A5101413783- Mechanical stress and fatigue analysis
- Railway Engineering and Dynamics
- Fatigue and fracture mechanics
- Gear and Bearing Dynamics Analysis
- Nuclear Structure and Function
- Genetics, Aging, and Longevity in Model Organisms
- Biological and pharmacological studies of plants
- Skin Protection and Aging
- Natural Fiber Reinforced Composites
- Ion Channels and Receptors
- Advanced machining processes and optimization
- Structural Health Monitoring Techniques
- Polymer Nanocomposites and Properties
- Extracellular vesicles in disease
- DNA Repair Mechanisms
- Insect and Pesticide Research
- Metallic Glasses and Amorphous Alloys
- Vibration and Dynamic Analysis
- Phase-change materials and chalcogenides
- Calcium signaling and nucleotide metabolism
- Advanced Measurement and Metrology Techniques
- Metal Alloys Wear and Properties
- Neurological Disease Mechanisms and Treatments
- Protein Interaction Studies and Fluorescence Analysis
- Cell death mechanisms and regulation
Zhejiang University
2019-2024
China Academy of Railway Sciences
2017-2024
Chang'an University
2023
Northwestern Polytechnical University
2023
University of Maryland, College Park
2016-2022
Shandong University of Traditional Chinese Medicine
2022
Ministry of Agriculture and Rural Affairs
2020
Qingdao University of Science and Technology
2014-2019
Oxidative stress is the major cause of skin aging that includes wrinkles, pigmentation, and weakened wound healing ability. Application antioxidants in care well accepted as an effective approach to delay process. Methylene blue (MB), a traditional mitochondrial-targeting antioxidant, showed potent ROS scavenging efficacy cultured human fibroblasts derived from healthy donors patients with progeria, genetic premature disease. In comparison other widely used general antioxidants, we found MB...
Abstract This paper proposes a novel method based on continuum damage mechanics (CDM) and machine learning (ML) models to evaluate the vibration fatigue behavior of W1‐type railway fastener clips subjected high‐frequency vibration. Firstly, static tests are conducted 60Si2Mn spring steel acquire elastic modulus, tensile strength, P‐S‐N curves. Subsequently, CDM model is established, numerical simulations performed under various working conditions obtain characteristics clips. Finally, ML...
Compelling evidence suggests that defective DNA damage response (DDR) plays a key role in the premature aging phenotypes Hutchinson-Gilford progeria syndrome (HGPS). Studies document widespread alterations histone modifications HGPS cells, especially, global loss of H3 trimethylated on lysine 9 (H3K9me3). In this study, we explore potential connection(s) between H3K9me3 and impaired DDR HGPS. When cells are exposed to DNA-damaging agent Doxorubicin (Dox), double strand breaks (DSBs)...
Abstract Senescence of vascular endothelial cells is the major risk dysfunction and disease among elderly people. Parishin, which a phenolic glucoside derived from Gastrodia elata , significantly prolonged yeast lifespan. However, action parishin in ageing remains poorly understood. Here, we treated human coronary artery (HCAEC) naturally aged mice by parishin. Parishin alleviated HCAEC senescence general age‐related features tissue mice. Network pharmacology approach was applied to...
Astilbin is a dihydroflavonol glycoside identified in many natural plants and functional food with promising biological activities which used as an antioxidant the pharmaceutical fields. This work investigated interaction between astilbin human serum albumin (HSA) their effects on activity of by multi-spectroscopic molecular modeling studies. The experimental results show that quenches fluorescence emission HSA through static quenching mechanism. prefer to bind at Site Ⅰ position, mainly...
To study the static‒dynamic characteristics and vibration fatigue failure mechanism of railway fastening clips, modal clip in free installed states are obtained via field experiments, a refined finite element model system is established verified. Then, analysis frequency response carried out based on numerical model, effects excitation with varied amplitudes frequencies life distribution damage peril points (CFDPPs) investigated. Eventually, method dividing sensitive range (CVFSFR) proposed....
Cardiac aging progressively decreases physiological function and drives chronic/degenerative aging-related heart diseases. Therefore, it is crucial to postpone the process of create products that combat aging.The objective this study examine effects parishin, a phenolic glucoside isolated from traditional Chinese medicine Gastrodia elata, on anti-aging its underlying mechanism. To assess senescent biomarkers, cardiac function, weight/body weight ratio, transcriptomic changes,...
