A5016556146- Sepsis Diagnosis and Treatment
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Artificial Intelligence in Healthcare
- Lipoproteins and Cardiovascular Health
- Pregnancy and preeclampsia studies
- Parathyroid Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Diversity and Career in Medicine
- Health Systems, Economic Evaluations, Quality of Life
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Computational Drug Discovery Methods
- Healthcare Technology and Patient Monitoring
- Grief, Bereavement, and Mental Health
- Attachment and Relationship Dynamics
- COVID-19 Impact on Reproduction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmaceutical Economics and Policy
- Genetic Associations and Epidemiology
- Long-Term Effects of COVID-19
- Migration, Health and Trauma
- Heavy Metal Exposure and Toxicity
- Genomics and Chromatin Dynamics
- COVID-19 and healthcare impacts
- Kidney Stones and Urolithiasis Treatments
Stanford University
2022-2024
University of Maryland, College Park
2016-2024
Stanford Health Care
2022-2023
Cardiovascular Institute of the South
2023
Northwestern University
2020-2022
Background Statins are guideline-recommended medications that reduce cardiovascular events in patients with diabetes. Yet, statin use is concerningly low this high-risk population. Identifying reasons for nonuse, which typically described unstructured electronic health record data, can inform targeted system interventions to improve use. We aimed leverage a deep learning approach identify nonuse Methods and Results Adults diabetes no prescriptions were identified from multiethnic, multisite...
Compelling evidence suggests that defective DNA damage response (DDR) plays a key role in the premature aging phenotypes Hutchinson-Gilford progeria syndrome (HGPS). Studies document widespread alterations histone modifications HGPS cells, especially, global loss of H3 trimethylated on lysine 9 (H3K9me3). In this study, we explore potential connection(s) between H3K9me3 and impaired DDR HGPS. When cells are exposed to DNA-damaging agent Doxorubicin (Dox), double strand breaks (DSBs)...
Statins are the cornerstone of treatment patients with atherosclerotic cardiovascular disease (ASCVD). Despite this, multiple studies have shown that women ASCVD less likely to be prescribed statins than men. The objective this study was use Natural Language Processing (NLP) elucidate factors contributing disparity. Our cohort included adult two or more encounters between 2014 and 2021 an diagnosis within a multisite electronic health record (EHR) in Northern California. After reviewing...
Background Guidelines recommend catheter ablation of atrial fibrillation (AFCA) as an option for rhythm control. Studies have shown that Black patients are less likely to undergo AFCA compared with White patients. We investigated whether differences in referral patterns play a role this observed disparity. Methods and Results Using integrated repository from the electronic medical record at Northwestern Medicine, we conducted retrospective cohort study outpatients newly diagnosed...
There are established sex-specific differences in heart failure with reduced ejection fraction (HFrEF) outcomes. Randomized clinical trials (RCTs) based on cardiovascular outcome benefits, typically either mortality or hospitalization for (HHF), influence current guidelines therapy. We evaluate the representation of women HFrEF RCTs that observed all-cause HHF. queried Cumulative Index to Nursing and Allied Health Literature, Excerpta Medica dataBASE, Medical Literature Analysis Retrieval...
This research provides a conceptual replication and theoretical extension of the mutual cyclical growth model. model proposes that dependence promotes relationship commitment, which pro-relationship behavior, which—when detected by partners—promotes partners’ trust, willingness to depend on relationship. Prior supports these links month-to-month basis, but romantic thoughts, feelings, behaviors may change day-to-day basis. The present sought replicate daily level, extend with an important...
BACKGROUND: Disparities in guideline-based quality measures likely contribute to differences heart failure (HF) outcomes. We evaluated between- and within-hospital the of care across sex, race, ethnicity, insurance for patients hospitalized HF. METHODS: This retrospective analysis included HF 596 hospitals Get With Guidelines-HF registry between 2016 2021. performance 7 stratified by patient insurance. with without adjustment treating hospital. also measured variation hospital-specific...
The death of a child is felt by extended family, friends, and community members. Most bereavement care research focuses on programs for parents. Little known about the efficacy support other grieving individuals. We conducted scoping review literature describing siblings, family (other than parents), members after pediatric death. found only four reports this population. All articles described benefits intervention studied. Overall, more rigorous larger-scale studies are needed.
This study aimed to compare the performance of a pediatric decision support algorithm detect severe sepsis between high-risk and adult patients in emergency department (PED).This is retrospective cohort presenting from March 2017 February 2018 tertiary care PED. Patients were identified as high risk for based on priori defined criteria considered if 18 years or older. The 2-step consists (1) an electronic health record best-practice alert (BPA) with age-adjusted vital sign ranges, (2)...
Although cardiovascular disease (CVD) is the leading cause of death in women, risk factors remain underrecognized and undertreated. Hyperlipidemia one modifiable for CVD. Statins are mainstay lipid lowering therapy (LLT), with additional agents such as ezetimibe proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors additive or alternative therapies. Clinical trials have demonstrated that these LLTs equally efficacious reduction women they men. data on statin teratogenicity...
Background: There are established sex-specific differences in heart failure with reduced ejection fraction (HFrEF) outcomes. Randomized clinical trials (RCTs) based on cardiovascular outcome benefits, typically either mortality or hospitalization for (HHF), and influence current guidelines therapy. Objectives: To evaluate the representation of women HFrEF RCTs that observed all-cause HHF. Methods: We queried Excerpta Medica dataBASE, Medical Literature Analysis Retrieval System Online,...
Introduction: Left ventricular systolic dysfunction (LVSD) has been observed in COVID-19 and is thought to be multifactorial. The epidemiology of stress cardiomyopathy these patients not studied. Methods: Transthoracic echocardiograms (TTE) were evaluated consecutive admitted a large tertiary care center Chicago, Illinois. Subjects with new LVEF ≤50% prior normal or unknown baseline compared those >50% previously known LVSD. InterTAK scores calculated for all LVSD, cutoff 50 was used...
Introduction: Statins are life-saving medications for patients with atherosclerotic cardiovascular disease (ASCVD), but women ASCVD persistently less likely to be prescribed statins than men. This study aims use Natural Language Processing (NLP) further elucidate patient and provider factors contributing this disparity. Methods: The cohort included >2 encounters between 2014 2021 within a multisite electronic health record (EHR) in Northern California. Data from random sample of our (N =...
Introduction: Statins are guideline-recommended and potentially life-saving for individuals with diabetes. Yet, statin use is concerningly low in this group. Identifying reasons nonuse can inform targeted interventions. We hypothesize that clinical reasoning around may be buried unstructured, narrative portions of the electronic health record (EHR). aimed to identify patients diabetes from unstructured EHRs using deep learning. Methods: Adults diagnosed 2014 2020 no prescriptions were...
Introduction: The goal of cardiovascular training programs is to increase recruitment women and underrepresented in medicine (UIM) trainees. Due the COVID-19 pandemic, virtual interviewing replaced in-person for cardiology fellowship applications United States. However, there little data on influence these changes candidate diversity. Methods: In a single-center retrospective study, we identified demographic profiles trainees who interviewed Stanford University Cardiovascular Fellowship...
Background: Sepsis is a leading cause of morbidity and mortality among children, with early recognition treatment impacting long-term health outcomes. While studies show screening interventions embedded in electronic records can improve outcomes, evaluating such challenged by the lack universal reference standard pediatric sepsis. Objective: Evaluate test characteristics an sepsis algorithm (Figure 1) implemented emergency department (PED) using two standards for defining Design/Methods:...