A5103142447- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Orthopedic Infections and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Orthopaedic implants and arthroplasty
- Surgical site infection prevention
- Management of metastatic bone disease
- Testicular diseases and treatments
- Bone health and treatments
- Bone fractures and treatments
- RNA modifications and cancer
- Childhood Cancer Survivors' Quality of Life
- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- Parvovirus B19 Infection Studies
- Surgical Sutures and Adhesives
- Neuroblastoma Research and Treatments
- Ubiquitin and proteasome pathways
- Clusterin in disease pathology
- Inflammatory Biomarkers in Disease Prognosis
- Ethics and Legal Issues in Pediatric Healthcare
- Cardiac tumors and thrombi
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Surgery and Rehabilitation
- Shoulder and Clavicle Injuries
Cairo University
2008-2025
Children Cancer Hospital
2016-2025
American University in Cairo
2023
Kantonsspital Graubünden
2014
Cairo University hospitals
2009
Istituto Ortopedico Rizzoli
2005
We reviewed 124 patients with a conventional pelvic chondrosarcoma who had been treated over period of 20 years. recorded the type tumour (central or peripheral), operation (limb salvage surgery hemipelvectomy), grade tumour, local recurrence and/or metastases, in order to identify factors which might influence survival. More satisfactory surgical margins were achieved for central tumours those by hemipelvectomy. However, 1 tumours, whatever course, did not develop metastases cause death,...
Limb-salvage surgery for malignant bone tumors can be associated with considerable perioperative blood loss. The aim of this randomized controlled trial was to assess the safety and efficacy intraoperative infusion tranexamic acid (TXA) in children adolescents undergoing limb-salvage surgery. All participants were <18 years age at time diagnosed a tumor femur that treated resection reconstruction megaprosthesis. Exclusion criteria included anatomic locations other than femur, vascularized...
Osteosarcoma and Ewing sarcoma are more common diagnoses in preadolescent adolescent children compared with the adult population. A greater percentage of patients treated limb salvage reconstruction using modular tumor endoprostheses. Implant-to-bone fixation can be cemented or cementless. Cementless endoprostheses rely on biologic osteointegration for implant stability, chemotherapy during childhood adolescence disturb bone turnover rate reduce mineral density, which turn may predispose...
Background Most reports on skeletal reconstruction using vascularized fibular free flap include patients with varying age groups and anatomic locations. This study has limited the inclusion criteria to pediatric adolescent diagnosed bone sarcoma of femoral shaft. Methods Forty-one patients, a malignant tumor shaft (21 Ewing's sarcomas 20 osteosarcomas), were locally treated by joint sparing wide resection flap. All clinical radiographic data reviewed for graft healing hypertrophy as well...
Skeletal involvement in children with Langerhans cell histiocytosis (LCH) is a common feature of the disease. Several options for treatment these skeletal lesions have been reported. We describe our experience LCH this retrospective case series study, entailing anatomic distribution, pattern healing, deformities, and functional outcome LCH.A analysis was conducted patients diagnosed having period between 2007 2015. Out total 229 cases, 191 (83.4%) had involvement. Bone healing divided into...
The aim of the study was to assess functional and oncological outcomes patients with distal femoral osteosarcoma managed by limb salvage using modular endoprosthesis as well related complications.A total 82 were included in our study. Functional outcome assessed MSTS score knee range motion. Oncological regarding local recurrence, chest metastasis, patient survivorship. Complications classified according Henderson et al. RESULTS: mean 26.21 (87.4%) (range 8-30 points) 70.7% having more than...
Introduction and aim . Management of complicated wounds after tumor extipiration pelvic proximal lower limb musculoskeletal sarcoma represents an essential component in the outcome these patients. The authors present modified vertical rectus abdominis musculocutaneous (VRAM) flap techniques to reconstruct extensive defects debridment wounds. Material Methods Over a period 4 years (2002–2005), 5 men 2 women were managed. Median age was 21 (range 15–49). patients managed for trunk, groin,...
Abstract Background As survival rates for children with acute lymphoblastic leukemia (ALL) improve, awareness of treatment complications becomes important. Osteonecrosis (ON) is a serious disabling complication in treated ALL patients. The aim the study was to define frequency ON identified by magnetic resonance imaging (MRI) and risk factors ON. Patients methods evaluated retrospectively 858 patients who were diagnosed at Children's Cancer Hospital Egypt from January 2009 December 2012. St...
Osteosarcoma is a primary malignant bone tumor affecting adolescents and young adults. This study aimed to identify proteomic signatures that distinguish between different osteosarcoma subtypes, providing insights into their molecular heterogeneity potential implications for personalized treatment approaches. Using advanced techniques, we analyzed FFPE samples from cohort of pediatric patients representing four various subtypes. Differential expression analysis revealed significant signature...
Background: Ewing sarcoma of the scapula is uncommon. Restoration shoulder function after total scapulectomy challenging. Extracorporeal irradiation and reimplantation a well-known method biological reconstruction in orthopaedic oncology; yet very few reports literature describe its specific use tumors scapula. Patients Methods: Ten patients with diagnosis were surgically treated by extracorporeal The mean age at presentation was 10 years (3 to 15 y). Six male individuals 4 female...
Histologic response to neoadjuvant chemotherapy is an essential prognostic criterion in osteosarcoma. Non-invasive assessment of the effect influences timing and method definitive surgery. This study evaluated use Dynamic Contrast Enhanced-MRI (DCE-MRI) preoperative estimation residual viable tumor present Osteosarcoma following chemotherapy. We conducted a prospective from July 2011 till April 2013 on 50 pediatric patients with mean age 12.8 years diagnosed as Highgrade osteosarcoma long...
Abstract Purpose Our study pursued cross-cultural adaptation, and validation of the pediatric Toronto Extremity Salvage Score (pTESS) (TESS) to assess functional outcome for Egyptian children adult survivors childhood bone cancer. Mental domains were added allow evaluation health-related quality life (HRQOL) Methods The internal consistency test-retest reliability studied forms assessed. For convergent validity, correlations between scores generic Pediatric Quality Life Inventory (PEDSQL...
Abstract Background Validated self-reporting tools are required to evaluate the functional outcome and health-related quality of life (HRQOL) for those who had extremity bone sarcomas in their childhood or adolescence. Our study pursued cross-cultural adaptation validation pediatric Toronto Extremity Salvage Score (pTESS) (TESS) assess Egyptian children adult survivors following surgeries sarcomas. In modified versions pTESS TESS, mental domains were added allow evaluation HRQOL using a...
Abstract Background In patients who have osteosarcoma of the distal femur, there is concern that when dissecting popliteal vessels from posterior soft tissue extent tumor, a less-than-wide margin resection may be achieved depending on mass. Surgeons little information to guide them deciding whether in patient whom are direct contact with mass will result an increased likelihood local recurrence compared not tumor Questions/purposes (1) Is adherent artery and vein away femoral by stripping...