It is usually difficult to obtain the modal characteristics of rail fastening clip analytically owing its complex spatial structure and operating environments. Therefore, experimental testing frequently adopted identify clips. This study takes SKL 15 Vossloh 300-1 system as research object analyse following three aspects in great detail: (1) Locations measurement points are reasonably designed capture all modes frequency range 0–1000 Hz. (2) The appropriate sensors selected for different...
Abstract The potential risks of Bt rice on non-target arthropods (NTAs) should be evaluated and defined before commercial production. Recently, effects NTAs under abiotic biotic stress conditions attracted much attention. Here we reported the T1C-19 (Cry1C rice) herbivore, Nilaparvata lugens (rice brown planthopper, BPH) with or without RDV ( dwarf virus ) infection conditions. BPH showed no feeding oviposition preference between its non- parental Minghui 63 (MH63), as well RDV-infected...
hTERT gene therapies hold significant promise for treating age-related diseases. However, further research is required to address the challenges of delivery and ethical considerations. We hypothesized that exosomes derived from hTERT-immortalized cells could function similarly by maintaining telomere length attenuating cellular senescence biomarkers. In this study, we overexpressed in Human Foreskin Fibroblast-1 (HFF cells) produce HFF (hT-HFF cells). then used these hT-HFF treat human...
Parishin, a natural compound, has demonstrated significant potential in mitigating age-related phenotypes and improving outcomes age-associated diseases. Given that aging is major risk factor for numerous chronic conditions, including pulmonary fibrosis, we investigated parishin's effects on cellular senescence lung health. In our study, treated mouse epithelial cells with parishin observed reduction markers alongside an upregulation of sirtuin 1 (SIRT1). Building these
Fluid-solid coupling theory is introduced into tripod sliding universal joint design. The geometric models of the and lubricant film are established respectively meshed. analyses joints in unidirectional bidirectional scenarios performed to investigate sleeve as well pin under various differential pressures frequencies. In condition coupling, deformation stress increase gradually with pressure frequency. Under frequencies, greater than those coupling. fluid-solid combined for first time this...
Abstract Hutchinson-Gilford progeria syndrome (HGPS) is a detrimental premature aging disease caused by point mutation in the human LMNA gene. This results abnormal accumulation of truncated pre-lamin A protein called progerin. Among drastically accelerated signs HGPS patients, severe skin phenotypes such as alopecia and sclerotic skins always develop with progression. Here, we study molecular mechanisms focusing on early development differentiating patient-derived induced pluripotent stem...
Hutchinson–Gilford progeria syndrome (HGPS) is a detrimental premature aging disease caused by point mutation in the human LMNA gene. This results abnormal accumulation of truncated pre-lamin A protein called progerin. Among drastically accelerated signs HGPS patients, severe skin phenotypes such as alopecia and sclerotic skins always develop with progression. Here, we studied molecular mechanisms focusing on early development differentiating patient-derived induced pluripotent stem cells...
In this article, a fluid–solid coupling analysis of tripod sliding universal and lubricating oil film was conducted by taking into consideration cavitation thermal effects. The the sleeve slip pin with lubricant under different pressure differences frequencies investigated. Moreover, study results were compared ideal condition negligible When considering these effects, deformation stress values gradually increase as difference frequency increase. are reduced relative to calculation in...
Abstract This paper introduces an approximate grinding method (AGM) and tooth flank deviation correction strategies for helical face gears (HFGs) generated by worm, addressing the issue of singularities on worm thread surface that hinders HFGs properly. Firstly, flanks gear are derived, determined. Then, based generation theory HFGs, AGM is proposed to solve challenge with a large helix angle. Next, HFG investigated, meanwhile, contact pattern transmission error analysis conducted. In...
In railway systems, layered structures could be induced in wheel–rail contact interfaces due to several causes, such as head hardening, work plastic deformation, and mechanical or thermal excursion-induced phase transformation. This study proposes an explicit finite element (FE) method for investigating elastic layer effects rolling contact. The proposed is first validated by comparing its solution with that of Kalker’s boundary (BEM) when the not present, a focus on tractive To investigate...