A5040422270- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- HER2/EGFR in Cancer Research
- Cervical Cancer and HPV Research
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Reproductive Biology and Fertility
- Intraperitoneal and Appendiceal Malignancies
- Gynecological conditions and treatments
- Intestinal and Peritoneal Adhesions
- Anorectal Disease Treatments and Outcomes
- PI3K/AKT/mTOR signaling in cancer
- PARP inhibition in cancer therapy
- Minimally Invasive Surgical Techniques
- Appendicitis Diagnosis and Management
- Monoclonal and Polyclonal Antibodies Research
- Cardiac, Anesthesia and Surgical Outcomes
- Diverticular Disease and Complications
- Immunotherapy and Immune Responses
- Menopause: Health Impacts and Treatments
- Nausea and vomiting management
- Estrogen and related hormone effects
- Ethics in medical practice
Campus Bio Medico University Hospital
2013-2025
Università Campus Bio-Medico
2016-2025
University of Ferrara
2024
Sapienza University of Rome
2013-2015
Significance Some cancers, termed carcinosarcomas (CSs), have mixed cell types, with either epithelial or mesenchymal features. Sequencing the genomes of uterine and ovarian CSs demonstrated that these different types derive from a common precursor has many mutations typical cancers. In addition, we find tumors significant burden point amplification histone genes, suggesting potential role in sarcomatous transformation. Consistent this finding, expression specific gene carcinoma cells...
Human epididymis protein 4 (HE4) was recently approved by the Food and Drug Administration to monitor recurrence or progressive disease in epithelial ovarian cancer conjunction with CA125. This is first prospective controlled study literature evaluating sensitivity specificity of HE4 CA125 detecting recurrent cancer. Serum samples were obtained 24 h before surgery from 34 patients suspicious benign adnexal pathology, operated November 2010 2011 at University Campus Bio-Medico Rome. The...
High-grade neuroendocrine cervical cancers (NETc) are exceedingly rare, highly aggressive tumors. We analyzed 64 NETc tumor samples by whole-exome sequencing (WES). Human papillomavirus DNA was detected in 65.6% (42/64) of the Recurrent mutations were identified PIK3CA, KMT2D/MLL2, K-RAS, ARID1A, NOTCH2, and RPL10. The top mutated genes included RB1, PTEN, KMT2D / MLL2, WDFY3, a gene not yet implicated NETc. Somatic CNV analysis two copy number gains (3q27.1 19q13.12) five losses...
Actually, in literature there are not valid tools able to predict the chemotherapy response during first-line ovarian cancer treatment. CA125 and human epididymis protein 4 (HE4) levels of consecutive single-institution patients with epithelial (EOC) were measured until 6 months follow-up. First, divided into two groups according a temporal criterion: treated 2009 (group A: training group) 2010 B: verification group). At sixth follow-up, sub-classified, within both groups, as platinum...
Aims The aim of this study was to evaluate long-term quality life and urinary sexual function in cervical cancer survivors previously treated with radical hysterectomy (RH) type C2/type III. Methods All patients who presented at Campus Bio-Medico Rome for RH III were considered eligible retrospective protocol. We included exclusively complete response primary treatment least 36 months follow up. Included subjects interviewed the European Organization Research Treatment Cancer QLQ-CX24...
Total abdominal hysterectomy is a procedure associated with moderate to severe postoperative pain. Regional anesthesia techniques, such as fascial plane blocks, have shown promise in improving pain control. While continuous wound infusion recommended for cesarean section, it not open hysterectomy. Our aim compare surgically placed catheter the transverse abdominis block. A single-center prospective randomized controlled trial was conducted Italy from January July 2023. Patients undergoing...
Background: Serum biomarkers such as Carcinoma Antigen 125 (CA125) and Human Epididymis Protein 4 (HE4) are widely used in the diagnosis prognosis of gynecological malignancies. CA125 HE4 represent essential tools improving early detection, risk stratification, therapeutic decision-making for However, their role identifying uterine sarcomas remains debated. This systematic review case series aims to examine diagnostic prognostic significance sarcomas. Methods: A was performed on studies...
Background: Pelvic organ prolapse (POP) significantly impacts women’s quality of life, especially in postmenopausal patients. Although laparoscopic sacrocolpopexy (LSC) is the gold standard for advanced apical prolapse, its complexity and risk complications have led to alternative approaches like lateral suspension (LLS), a minimally invasive technique with promising results. Methods: A comprehensive search using PubMed databases was performed. The conducted from June 2024 September 2024....
The aim of this study was to evaluate for the first time in literature role HE4, at primary diagnosis, compared CA125 as an indicator endometrial cancer (EC) recurrence. Our is a retrospective analysis 252 EC patients treated, between January 2009 and July 2013, Division Gynaecologic Oncology Campus Bio-Medico University Rome. Thirty-seven experienced Median follow-up 38 months. HE4 levels were analyzed during either after histological or radiological confirmation recurrent disease last...
The life of a family caregiver changes in many ways when cancer is diagnosed. Changes regard also financial costs. To the authors' knowledge, little work has been done to estimate costs associated with caregiving for patients. aim present study evaluate first time literature economic among caregivers advanced ovarian during first-line treatment an Italian survey.Between January 2009 and June 2014, primary patients (N = 172) were recruited from Division Gynecologic Oncology University Campus...
HER2/neu gene amplification and PIK3CA driver mutations are common in uterine serous carcinoma (USC) may represent ideal therapeutic targets against this aggressive variant of endometrial cancer. We examined the sensitivity to neratinib, taselisib, combination two compounds vitro vivo experiments using PIK3CA-mutated wild-type HER2/neu-amplified USC cell lines. Cell viability cell-cycle distribution were assessed flow-cytometry assays. Downstream signaling was by immunoblotting. Preclinical...