A5072144735- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Research on Leishmaniasis Studies
- SARS-CoV-2 and COVID-19 Research
- Trypanosoma species research and implications
- Immunotherapy and Immune Responses
- Viral Infections and Outbreaks Research
- Immune Cell Function and Interaction
- Immune cells in cancer
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Effects of Radiation Exposure
- Parasites and Host Interactions
- vaccines and immunoinformatics approaches
- Diversity and Career in Medicine
- Radiation Therapy and Dosimetry
- Diabetes and associated disorders
- Pneumonia and Respiratory Infections
- Inflammatory Biomarkers in Disease Prognosis
- Inflammation biomarkers and pathways
- Bacterial Infections and Vaccines
- Vaccine Coverage and Hesitancy
- Cancer Research and Treatments
- Career Development and Diversity
- Pancreatitis Pathology and Treatment
Biomedical Advanced Research and Development Authority
2022-2025
Office of Readiness and Response
2022
Infectious Disease Research Institute
2015-2017
Albert Einstein College of Medicine
2011-2014
Yeshiva University
2012
Key antigens of Leishmania species identified in the context host responses ‐exposed individuals from disease‐endemic areas were prioritized for development a subunit vaccine against visceral leishmaniasis (VL), most deadly form leishmaniasis. Two proteins—nucleoside hydrolase and sterol 24‐c‐methyltransferase, each which are protective animal models VL when properly adjuvanted— produced as single recombinant fusion protein NS (LEISH‐F3) ease antigen production broad coverage heterogeneous...
B7x (B7-H4 or B7S1) is an inhibitory member of the B7 family T cell costimulation. It expressed in low levels healthy peripheral tissues, such as lung epithelium, but overexpressed a variety human cancers with negative clinical associations, including metastasis. However, function context cancer, whether on cancer cells surrounding "host" has not been elucidated vivo. We used 4T1 metastatic breast model and knockout (B7x (-/-)) mice to investigate effect host tissue-expressed cancer. found...
B7-H1 (PD-L1) on immune cells plays an important role in T cell coinhibition by binding its receptor PD-1. Here, we show that both human and mouse intestinal epithelium express B7-H1-deficient mice are highly susceptible to dextran sodium sulfate (DSS)- or trinitrobenzenesulfonic acid (TNBS)-induced gut injury. deficiency during inflammation leads high mortality morbidity, which associated with severe pathological manifestations the colon, including loss of epithelial integrity overgrowth...
Abstract Coronavirus disease 2019 (COVID-19) epidemiology and product landscapes have changed considerably since onset of the pandemic. Safe effective vaccines therapeutics are available, but continual emergence severe acute respiratory syndrome coronavirus 2 variants introduce limitations in our ability to prevent treat disease. Project NextGen is a collaboration between Biomedical Advanced Research Development Authority, part Administration for Strategic Preparedness Response, National...
Vaccine development for vector-borne pathogens may be accelerated through the use of relevant challenge models, as has been case malaria. Because demonstrated biological importance vector-derived molecules in establishing natural infections, incorporating models into vaccine strategies increase accuracy predicting efficacy under field conditions. Until recently, however, there was no model available evaluation candidates against visceral leishmaniasis. We previously that a candidate...
B7x (B7-H4 or B7S1) is the seventh member of B7 family, and its in vivo function remains largely unknown. Despite new genetic data linking gene with autoimmune diseases, how exactly it contributes to peripheral tolerance autoimmunity unclear. In this study, we showed that protein was not detected on APCs T cells both human mice, which unique family. Because expressed some such as pancreatic β cells, used a CD8 cell-mediated diabetes model (AI4αβ) recognize an endogenous self-Ag, found mice...
Blood products are likely to be critical components of the medical response nuclear detonation, as hematopoietic subsyndrome acute radiation syndrome (H-ARS) includes depletion platelets and red blood cells that can lead lethal hemorrhage anemia. There is, however, only limited clinical information on use treat H-ARS. As currently configured, US supply cannot meet predicted surge in product demand is occur short-term possibly long-term event a large detonation. part Administration for...
Purpose The Sex Differences in Radiation Research workshop addressed the role of sex as a confounder radiation research and its implication real-world radiological nuclear applications.
Abstract B7x (B7-H4 or B7S1), a member of the B7 family, inhibits in vitro T cell proliferation and cytokine production by binding to an unidentified receptor on activated cells, but its vivo function remains largely unclear. We show that protein was expressed epithelial cells lung, not lymphoid tissues. To investigate role we determined susceptibility B7x-deficient (B7x−/−) mice lethal pulmonary infection with Streptococcus pneumoniae. B7x−/−, B7-H3–deficient, were significantly more...
The contribution of B cells to immunity against many infectious diseases is unquestionably important and well characterized. Here, we sought determine the role in induction T‐helper 1 (T H 1) CD4 + T upon vaccination with a tuberculosis (TB) antigen combined TLR4 agonist. We used B‐cell deficient mice (μMT −/− ), tetramer‐positive cells, markers memory “precursor” effector (MPECs), T‐cell adoptive transfers demonstrated that early antigen‐specific cytokine‐producing responses are unaffected...
Immunization strategies that generate either CD4 or CD8 T cell responses are relatively well described, but less is known with regard to optimizing regimens induce both and memory cells. Considering the importance of cells in control intracellular pathogens such as Leishmania donovani, we wanted identify vaccines could raise determine how configure immunization best combined protective response. We examined generated against vaccine antigen F3 following its administration recombinant form...