A5101697576- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Hematopoietic Stem Cell Transplantation
- Immunodeficiency and Autoimmune Disorders
- Classical Philosophy and Thought
- Blood groups and transfusion
- Historical and Literary Analyses
- Blood disorders and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Lymphoblastic Leukemia research
- Antiplatelet Therapy and Cardiovascular Diseases
- Obstructive Sleep Apnea Research
- Organic Chemistry Synthesis Methods
- Polyomavirus and related diseases
- Inflammatory Biomarkers in Disease Prognosis
- Anesthesia and Neurotoxicity Research
- Classical Antiquity Studies
- Chronic Myeloid Leukemia Treatments
- Neurological Complications and Syndromes
- Forensic Entomology and Diptera Studies
- Sepsis Diagnosis and Treatment
- Cardiovascular Effects of Exercise
- Cardiac Ischemia and Reperfusion
- Cell Adhesion Molecules Research
Helios Klinikum Erfurt
2016-2021
Jena University Hospital
2007-2016
Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
2015
University of Tübingen
2010
Friedrich Schiller University Jena
2002-2007
Martin Luther University Halle-Wittenberg
1999
Abstract Introduction This study was carried out to determine whether interactions of cell activation, shear stress and platelets at sites endothelial injury explain the paradoxical maldistribution activated leukocytes during sepsis away from local infection towards disseminated leukocyte accumulation remote sites. Methods Human umbilical venous cells (HUVEC) polymorphonuclear neutrophils (PMN) were with lipopolysaccharide 100 10 ng/ml achieve adhesion molecule patterns as have been reported...
Summary Relapse of acute leukemia is a frequent complication with uncertain outcome and poorly defined risk factors. From 1621 patients entered into two prospective clinical trials (AML02; n = 740 AML04; 881), 74.2% reached complete remission (CR) 1 after induction(s) 59 additional induction ± hematopoietic cell transplantation (HCT). Of the non-refractory patients, 48.4% median age 63 (range 17–85) years relapsed. Relapses occurred within 6 months CR in 46.5%, between 7 18 38.7%, 14.8%...
For rehabilitation training it is recommended that the intensity of exercise should be distinctly below individual anaerobic threshold (IAT). We investigated platelet activity, reactivity and platelet-leukocyte conjugate formation following a stardardized treadmill (TR) ergometer test at 90% IAT for 60-120 min. Seventeen healthy male non-smokers underwent TR. Blood samples were taken after 30-min rest, immediately exercise, 2 h completion. Platelets detected flow cytometrically by CD41 in...
We report a chronic persistent Parvovirus B19 (PVB19) infection despite long-term immunoglobulin substitution intravenous (IVIG) and tapering of immune-suppressive therapy in 41-year-old patient after allogeneic haematopoietic stem cell transplantation (alloHSCT) due to steroid-refractory graft versus host disease (GvHD).More than 18 month alloHSCT the acquired de novo transfusion-dependent pure red aplasia (PRCA) PVB19 infection. Despite prompt GvHD-directed application various IVIG...
Platelet flow cytometry is restricted by spontaneous platelet activation in unfixed samples or significant alterations of performance caused the use fixatives. Aim this study was to evaluate new stabilizer ThromboFix™ for clinical diagnostics.Methods: Whole blood with without addition a weak (ADP) strong (TRAP-6) agonist were fixed either ThromboFix paraformaldehyde (PFA) and stored different periods time up 7 days. Samples then incubated CD41 CD62P CD42b CD45 monoclonal antibodies analyzed...
Diabetes mellitus alters blood coagulation and platelet function which supports the suggestion that diabetes is a hypercoagulable state. Firstly aim of study was to investigate if differences in activity, reactivity platelet-leukocyte conjugate (PLC) formation can be observed subjects with IDDM; secondly, seen between diabetic control group concerning exercise-induced changes activation formation; thirdly, different types exercise lead patterns activation. Sixteen IDDM 16 controls underwent...
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Purpose: To describe the epidemiology of acute respiratory distress syndrome (ARDS) in a Brazilian ICU.Methods: This prospective observational, non-interventional study, included all consecutive patients with ARDS criteria [1] admitted ICU tertiary hospital, between January 1997 and September 2001.Were collected fashion following variables: age, gender, APACHE II score at admission diagnosis, cause ARDS, presence AIDS, cancer immunosuppression, occurrence barotrauma, performance...