A5019187509- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Diabetes Treatment and Management
- Potassium and Related Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Physics and Engineering Research Articles
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Connective tissue disorders research
- Parathyroid Disorders and Treatments
- Digital Innovation in Industries
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- IL-33, ST2, and ILC Pathways
- Cardiac pacing and defibrillation studies
- Fibroblast Growth Factor Research
- GDF15 and Related Biomarkers
- Coronary Interventions and Diagnostics
- Mindfulness and Compassion Interventions
- Medication Adherence and Compliance
Medical University of Vienna
2007-2025
Ludwig Boltzmann Institute for Digital Health and Prevention
2024
Ludwig Boltzmann Institute for Cancer Research
2024
Arbeitsgemeinschaft für Klinische Ernährung
2020-2022
Jena University Hospital
2016
Background: In the era of personalized medicine, tools for risk stratification after cardiovascular interventions are crucial to reduce mortality and morbidity, especially in aging population. Biomarker-based approaches, particular, have gained significant importance. Mid-regional pro-adrenomedullin (MR-proADM) represents an easily assessable biomarker that mirrors cardiac function fibrosis. Therefore, we aimed investigate prognostic potential MR-proADM patients undergoing elective surgery....
While the prognosis of patients presenting with de novo atrial fibrillation (AF) during acute phase myocardial infarction has been controversially discussed, it seems intuitive that affected individuals have an increased risk for both thrombo-embolic events and mortality. However, profound data on long-term outcome this highly vulnerable patient population are not available in current literature. Therefore, we aimed to investigate impact AF associated anti-thrombotic treatment strategies...
Secondary prevention is crucial for reducing morbidity and mortality in patients following acute myocardial infraction (MI). However, adherence to cardiac rehabilitation (CR) pharmacotherapy remains suboptimal despite strong guideline recommendations. This study investigated the CR, dual antiplatelet therapy (DAPT), statins MI evaluated their impact on patient outcomes from a nationwide perspective Austria.
Background: The incidence of atrial fibrillation (AF) in patients with heart failure preserved ejection fraction (HFpEF) is high. Impaired left (LA) function a major determinant HFpEF. However, the extent electrical LA tissue degeneration HFpEF unknown. Therefore, we sought to investigate amount arrhythmogenic and fibrotic presenting for AF ablation. Methods: We prospectively screened consecutive first time HFA-PEFF score was used identify patients. Bipolar high-density voltage mapping...
Atrial fibrillation (AF) represents the most common cardiac arrhythmia in daily clinical practice and substantially impacts affected patients by elevation of both morbidity mortality. Previous investigations proved that inflammatory processes are closely linked to this multifactorial pathogenesis-especially autoreactive CD4+CD28null T cells received in-depth attention.Consequently, a potential pathophysiological pathway impact lymphocytes on development progression AF can be...
We report a chronic persistent Parvovirus B19 (PVB19) infection despite long-term immunoglobulin substitution intravenous (IVIG) and tapering of immune-suppressive therapy in 41-year-old patient after allogeneic haematopoietic stem cell transplantation (alloHSCT) due to steroid-refractory graft versus host disease (GvHD).More than 18 month alloHSCT the acquired de novo transfusion-dependent pure red aplasia (PRCA) PVB19 infection. Despite prompt GvHD-directed application various IVIG...
Background Fibroblast growth factor 23 (FGF-23) is crucial in regulating phosphate and vitamin D metabolism moreover associated with an increased cardiovascular risk. The specific objective of this study was to investigate the influence FGF-23 on outcomes, including hospitalization for heart failure (HHF), postoperative atrial fibrillation, death, unselected patient population after cardiac surgery. Methods Results Patients undergoing elective coronary artery bypass graft and/or valve...
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve cardiovascular outcomes in patients with type diabetes mellitus (T2DM) and heart failure (HF). In consideration of emerging evidence that there are clinically relevant sex-related differences the course T2DM subsequent outcomes, it is unknown if SGLT2i therapy sex-independently utilized daily clinical practice.
Heart failure with reduced ejection fraction (HFrEF) constitutes a global health issue. While proinflammatory cytokines proved to have pivotal role in the development and progression of HFrEF, less attention has been paid cellular immunity. Regulatory T lymphocytes (Tregs) seem an important induction maintenance immune homeostasis. Therefore, we aimed investigate impact Tregs on outcome HFrEF.We prospectively enrolled 112 patients HFrEF performed flow cytometry for cell phenotyping....
Abstract Background GDF-15 (growth/differentiation factor 15) is induced by myocardial stretch, volume overload, inflammation, and oxidative stress. Its expression tightly linked with cardiovascular events as well the risk for major bleeding all-cause mortality. The present study aimed to elucidate prognostic potential of in patients after cardiac surgery. Methods A total 504 undergoing elective valve and/or coronary artery bypass graft surgery were prospectively enrolled. levels measured...
The study investigated the prognostic value of soluble urokinase plasminogen activator receptor (suPAR) in patients undergoing cardiac surgery and calculated a simplified biomarker score comprising suPAR, N-terminal pro B-type natriuretic peptide (NT-proBNP) age.Biomarkers were assessed cohort 478 elective surgery. After median follow-up 4.2 years, total 72 (15.1%) died. SuPAR, NT-proBNP age independent prognosticators mortality multivariable Cox regression model after adjustment for...
Abstract Background Postoperative atrial fibrillation (POAF) represents a common complication after cardiac surgery associated with major adverse events and poor patient outcome. Tools for risk stratification of this arrhythmia remain scarce. Atrial natriuretic peptide (ANP) an easily assessable biomarker picturing function strain; however, its prognostic potential on the development POAF has not been investigated so far. Methods Within present investigation, 314 patients undergoing elective...
Personalized risk stratification within the ageing society after acute coronary syndrome (ACS) remains scarce but in urgent need. Increased platelet activity together with inflammatory activation play a key role during ACS. We aimed to evaluate age-specific prognostic potential of lymphocyte ratio (PLR) on long-term cardiovascular mortality ACS.Patients presenting ACS admitted Vienna General Hospital between December 1996 and January 2010 were enrolled clinical registry including assessment...
Postoperative atrial fibrillation (POAF) represents a common complication after cardiac surgery that is associated with unfavourable clinical outcome. Identifying patients at risk for POAF crucial but challenging. This study aimed to investigate the prognostic potential of speckle-tracking echocardiography on and fatal adverse events from long-term perspective.A total 124 undergoing elective were prospectively enrolled underwent preoperative echocardiography. Patients followed occurrence...
Postoperative atrial fibrillation (POAF) represents the most common complication following cardiac surgery. Approximately one-third of patients experiencing POAF transition to within a year, challenging notion as merely transient event. Soluble ST2 (sST2) is an established biomarker regarding fibrosis and myocardial stretch, however, its role in predicting onset remains unclear.
Abstract Background The global prevalence of prediabetes and diabetes is increasing, highlighting an urgent public health challenge. While the cardiovascular (CV) risk well studied, profound data on CV in patients with heart failure (HF) remain scarce current literature. Therefore, we aimed to investigate relationship common HF associated events such as all-cause, death hospitalization for (HHF) reduced ejection fraction (HFrEF). Methods Patients HFrEF who were admitted a tertiary academic...