A5082910957- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Reproductive Biology and Fertility
- Chronic Myeloid Leukemia Treatments
- Retinoids in leukemia and cellular processes
- Phytoestrogen effects and research
- CAR-T cell therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ovarian function and disorders
- Berberine and alkaloids research
- Cancer-related molecular mechanisms research
- Plant nutrient uptake and metabolism
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- MicroRNA in disease regulation
- CNS Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
Jinzhou Medical University
2013-2025
Anhui University of Science and Technology
2025
Anhui Science and Technology University
2025
Zhengzhou University
2014-2024
Henan Cancer Hospital
2014-2023
First Affiliated Hospital of Jinan University
2022
Tsinghua University
2022
Sichuan Normal University
2021
Nanjing Agricultural University
2021
Northeast Forestry University
2013
Premature ovarian failure (POF) is a long-term adverse effect of chemotherapy treatment. However, current available treatment regimens are not optimal. Emerging evidence suggests that bone marrow-derived mesenchymal stem cells (BMSCs) could restore the structure and function injured tissues, but homing restorative effects BMSCs on ovaries still clear. In this study, we found granulosa cell (GC) apoptosis induced by cisplatin was reduced when were migrated to (GCs) in vitro....
Background: The expressions of leptin and its receptor (ObR) have been observed in human endometrial cancer (EC) cells, can promote the proliferation EC cells. However, correlation between ObR cl
Polycystic ovary syndrome (PCOS) significantly affects women's health and well-being. To explore the pharmacological basis of Erxian decoction (EXD) action in PCOS therapy, a network interaction analysis was conducted at molecular level.The active elements EXD were identified according to oral bioavailability drug-likeness filters from three databases: traditional Chinese medicine system pharmacology platform, TCM@taiwan TCMID, their potential targets also identified. Genes associated with...
Based on the research methods of network pharmacology, this study analyzed improvement effect berberine (BBR) premature ovarian failure (POF) and its molecular mechanism. Carry out GO KEGG enrichment analysis by R language to obtain potential targets pathways BBR in POF. Use SD rats granulosa cells (GCs) for experimental verification. ELISA was used measure content related hormones serum, CCK-8 cell viability, western blot target protein ovaries GCs, q-RT-PCR detect expression genes GCs....
Oral immunization can elicit an effective immune response and tolerance to specific antigens. When compared with the traditional injection route, delivering antigens via gastrointestinal mucosa offers superior effects compliance, as well simplicity convenience, making it a more optimal route for immunization. At present, various oral vaccine delivery systems exist. Certain modified bacteria, such <em>Salmonella</em>, <em>Escherichia</em> <em>coli</em> particularly <em>Lactobacillus</em>, are...
This study aimed to propose a novel deep-learning method for automatic sleep apneic event detection and thus estimate the apnea hypopnea index (AHI) identify obstructive (OSA) in an event-by-event manner solely based on sounds obtained by noncontact audio recorder.We conducted cross-sectional of participants with habitual snoring or heavy breathing during train test deep convolutional neural network named OSAnet OSA sounds. Polysomnography (PSG) was conducted, were recorded simultaneously...
Group B streptococcal (GBS) is a Gram-positive bacterium that commonly found in the gastrointestinal tract and urogenital tract. GBS infestation during pregnancy significant contributor to maternal neonatal morbidity mortality globally. This article aims discuss infectious diseases caused by field of obstetrics gynecology, as well challenges associated with detection, treatment, prevention GBS.
Endometrial Cancer is the most common female genital tract malignancy, its pathogenesis complex, not yet fully described. To identify key genes of we downloaded gene chip GSE17025 from Gene Expression Omnibus database. Differentially expressed (DEGs) were identified through GEO2R analysis tool. Functional and pathway enrichment performed for DEGs using DAVID The network protein–protein-interaction (PPI) was established by STRING website visualized Cytoscape. Then, functional DEGS A total...
Background: Ovarian cancer (OC) is the most prevalent gynecologic malignancy, with high mortality rates. However, its pathogenesis remains unclear. The current study aimed to explore potential biomarkers and suppressor genes for diagnosing treating OC. Methods: Biochemical bioinformatics approaches were used detect differentially expressed (DEGs) in ovarian tissues via integration analysis. Kaplan-Meier plot analysis was performed assess progression-free survival overall according DEGs....
BACKGROUND:Currently available antithrombotic prophylaxis is not perfectly reliable in elderly patients. The aim of this retrospective study was to evaluate the efficacy and safety Compound Danshen Tablet (CDT) preventing thromboembolism multiple myeloma (MM) patients treated with thalidomide-based regimens. MATERIAL AND METHODS:MM regimens were retrospectively reviewed between January 2008 March 2015. Patients categorized into 3 cohorts based on thromboembolic used: CDT, Warfarin Tablet, no...
T cell immune dysfunction is a prominent characteristic of chronic lymphocytic leukemia (CLL) and the main cause failure for immunotherapy multi-drug resistance. There remains lack specific biomarkers evaluating status with outcome CLL patients. factor 1 (TCF1, encoded by TCF7 gene) can be used as critical determinant successful anti-tumor prognostic indicator in some solid tumors; however, effects TCF1 remain unclear. Here, we first analyzed biological processes functions co-expressing...
Objective: To explore the availability and safety of fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell (allo-HSCT) . Methods: Four acute leukemia suffered from allo-HSCT. One them was intestinal infection, others were graft versus host disease. or two doses microbiota, 3.4-6.0 U one dose, infused via nasal-jejunal tube. The curative effect side effects reviewed. Results: Three cases achieved complete remission while 1 stable...
To analyze the short-term efficacy, overall survival (OS), and safety in newly diagnosed extranodal NK/T-cell lymphoma (ENKTL) patients with L-asparaginase based regimens or CHOP regimen combination radiotherapy as first-line treatment.Of total 181 by imaging pathology, 69 received 112 regimens. All radical radiotherapy(RT)after 6 cycles of chemotherapy.The response rates L-asparaginase-based group were 90.2% 72.5%, respectively (P=0.002). The 1, 2, 5-year OS progression-free (PFS) 96.0%,...
The chromosomal translocation t(7;11)(p15;p15) and the resulting nucleoporin 98-homeobox A9 (NUP98-HOXA9) gene fusion is rare but recurrent genetic abnormity in acute myeloid leukemia (AML). present study describes a case of AML plus maturation (‑M2) with multilineage dyspoiesis 30‑year‑old male whom 46,XY,t(7;11)(p15;p15) karyotype was detected through chromosome analysis. Subsequent molecular sequencing analysis demonstrated NUP98‑HOXA9 type I between NUP98 exon 12 HOXA9 1b, mutations...