
Richard L. Roudebush VA Medical Center
2011
Howard University
2002-2009
Institute of Cytochemistry and Molecular Pharmacology
2005-2008
Central Food Technological Research Institute
2008
Augusta University
1989-1990
Four different human tissues and breast cancer cell lines were screened to identify exon deletion variant transcripts of estrogen receptor β (ERβ) by reverse transcription‐polymerase chain reaction using the ‘splice targeted primer approach’ that amplifies each category deleted variants as a separate gene population. A total 10 mRNAs have deletions in various combination exons identified sequence analysis. They 2Δ; 2 5–6Δ; 3Δ; 4Δ; 5Δ; 5 6Δ; 6 6, 2–3Δ; 5–6Δ. In some cases, an appears be...
In individuals with diabetic hypertension, silent coronary artery disease (CAD) is common due to underlying chronic inflammation but there no biomarker monitor this high-risk group of before noticeable symptoms emerge clinically. cfDNA from dying endothelial cells triggers inflammation, leading us hypothesize that enzymes degrade cfDNA, DNase I and/or II, could serve as more sensitive biomarkers for CAD. To test this, we conducted a study 30 hypertensive patients clinical CAD (CAD-HTN-DM)...
Background: We recently reported that exposure of human cells in vitro to acetaldehyde resulted the activation Fanconi anemia–breast cancer susceptibility (FA‐BRCA) DNA damage response network. Methods: To determine whether intracellular generation from ethanol metabolism can cause and activate FA‐BRCA network, we engineered HeLa metabolize alcohol by expression dehydrogenase (ADH) 1B. Results: Incubation HeLa‐ADH1B with (20 mM) accumulation media, which was prevented co‐incubation 4‐methyl...
Importance The prevalence of polycystic ovary syndrome (PCOS) varies across the globe. Indian studies on PCOS are limited by poor design, small sizes, regional representations, and varying methods. Objectives To estimate nationwide in India, examine phenotypic spectrum, assess magnitude comorbidities associated with PCOS. Design, Setting, Participants This cross-sectional study recruited 9824 women aged 18 to 40 years from November 1, 2018, July 31, 2022, 5 zones country. A prevalidated...
Abstract We have investigated the expression of two estrogen receptor β (ERβ) isoforms, ERβ1 and ERβ5, which activate gene transcription independent or growth factors, in ERα-negative breast cancer tissues. report here, for first time, that tissues express significant levels their are not different from ERα positive tumors. However, differences exist between racial groups, African American Caucasian, patients former group higher ERβ5 but ERα. These factors could be potential molecular...
BP1 is a novel homeobox gene cloned in our laboratory. Our previous studies leukemia demonstrated that has oncogenic properties, including as modulator of cell survival. Here expression was examined breast cancer, and the relationship between clinicopathological data determined.Total RNA isolated from lines, tumors, matched normal adjacent tissue or autopsy. Reverse transcription polymerase chain reaction performed to evaluate expression. Statistical analysis accomplished with SAS.Analysis...
Abstract Purpose: It has been reported that approximately a million women are diagnosed with benign breast lesions include ductal hyperplasias per year in the United States. Recent studies followed have established about 8% to 9% of them will subsequently develop invasive cancer (IBC). However, currently, there no means identifying subclass “true precancerous tissues” who cancer. The purpose this study is investigate whether expression hyaluronoglucosaminidase 1 (HYAL1), known tumor...
The study is aimed to investigate the metabolic alterations and changes in biochemical parameters associated with extended mask.It was a prospective comparative conducted on 129 participants comprised of 37 healthy controls 92 health care workers using different kind masks like, cloth mask, surgical N95-FFR/PPE. Two samples day-1 day-10 were collected for analysis blood gas parameters, serum hypoxia-inducible factor-α (HIF-α), erythropoietin (EPO).Oxygen saturation percentage (sO2) 72.68 (P...
GPR30 is a cell surface estrogen receptor that has been shown to mediate number of non-genomic rapid effects and appear balance the signaling growth factors. In addition, progestins use for their actions. Therefore, could play critical role in hormonal regulation breast epithelial integrity. Deregulation events mediated by contribute tumorigenesis.To understand deregulation processes during carcinogenesis, we have undertaken this study investigate its expression at mRNA levels tumor tissues...
