A5044171568- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Inflammatory Myopathies and Dermatomyositis
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Systemic Sclerosis and Related Diseases
- Bone and Joint Diseases
- Meta-analysis and systematic reviews
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Cancer Cells and Metastasis
- Lipid metabolism and disorders
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Ferroptosis and cancer prognosis
- Liver physiology and pathology
- Biochemical effects in animals
- Pulmonary Hypertension Research and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Migraine and Headache Studies
- Coronary Interventions and Diagnostics
- Immune cells in cancer
Affiliated Hospital of Youjiang Medical University for Nationalities
2016-2024
Gansu Provincial Hospital
2021-2022
Hubei University of Medicine
2013-2022
Dongfeng General Hospital
2022
China National Pharmaceutical Group Corporation (China)
2022
Ionis Pharmaceuticals (United States)
2022
Southwest Medical University
2022
Taizhou Municipal Hospital
2020
Dezhou University
2019
Zhengzhou People's Hospital
2017
Autophagy has been shown to maintain neural system homeostasis during stroke. However, the molecular mechanisms underlying neuronal autophagy in ischemic stroke remain poorly understood. This study aims investigate regulatory of pathway consisting MEG3 (maternally expressed gene 3), microRNA-378 (miR-378), and GRB2 (growth factor receptor-bound protein 2) neurological functional impairment A mouse model middle cerebral artery occluded–induced an vitro oxygen-glucose deprivation–induced...
Abstract Fatty liver disease (FLD) is a growing health issue with burdening unmet clinical needs. FLD has genetic component but, despite the common variants already identified, there still missing heritability component. Using candidate gene approach, we identify locus (rs71519934) at Pleckstrin and Sec7 domain-containing 3 ( PSD3 ) resulting in leucine to threonine substitution position 186 of protein (L186T) that reduces susceptibility entire spectrum individuals risk. downregulation by...
Acute myocardial infarction (AMI), as the first manifestation of ischemic heart disease, is most common cause death in developed countries. A recent study showed that metastasis associated lung adenocarcinoma transcript 1 (MALAT1), a prognostic marker for cancer metastasis, could promote ischemia‑reperfusion injury by regulating levels microRNA (miR)‑145. In order to elucidate biological function MALAT1 pathogenesis AMI and explore mechanisms underlying its action, an rat model was...
Impaired wound healing is a common complication of diabetes. In diabetic wounds, macrophages present dysfunctional efferocytosis and abnormal phenotypes, which could result in excessive neutrophil accumulation prolonged inflammation, thereby eventually hindering repair. ANXA1 N-terminal peptide Ac2-26 exhibits high potential mitigating inflammation improving repair; however, its efficacy repair remains unclear. this study, cutaneous excisional model was built genetically mice. or vehicle...
Polymyositis (PM) is an autoimmune disease characterized by chronic inflammation in skeletal muscle. Mean platelet volume (MPV), a marker the assessment of systemic inflammation, easily measured automatic blood count equipment. However, to our knowledge, there are no data literature with respect MPV levels PM patients. Therefore, this study we aimed investigate patients PM. This included 92 newly diagnosed and 100 healthy individuals. were found be significantly lower compared controls...
Abstract Background Familial hypercholesterolemia (FH) is the most commonly inherited metabolic disease and has an autosomal dominant mode of inheritance. Patients with FH usually present high levels low-density lipoprotein-cholesterol, xanthomas early coronary artery disease. Children are subject to developing enhanced atherosclerosis, leading increased risk events. We report here 8-year-old patient acute syndrome (ACS) who was diagnosed homozygous (HoFH) due mutations in lipoprotein...
Aim. To investigate the expressions of glutathione peroxidase 1 (GPX1) and caudal-related homeodomain transcription factor (CDX2) in GAC their correlation with clinicopathological features tumor cell proliferation. Methods. The GPX1, CDX2, Ki67 were immunohistochemically evaluated 172 specimens. association GPX1 CDX2 patient's positive rate was analyzed statistically. Results. In cases GAC, expression weaker than that adjacent normal mucosa, higher mucosa. High strong-expression associated...
Using a rat comb thermal damage model, we investigated the effects of topically administered recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on peroxisome proliferator-activated receptor PPARβ expression. We created bilateral scald models backs fifty Sprague-Dawley rats. The left sides served as experimental group and right control group. received applied rhGM-CSF hydrogel did not. survival situations stasis zones were compared between groups 1st, 3rd, 7th, 14th...
<title>Abstract</title> Purpose Endometriosis (EMT) affects millions of women worldwide and is closely associated with the body's response to oxidative stress. The role stress markers in diagnosis treatment endometriosis a potentially fruitful avenue research. Methods In this study, we employed machine learning approach model screen key biomarkers, integrating five independent datasets from Omnibus (GEO) database construct comprehensive training set. identification genes was achieved through...
Right ventricle/ventricular (RV) failure induced by sustained pressure overload is a major contributor to morbidity and mortality in several cardiopulmonary disorders. Reliable reproducible animal models of RV are crucial for investigating disease mechanisms the effects potential therapeutic strategies. In present study, order establish rat model acute failure, hemodynamic characteristics carotid artery rats with varying degrees pulmonary banding (PAB) were analyzed. For this purpose,...
Abstract Background Circulating exosomal microRNAs are reflective of the characteristics tumor, valuable biomarkers in different types tumors, and play important roles tumor progression metastasis. The purpose this study was to investigate circulating miRNA-21 miRNA-210 as novel for patients with pancreatic cancer (PC).Methods Serum were extracted from serum PC chronic pancreatitis (CP) using an RNA Isolation kit. To identify exosomes serum, we used transmission electron micrographs...
Abstract Background Borax, a boron compound, which is becoming widely recognized for its biological effects, including antioxidant activity, cytotoxicity, and potential therapeutic benefits. However, the specific molecular mechanisms underlying borax-induced anti-tumor effect still remain to be further elucidated. MicroRNAs (miRNAs) may play key roles in cellular processes tumor progression, cell apoptosis cytotoxicity. Thus, this study aimed investigate, whether miRNAs were involved...
Objective: Three modeling methods were used to establish a mouse primary liver cancer model, and compared them find more optimal method. Methods: Forty 15-day-old C3H/HeN male mice randomly divided into groups I-IV, 10 in each group. Group Ⅰ not treated; Ⅱ intraperitoneally injected with 25 mg/kg diethylnitrosamine (DEN) once; Ⅲ 100 DEN Ⅳ once followed by another intraperitoneal injection of at 42 days age. The mortality group was analyzed. At the 18th week modeling, blood collected from...