A5102948107- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Immunodeficiency and Autoimmune Disorders
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Treatments and Mutations
- Signaling Pathways in Disease
- Dialysis and Renal Disease Management
- Venomous Animal Envenomation and Studies
- S100 Proteins and Annexins
- Nutrition and Health in Aging
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- TGF-β signaling in diseases
- Immune cells in cancer
- Cancer Research and Treatments
- Climate Change and Health Impacts
- Cell Adhesion Molecules Research
- Intravenous Infusion Technology and Safety
- Body Composition Measurement Techniques
- Atherosclerosis and Cardiovascular Diseases
- Fibroblast Growth Factor Research
- Pharmacological Effects and Toxicity Studies
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Adipokines, Inflammation, and Metabolic Diseases
Ewha Womans University
2008-2021
Kyungpook National University Hospital
2021
Seoul National University
2016-2021
Samsung Medical Center
2020
Sungkyunkwan University
2020
Eulji University
2015
Ewha Womans University Medical Center
2013
Yonsei University
2009
Inha University
2003-2005
Inha University Hospital
2003
We provide detailed mechanisms of Ahnak-mediated potentiation transforming growth factor β (TGFβ) signaling, which leads to a negative regulation cell growth. show that Smad3 interacts with Ahnak through MH2 domain and stimulates localization into nucleus leading potentiating TGFβ-induced transcriptional activity R-Smad. Moreover, overexpression resulted in retardation cycle arrest downregulation c-Myc cyclin D1/D2. describe results from analyses Ahnak−/− mouse model expressing middle T...
NADPH oxidase (Nox) isozymes that generate intracellular reactive oxygen species (ROS) and Toll-like receptor 2 (TLR2), an inflammatory mediator, are both involved in the development of atherosclerotic lesions. To identify molecular connection between TLR2 Nox vascular remodelling, we analysed generation ROS pro-inflammatory cytokines aortic smooth muscle cells from Nox1-deficient mice response to synthetic triacylated lipoprotein Pam3CSK, a agonist. We showed signalling stimulates...
Abstract AHNAK is known to be a tumor suppressor in breast cancer due its ability activate the TGFβ signaling pathway. However, role of lung development and progression remains unknown. Here, Ahnak gene was disrupted determine effect on tumorigenesis mechanism by which it triggers investigated. First, protein expression determined decreased human adenocarcinomas compared with matched nonneoplastic tissues. Then, Ahnak−/− mice were used investigate pulmonary tumorigenesis. showed increased...
Abstract In adipose tissue, agonists of the β3-adrenergic receptor (ADRB3) regulate lipolysis, lipid oxidation, and thermogenesis. The deficiency in thermogenesis induced by neuroblast differentiation-associated protein AHNAK white tissue (WAT) mice fed a high-fat diet suggests that may stimulate energy expenditure via development beige fat. Here, we report promoted browning thermogenic gene expression WAT but not brown stimulated with ADRB3 agonist CL-316243. Consistent increased...
Ahnak protein acts as a scaffold networking phospholipase C-γ and kinase C-α, which subsequently stimulate an extracellular signal-regulated (Erk) pathway. In mouse aortic smooth muscle cells (ASMCs), the activation of signalling cascade ultimately promotes cell migration through unknown mechanism. We aimed to dissect Ahnak-mediated network involved in ASMCs.Migration ASMCs from wild-type mice was significantly increased by platelet-derived growth factor (PDGF) stimulation transwell chamber...
The AHNAK nucleoprotein has been determined to exert an anti-obesity effect in adipose tissue and further inhibit adipogenic differentiation. In this study, we examined the role of regulating hepatic lipid metabolism prevent diet-induced fatty liver. Ahnak KO mice have reportedly exhibited reduced fat accumulation liver decreased serum triglyceride (TG) levels when provided with either a normal chow diet or high-fat (HFD). Gene expression profiling was used identify novel factors that could...