Abstract Background Metabolic dysregulation leading to diabetes is a major public health concern in India. While evidence has pointed role for genetic factors, there still limited knowledge regarding the specific variants that play part this process. Recent studies have implicated Tumor protein, p53, well-known tumor suppressor, maintaining metabolic homeostasis our body. Polymorphisms can disrupt function are thought increase susceptibility diabetic and prediabetic phenotypes like syndrome...
DNA is exposed to endogenous and environmental factors that can form stable lesions. If not repaired, these lesions lead transcription/replication blocking or mutagenic bypass. Our previous work has focused on 8,5'-cyclopurine 2'-deoxyribonucleosides, a unique class of oxidatively induced are specifically repaired by the NER pathway (see Brooks PJ [2008]: Repair 7:1168-1179). Here we used EMSA monitor ability sequence-specific transcription factors, HSF1, CREB, NF-kappaB "architectural"...
Yoga and meditation address mind body, affecting many molecular processes like metabolism, epigenetic, oxidative processes, subjective well-being. In this review, we have compiled the results of various clinical trials that looked into effect yoga-based intervention programs on gene expression changes in peripheral blood mononuclear cells (PBMCs). Most interventions aided maintenance genomic stability through telomere length showed improvement innate immunity. However, there is a lack...
The hormonal profile varies considerably with age, gender, ethnicity, diet or physiological state of an individual. Limited population-specific studies have studied the variations in parameters among apparently healthy women. We aimed to analyse biological reference interval for various reproductive-aged Indian women.Out 3877 participants that were clinically evaluated, 1441 subjects subjected laboratory investigations. All underwent a detailed clinical, biochemical and profiling. hormone...
Objectives: The fundamental prerequisite of a screening program is the accessible epidemiological data regarding disease burden and awareness disorder. This foremost study in this state to estimate congenital hypothyroidism (CH) glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency infants born or attending tertiary care hospital, pursuing skill development for technical staffs, creating parents. Study Design: A cross-sectional 21 months was conducted Department Biochemistry...
Introduction The quest to understand the pathophysiology behind deleterious effects of coronavirus disease 2019 (COVID-19) outbreak took a turn when involvement angiotensin converting enzyme (ACE) receptors in different organs, especially lungs, could explain all clinical manifestations and adverse events patients. I/D polymorphism ACE gene, having been attributed various studies, was also seen have an effect this pandemic. Present study aimed analyze mutation COVID-19 patients their healthy...
In the current study we tested if highest incidence of benign as well cancer growths in breast tissue is due to constitutive molecular composition this tissue. To delineate basis, compared expression nine functional gene modules (total 578 genes) that regulate major positive growth and negative inhibitory signals normal with two other reproductive tissues, ovary uterus. We present data demonstrate tissues constitutively have very highly elevated levels several promoting molecules diminished...
The most successful treatment for cancer involves identifying druggable, biological markers targeted therapy. In the clinical setting, surgical removal of tumors is only procedure such targetable molecules. Shed from tumor cells, these are also present in circulating blood, albeit very negligible amounts. Liquid biopsy a performed on blood sample to look cells or pieces nucleic acid tumor. shows promise revolutionizing personalized treatments. Here we briefly review technique,...
<sec> <title>BACKGROUND</title> Meditation is often defined as thinking continuously about one object of thought. We get stuck on this definition, however, and lose the real purpose meditation. must reveal true nature that upon which we are meditating. Such revelation comes not a thought, but feeling. Therefore, meditation process in shift from to It journey complexity mind simplicity heart. for reason most methods involve heart1 </sec> <title>OBJECTIVE</title> To project importance...
AbstractWe developed a monoclonal antibody against HPLC purified rat lens γL crystallins. This was specific to both the polypeptides (19,000 and 21,000 daltons) which constituted γ1 peak. Least reactivity shown γH (24,000b daltons). used as probe detect presence of quantitate crystallins in soluble, insoluble urea-insoluble fractions during diabetes. Utilizing direct binding immunoassay (ELISA) we calculated absolute quantities γl present these fractions. Our results show, normal animals...