A5082880858- Urologic and reproductive health conditions
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Cancer and Skin Lesions
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Sarcoma Diagnosis and Treatment
- Tracheal and airway disorders
- Breast Lesions and Carcinomas
- Renal cell carcinoma treatment
- Cancer-related gene regulation
- Cardiac tumors and thrombi
- Polyomavirus and related diseases
- Lung Cancer Research Studies
- Cardiovascular Effects of Exercise
- Thyroid Cancer Diagnosis and Treatment
- Renal and related cancers
- Vascular Anomalies and Treatments
- Pituitary Gland Disorders and Treatments
- Genomics and Rare Diseases
- Mechanical Circulatory Support Devices
- Occupational and environmental lung diseases
- Cardiomyopathy and Myosin Studies
- Gyrotron and Vacuum Electronics Research
- Antifungal resistance and susceptibility
Jackson Memorial Hospital
2025
University of Miami
2020-2024
Sylvester Comprehensive Cancer Center
2021-2024
Emory University Hospital
2024
University of Miami Hospital
2023
University of Michigan
2017-2018
Geleophysic Dysplasia-1 (GD1) is an autosomal recessive disorder caused by ADAMTSL2 variants. It characterized distinctive facial features, limited joint mobility, short stature with brachydactyly, and the potential for life-threatening cardiovascular respiratory complications. The clinical spectrum spans from perinatal lethality to milder phenotypes in adult survivors, manifesting a heterogeneity. Adamtsl2–/– mouse model dies perinatally hinders further functional investigation. In this...
Abstract Objectives There are 2 grading approaches to radical prostatectomy (RP) in multifocal cancer: Grade Group (GG) and percentage of Gleason pattern 4 (GP4%). We investigated whether RP GG GP4% generated by global vs individual tumor correlate differently with biochemical recurrence. Methods reviewed 531 specimens GG2 or GG3 cancer. Each was scored separately assessment volume GP4%. Global grade were assigned combining 3 volumes for all tumors. Correlation methods recurrence assessed...
A focal adenomatoid-microcystic pattern is not uncommon in peritoneal mesothelioma, but tumors composed almost exclusively of this are distinctly rare and have been well characterized. small subset mesotheliomas (mostly children young adults) characterized by gene fusions including EWSR1/FUS::ATF1, EWSR1::YY1, NTRK ALK rearrangements, often epithelioid morphology. Herein, we describe five mesothelial neoplasms (identified via molecular screening seven histologically similar tumors) that pure...
Invasive aspergillosis is the most common invasive mold infection following a hematopoietic cell transplant. Widespread use of antifungal prophylaxis has led to increasing incidence cryptic Aspergillus species. calidoustus one those emerging species and notorious for multidrug resistance antifungals. Here, we report case disseminated A. in stem transplant recipient who was successfully treated with combination therapy that included novel antifungal.
Background: Previous studies have shown that aberrant activation of the Wnt/β-catenin pathway is associated with many malignant neoplasms. This includes some soft-tissue sarcoma phenotypes, most notably synovial sarcoma, implicating potential targets for novel molecular therapies. Objective: We investigate level present in leiomyosarcomas relative to sarcomas, using expression LEF1 and β-catenin as surrogates. Methods: Cancer outlier profile analysis was performed on messenger RNA datasets...
Prostatic ductal adenocarcinoma (PDA) has historically been considered to be an aggressive subtype of prostate cancer.To investigate if PDA is independently associated with worse biochemical recurrence (BCR)-free survival after radical prostatectomy.A review 1584 prostatectomies was performed grade, stage, and assess margin status in each tumor nodule. Radical localized (ie, those lacking metastasis) the nodule highest grade stage worst were matched prostatic acinar according status. The...
