A5077687204- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Protease and Inhibitor Mechanisms
- Alzheimer's disease research and treatments
- Venous Thromboembolism Diagnosis and Management
- Prostate Cancer Treatment and Research
- Stroke Rehabilitation and Recovery
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Functional Brain Connectivity Studies
- S100 Proteins and Annexins
- Cardiac Structural Anomalies and Repair
- Chromosomal and Genetic Variations
- Cell Adhesion Molecules Research
- Ginger and Zingiberaceae research
- Peptidase Inhibition and Analysis
- Mast cells and histamine
- Infectious Encephalopathies and Encephalitis
- Atrial Fibrillation Management and Outcomes
- Health and Well-being Studies
- Vascular Malformations Diagnosis and Treatment
Central Baptist Hospital
2024-2025
Banner - University Medical Center Tucson
2024
University of Arizona
2024
University of Kentucky
2016-2023
Universitätsklinikum Erlangen
2013-2019
Friedrich-Alexander-Universität Erlangen-Nürnberg
2012-2019
Methodist Hospital
2016
University of Washington
2016
University of Pennsylvania
2016
This study aimed to assess the applicability of miR-375 in combination with soluble urokinase plasminogen activator receptor (suPAR) protein as a diagnostic and/or prognostic biomarker for prostate cancer (PCa) patients. levels by qRT-PCR and suPAR ELISA were evaluated serum samples from 146 PCa patients, 35 benign hyperplasia (BPH) patients 18 healthy controls. Antigen differed between controls or BPH whereas (p < 0.001). Additionally, Gleason sum groups GS = 7 versus > 7, higher latter...
Background Left ventricular assist devices (LVADs) are used as definitive therapy or a bridge to heart transplant in patients with advanced failure. Thromboembolic complications such acute ischemic stroke (AIS) common among LVAD support. This study aims evaluate the current evidence on efficacy and safety of mechanical thrombectomy (MT) AIS due large vessel occlusions (LVO) LVAD-support. Methods A comprehensive systematic review was conducted PubMed, Embase, Scopus find observational studies...
Small cerebral vascular disease (SCeVD) demonstrated by white matter hyperintensity (WMH) on MRI contributes to the development of dementia in Alzheimer's (AD), but it has not been possible correlate onset, severity, or protein components SCeVD with characteristics WMH living patients.Plasma endothelial-derived exosomes (EDEs) were enriched two-step immunoabsorption from four groups participants no clinical evidence cerebrovascular disease: cognitively normal (CN) without (CN SCeVD, n = 20),...
Subcortical white matter hyperintensities (WMHs) in the aging population frequently represent vascular injury that may lead to cognitive impairment. WMH progression is well described, but factors underlying regression remain poorly understood. A sample of 351 participants from Alzheimer's Disease Neuroimaging Initiative 2 (ADNI2) was explored who had volumetric quantification, structural brain measures, and measures (memory executive function) at baseline after approximately years. Selected...
Background: Alzheimer’s disease (AD) pathology and hypertension (HTN) are risk factors for development of white matter (WM) alterations might be independently associated with these in older adults. Objective: To evaluate the independent synergistic effects HTN AD on WM alterations. Methods: Clinical measures cerebrovascular were collected from 62 participants University Kentucky Disease Center studies who also had cerebrospinal fluid (CSF) sampling MRI brain scans. CSF Aβ 1-42 levels...
MIR143 is pathologically downregulated and may function as a tumor suppressor in prostate cancer. Likewise, the urokinase plasminogen activator receptor (UPAR) overexpressed carcinoma, representing negative prognostic marker putative therapeutic target gene. In this paper, we establish UPAR new direct of MIR143. Luciferase reporter gene constructs identify one two silico-predicted binding sites functionally relevant for to 3' UTR, and, concomitantly, transfection reduces protein levels...
The objective was to determine the mRNA expression and protein levels of uPA system components in tissue specimens serum samples, respectively, from prostate cancer (PCa) patients assess their association with clinicopathological parameters overall survival (OS). uPA, its receptor (uPAR), inhibitor type 1 (PAI-1) were analyzed corresponding malignant adjacent nonmalignant 132 PCa by quantitative PCR. Preoperative samples 81 for antigen members ELISA. RNA displayed significant correlations...
ABSTRACT BACKGROUND AND PURPOSE Interpreting the clinical significance of moderate‐to‐severe global cerebral atrophy (GCA) is a conundrum for many clinicians, who visually interpret brain imaging studies in routine practice. GCA may be attributed to normal aging, Alzheimer's disease (AD), or cerebrovascular (CVD). Understanding relationships with AD, and CVD important accurate diagnosis treatment decisions cognitive complaints. METHODS To elucidate relative associations age, white matter...
Previous research has indicated that miR-107 may play important roles in both metabolism and AD pathogenesis be modulated by "fibrates" (PPAR-alpha agonists). Fibrates increase expression, leading to down-regulation of BACE1 protein. We evaluated the safety efficacy gemfibrozil administration predementia Alzheimer's disease a parallel-design, double-blind, placebo-controlled clinical trial funded NIH/NIA R01 AG042419 registered on clinicaltrials.gov NCT02045056. Patients with pAD, MCI, or...
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Abstract Background When and how to communicate effectively the results of genetic biomarker based prediction, detection, quantification brain substrates dementia involve important ethical legal issues critical for precision medicine. The urgency issue has increased as People Living with Dementia (PLwD) Risk (PwRD) can access direct consumer testing, amyloid targeting drugs, clinical PET scans. To address need effective dissemination consultation, an advisory group was convened that welcomes...
To shed light on the COVID-19 related encephalitis and its associated CSF imaging findings
Abstract Background: Members of the urokinase-type plasminogen activator (uPA) system play an important role in tumor progression and angiogenesis different human malignancies including breast, kidney, colon, stomach prostate cancer (PCa). The objective this study was to determine mRNA expression protein levels uPA components tissue specimens serum samples, respectively, from patients with PCa, assess their potential association clinic-pathological parameters overall survival (OS). Material...