A5002602908- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Pulmonary Hypertension Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Prince of Songkla University
2021
Khon Kaen University
2013-2015
Graduate School USA
2015
Centre for Research and Development
2015
Medical Diagnostic Laboratories (United States)
2015
Objective To evaluate an immunochromatographic (IC) strip assay for Hb Bart's as a routine screening test α-thalassaemia in area with high prevalence of thalassaemia and haemoglobinopathies. Methods A total 300 adult screen positive blood specimens were collected at ongoing programme northeast Thailand. Routine was done using red cell indices, osmotic fragility, dichlorophenolindophenol tests. The IC haemoglobin performed on all samples. result evaluated against genotypes determined standard...
Patients with nontransfusion-dependent thalassemia (NTDT) do not require regular blood transfusion for survival but may encounter several complications that contribute to morbidity and mortality. We report the molecular heterogeneity hematological features of NTDT in 312 adult patients northeast Thailand. Hemoglobin (Hb) DNA analyses identified 177 subjects Hb E-β-thalassemia, 1 homozygous β0-thalassemia 134 H, AEBart's EEBart's diseases. For β-thalassemia, 12 different mutations including...
Pulmonary hypertension is one of the major complications in patients with non-transfusion-dependent thalassemia (NTDT). Patients NTDT have distinct genetic subgroups. Therefore, effects different genotype groups on pulmonary risk were assessed.A cross-sectional study was conducted aged ≥ 10 yr old at Srinagarind University Hospital and Udonthani Hospital, Thailand. defined as peak tricuspid regurgitation velocity > 2.9 m/s by trans-thoracic echocardiography. Clinical characteristics...
IntroductionPulmonary hypertension (PH) is a major complication in patients with non-transfusion-dependent thalassemia (NTDT). The risk score was developed to be screening test for PH these patients.MethodsA multi-center study conducted NTDT aged ≥10 years old. defined as tricuspid regurgitation velocity >2.9 m/s by echocardiography. clinical parameters significantly associated were entered into the logistic regression model.ResultsThe E-SAAN included (1) age >35 (2.5 points), (2) time after...
Background: Delta-chain (δ-chain) variants are a group of rare hemoglobin (Hb) resulting from mutations within the δ-globin gene. Although quantification Hb A2 levels is useful screening tool for beta-thalassemia trait, coinheritance gene mutation can lead to misinterpretation diagnostic results. Objective: To identify an unreported variant in Thailand and develop high resolution melting (HRM) curve assay four chain found Thai population. Materials Methods: Allele-specific polymerase...