A5035649315- CRISPR and Genetic Engineering
- Wheat and Barley Genetics and Pathology
- Plant Molecular Biology Research
- Genetic Mapping and Diversity in Plants and Animals
- MicroRNA in disease regulation
- RNA modifications and cancer
- Genetics and Plant Breeding
- Plant Stress Responses and Tolerance
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Plant nutrient uptake and metabolism
- Soil Mechanics and Vehicle Dynamics
- Plant Reproductive Biology
- Plant Genetic and Mutation Studies
- Chromosomal and Genetic Variations
- Renal and related cancers
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Plant Virus Research Studies
- Anomaly Detection Techniques and Applications
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Advanced Nanomaterials in Catalysis
- Human Pose and Action Recognition
Tianjin Medical University General Hospital
2011-2024
Henan Agricultural University
2007-2024
Northwestern Polytechnical University
2024
University of Shanghai for Science and Technology
2024
Tsinghua University
2023
Institute of Applied Technology
2023
Nanjing Agricultural University
2021
Nanjing Tech University
2020
Shandong Maternal and Child Health Hospital
2019
Michigan Technological University
2018
Abstract Background MicroRNAs (miRNAs) are a class of regulatory small RNAs (sRNAs) that down-regulate target genes by mRNA degradation or translational repression. Numerous plant miRNAs have been identified. Evidence is increasing for their crucial roles during development. In the globally important crop wheat ( Triticum aestivum L.), process which grains formed determines yield and end-use quality. However, little known about miRNA-mediated developmental regulation grain production. Here,...
The zinc-finger transcription factor PRDM1 (PR domain containing 1) plays key roles in the development of malignant lymphoma, leukaemia and some non-haematopoietic cancers, including breast cancer, colorectal cancer glioma. However, little is known regarding function progression lung cancer. Here, we found that expressed normal human epithelium but downregulated cells. Decreased expression correlates with poor prognosis Depletion cells promotes cellular invasion anoikis resistance vitro...
MicroRNAs (miRNAs) have been reported to play significant roles in non-small-cell lung cancer (NSCLC). However, the of microRNA (miR)-1915-3p NSCLC remain unclear. In this study, we aimed explore biological functions miR-1915-3p NSCLC.The expression and SET nuclear proto-oncogene (SET) tissues were examined by quantitative real-time PCR (qRT-PCR). Migratory invasive abilities tested wound healing transwell invasion assay. The direct target genes measured dual-luciferase reporter assay...
Preeclampsia is a major reason of morbidity and mortality in pregnant women perinatal fetus. Hence, it prime importance that diagnostic markers are defined to predict chances preeclampsia women. It has been previously shown microRNA (miRNA)-376c expression decreased the placenta patients at term. Even though this decrease was not mimicked pre-term stage, miR-376c plasma these as early second trimester. Plasma specimens were obtained from having unifetal gestation undergoing care between...
Abstract Background Argonaute proteins are key components of RNA interference (RNAi), playing important roles in RNA-directed gene silencing. Various classes genes have been identified from plants and might be involved developmental regulation. However, little is known about these wheat ( Triticum aestivum ). Results In this study, two full-length cDNAs were cloned wheat, designated as TaAGO1b TaAGO4 . The cDNA 3273 bp long encodes 868 amino acids, with a predicted molecular weight ~97.78...
The current clinical symptomatic therapy for Alzheimer's disease involves increasing acetylcholine levels in the brain by inhibiting acetylcholinesterase. However, effectiveness of acetylcholinesterase inhibitors decreases as progresses, leading to many side effects including over-inhibition other enzymes and hepatic injury. Herein, we investigate direct delivery a low-dose via human serum albumin nanoparticles brain. This novel nanodrug improved both spatial learning memory capability,...
Wilms' tumour gene 1 (WT1) is clearly recognized as a promoter in diversiform of human malignancies. Nevertheless, knowledge its expression, functions and potential molecular mechanisms non-small cell lung cancer (NSCLC) remains elusive.Differential expression WT1 mRNA protein between NSCLC normal tissues were assessed by analyzing RNA-seq data from Oncomine Human Protein Atlas, respectively. Subsequently, prognosis significance immune infiltration analyzed Kaplan-Meier plotter CIBERSORT. 60...