A5064743187- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Tuberculosis Research and Epidemiology
- T-cell and B-cell Immunology
- Adolescent Sexual and Reproductive Health
- Cytomegalovirus and herpesvirus research
- COVID-19 epidemiological studies
- Mental Health and Patient Involvement
- Reproductive Health and Contraception
- Food Security and Health in Diverse Populations
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Mental Health Treatment and Access
- Opinion Dynamics and Social Influence
- Mycobacterium research and diagnosis
- vaccines and immunoinformatics approaches
- Pneumonia and Respiratory Infections
- Herpesvirus Infections and Treatments
- Inflammasome and immune disorders
- Influenza Virus Research Studies
- Misinformation and Its Impacts
- School Choice and Performance
- Hepatitis B Virus Studies
Florida Institute for Human and Machine Cognition
2024-2025
University of Virginia
2021-2025
Carnegie Mellon University
2024
Bristol-Myers Squibb (United States)
2023-2024
Infectious Disease Research Institute
2012-2023
Biocom
2022-2023
Olympic Park Sports Medicine Centre
2023
University of Washington
2003-2022
Access to Advanced Health Institute
2022
Seattle University
2016-2020
We explored long-term health consequences of age at sexual initiation and abstinence until marriage to evaluate empirical support for the claim that postponing has beneficial effects.We analyzed data from 1996 National Sexual Health Survey, a cross-sectional study US adult population. compared outcomes among individuals who had initiated activity an early or late versus normative age. also whose first intercourse occurred before after marriage.Early was associated with various risk factors,...
Key antigens of Leishmania species identified in the context host responses ‐exposed individuals from disease‐endemic areas were prioritized for development a subunit vaccine against visceral leishmaniasis (VL), most deadly form leishmaniasis. Two proteins—nucleoside hydrolase and sterol 24‐c‐methyltransferase, each which are protective animal models VL when properly adjuvanted— produced as single recombinant fusion protein NS (LEISH‐F3) ease antigen production broad coverage heterogeneous...
Aluminum salts, developed almost a century ago, remain the most commonly used adjuvant for licensed human vaccines. Compared to more recently vaccine adjuvants, aluminum adjuvants such as Alhydrogel are heterogeneous in nature, consisting of 1-10 micrometer-sized aggregates nanoparticle oxyhydroxide fibers. To determine whether particle size and aggregated state affects its activity, we scalable, top-down process produce stable nanoparticles (nanoalum) from clinical by including poly(acrylic...
Background. Recent advances in rational adjuvant design and antigen selection have enabled a new generation of vaccines with potential to treat prevent infectious disease. The aim this study was assess whether therapeutic immunization could impact the course Mycobacterium tuberculosis infection use candidate vaccine antigen, ID93, formulated synthetic nanoemulsion adjuvant, GLA-SE, administered combination existing first-line chemotherapeutics rifampicin isoniazid.
Glucopyranosyl lipid adjuvant-stable emulsion (GLA-SE) is a synthetic adjuvant TLR4 agonist that promotes potent poly-functional T(H)1 responses. Different agonists may preferentially signal via MyD88 or TIR-domain-containing adapter inducing IFN-beta (TRIF) to exert effects; however, the contribution of and TRIF signaling induction polyclonal responses by adjuvants has not been studied in vivo. To determine whether GLA-SE signals through TRIF, we evaluated immune response against candidate...
With over eight million cases of tuberculosis each year there is a pressing need for the development new vaccines against Mycobacterium tuberculosis. Subunit consisting recombinant proteins are an attractive vaccine approach due to their inherent safety compared attenuated live and uniformity manufacture. Addition properly formulated TLR agonist-containing adjuvants protein enhances antigen-specific CD4+ T cell response characterized by IFN-γ TNF, both which critical control TB. We have...
The synthetic TLR4 agonist glucopyranosyl lipid adjuvant (GLA) is a potent Th1‐response‐inducing when formulated in squalene oil‐in‐water emulsion (SE). While the innate signals triggered by engagement are well studied, contribution of SE remains unclear. To better understand effect on properties GLA‐SE, we compared and adaptive immune responses elicited immunization with different formulations: GLA without oil, alone or combination, mice. Within response to adjuvants, only GLA‐SE displayed...
For nearly a century, aluminum salts have been the most widely used vaccine adjuvant formulation, and thus established history of safety efficacy. Nevertheless, for extremely challenging disease targets such as tuberculosis or HIV, activity may not be potent enough to achieve protective Adsorption TLR ligands facilitates enhanced activity, in human papilloma virus Cervarix®. However, some TLR7/8 agonist imidazoquinolines do efficiently adsorb salts. The present report describes formulation...
In Spring 2021, the highly transmissible SARS-CoV-2 Delta variant began to cause increases in cases, hospitalizations, and deaths parts of United States. At time, with slowed vaccination uptake, this novel was expected increase risk pandemic resurgence US summer fall 2021. As part COVID-19 Scenario Modeling Hub, an ensemble nine mechanistic models produced 6-month scenario projections for July-December 2021 These estimated substantial resurgences across resulting from more variant, projected...
Abstract Synthetic biology has allowed for the industrial production of supply-limited sesquiterpenoids such as antimalarial drug artemisinin and β-farnesene. One only unmodified animal products used in medicine is squalene, a triterpenoid derived from shark liver oil, which when formulated into an emulsion vaccine adjuvant to enhance immune responses licensed vaccines. However, overfishing depleting deep-sea populations, leading potential supply problems squalene. We chemically generated...
The activating natural killer (NK) cell receptor Ly49H recognizes the mouse cytomegalovirus (MCMV) m157 glycoprotein expressed on surface of infected cells and is required for protection against MCMV. Although has previously been shown to signal via DAP12, we now show that must also associate with DAP10 optimal function. In absence enables Ly49H-mediated killing m157-bearing target cells, proliferation in response MCMV infection, partial DAP10-deficient Ly49H+ NK expressing only Ly49H–DAP12...
Two claims of the Causal Attitude Network (CAN) model and descendent Entropy framework (AE) are indicative significant theoretical hurdles facing psychological network modeling efforts attitudes. The first claim is that dynamics change in an Ising-like attitude network, under perturbation any one single node, can be inferred from static attributes said node. second models attitudes with will maximize both attitudinal consistency accuracy when within small-world topological regime. claim,...