Because gastrointestinal tract is not sterile, primary culture has contamination risk despite of massive washing with antimicrobial media. Microbial can play a key role in initial failure during biopsy-derived tumor culture.Tumor tissue was acquired from esophageal and gastric tumors using endoscopic biopsy. Three-dimensional cultures were performed, separated spheroids cultured media for 7 to 10 days then transferred Matrigel (Corning Inc.). We investigated factors patterns fungal...
연구 대상자의 건강보험 치석제거 수진에 영향을 미치는 요인을 알아 보기 위하여, 2014년 2월 10일부터 28일까지 수도권(서울, 경기 인천)에 거주하는 만 20세 이상 60세 미만의 성인 238명을 대상으로 설문조사하여 다음과 같은 결론을 얻었다. 치석제거에 대한 인식을 조사한 결과 제도에 개선점은 연간횟수가, 인지도는 보통이다가 그리고 지지도는 그렇다가 가장 많은 분포를 차지하였다. 치석제거를 받지 않은 이유로는 시간이 없어서가 많았다. 수진 의향은 여자가, 정기적 구강검진을 받는 경우, 구강보건교육 경험 이 있는 경험이 경우에 유의미하게 높았다. 로지스틱 다중회귀분석결과, 요인은 소득 (OR, 3.55; p<0.05), 3.06; 구강검진 2.63; p<0.05) 순으로 나타났다. 이상의 결과로 볼 때, 치석제거의 수진율을 높이기 위해서는 홍보 및 구강보건교육을 통하여 새로운 제도의 인지도를 높이고, 정기적인 구강검진으로 중요성을 강조할 필요가 있다. The aim...
Development of Anthropometry-Based Equations for the Estimation Total Body Water in KoreansFor developing race-specific anthropometry-based total body water (TBW) equations, we measured TBW using bioelectrical impedance analysis (TBWBIA) 2,943 healthy Korean adults.Among them, 2,223 were used as a reference group.Two equations (TBWK1 and TBWK2) developed based on age, sex, height, weight.The adjusted R 2 was 0.908 TBWK1 0.910 TBWK2.The remaining 720 subjects validation our results.Watson...
Abstract Reactive oxygen species (ROS) play important roles as second messengers in a wide array of cellular processes including differentiation stem cells. We identified Nox4 the major ROS-generating enzyme whose expression is induced during embryoid body (EB) into cells all three germ layers. The role was examined using pluripotent (iPSCs) generated from knockout (Nox4 −/− ) mouse. Differentiation markers showed significantly reduced levels consistent with importance Nox4-generated ROS...
<p>Representative IHC images of lung cancer tissues corresponding to indicated grades for AHNAK expression</p>
<p>Lung weights in Ahnak-/- mice and WT at 6, 18, 40 weeks of age.</p>
<p>Representative H&E images of Ahnak-/- and WT lungs in embryonic day 18.5 postnatal 1.</p>
<p>Excessive accumulation of collagen in Ahnak-/- lungs as measured by Masson's trichrome staining.</p>
<p>Supplementary figure legends</p>
<p>The activation of the IGF-1 and EGF signaling pathways in Ahnak-/- lungs.</p>
<div>Abstract<p>AHNAK is known to be a tumor suppressor in breast cancer due its ability activate the TGFβ signaling pathway. However, role of AHNAK lung development and progression remains unknown. Here, Ahnak gene was disrupted determine effect on tumorigenesis mechanism by which it triggers investigated. First, protein expression determined decreased human adenocarcinomas compared with matched nonneoplastic tissues. Then, Ahnak<i><sup>−/−</sup></i> mice...
<p>Supplementary figure legends</p>
<p>Representative IHC images of lung cancer tissues corresponding to indicated grades for AHNAK expression</p>
<p>Lung weights in Ahnak-/- mice and WT at 6, 18, 40 weeks of age.</p>