Critical airway stenosis is challenging for surgeons and anesthesiologists to secure a reliable ventilation. The use of venovenous (VV)-extracorporeal membrane oxygenation (ECMO) has been described as strategy provide adequate gas exchange in such instances. We present case young female with complex paratracheal mass significantly compressing the trachea; planned intraoperative VV-ECMO was instituted allow safe orotracheal intubation double-lumen endotracheal tube lung isolation tumor resection.
Intraductal spread of urothelial carcinoma (UC) is not an uncommon finding in bladder cancer that requires appropriate clinical management. The presence prostatic stromal invasion non-muscle-invasive upstages the disease, necessitating cisplatin-based neoadjuvant chemotherapy and subsequent cystroprostatectomy. However, identification can be challenging, especially biopsy transurethral resection specimens. We assess utility D2-40, CK5/6, high-molecular-weight cytokeratin (HMWCK)...
Increasing percentages of Gleason pattern 4 (GP4%) in radical prostatectomy (RP) correlate with an increased likelihood nonorgan-confined disease and earlier biochemical recurrence (BCR). However, there are no detailed RP studies assessing the impact GP4% corresponding tumor volume (TV) on extraprostatic extension (EPE), seminal vesicle (SV) invasion (SV+), positive surgical margin (SM) status (SM+).In 1301 consecutive RPs, we analyzed each nodule (TN) for TV, Grade Group (GG), presence...
We present a case of an ectopic breast adenocarcinoma the vulva with metastatic local recurrence and total follow-up period 19 years, longest documented in literature to our knowledge. Following surgical excision, radiation therapy hormonal treatment after recurrence, patient has remained disease free. This demonstrates potential for malignant transformation accessory tissue highlights importance close surveillance regular physical examinations patients history malignancy.
Effect of tumor nodule (TN) location in the prostate on adverse radical prostatectomy (RP) outcomes is not well studied contemporary cohorts.To investigate significance TN with respect to extraprostatic extension (EPE), seminal vesicle invasion (SVI), and positive surgical margin (SM+) 1388 RPs.Each at RP was independently graded, staged, volumetrically assessed. TNs least 80% their volume occupying either anterior or posterior part were categorized accordingly included our study, while all...
Background Condyloma acuminatum is a squamous epithelial lesion which uncommonly involves the urinary tract. In this location, non-invasive papillary urothelial carcinoma constitutes one of main differential diagnoses with significant prognostic and therapeutic implications. To date, no ancillary immunohistochemical stain has been described to differentiate these two entities. We assess utility cytokeratin 5/6 (CK5/6) GATA-3 immunohistochemistry in distinguishing condyloma from carcinoma....
Introduction. Small cell carcinoma can arise from various sites. Herein, we analyze the ability of 2 thyroid transcription factor-1 (TTF-1) antibodies (SPT24 and 8G7G3/1) to separate pulmonary nonpulmonary small carcinoma. Materials Methods. We analyzed 26 83 carcinomas, 14 Merkel carcinomas. Each tumor was stained with SPT24 8G7G3/1. Extent nuclear staining scored as diffuse (>50%), focal (11%-50%), rare (1%-10%), or negative (<1%). Results. All carcinomas were positive for Four (29%)...
Context.— Retraction artifact, paradoxic maturation/differentiation, desmoplasia, and complex irregular growth are morphologic criteria of invasion in urothelial carcinoma. Objective.— To describe changes mimicking noninvasive papillary carcinoma (NPUC). Design.— We reviewed 159 consecutive in-house patients with NPUC for either the presence pseudoinvasion (irregular nests within dense hyalinized stroma absence other invasion) or precursor findings (stromal hyalinization not yet associated...
Critical airway stenosis presents a challenge for surgeons and anesthesiologists alike in securing reliable adequate ventilation. The use of veno-venous (VV) extra-corporeal membrane oxygenation (ECMO) has been described as strategy to provide gas exchange such instances. We present case young female with complex paratracheal mass significantly compressing the trachea whom planned intra-operative VV ECMO was instituted allow safe oro-tracheal intubation double lumen endotracheal tube lung...