A5076021844- Traditional Chinese Medicine Studies
- GABA and Rice Research
- Traditional Chinese Medicine Analysis
- Rice Cultivation and Yield Improvement
- Gut microbiota and health
- Curcumin's Biomedical Applications
- Flavonoids in Medical Research
- Genetic Mapping and Diversity in Plants and Animals
- Dietary Effects on Health
- Natural Antidiabetic Agents Studies
- Pesticide Residue Analysis and Safety
- Microbial Metabolism and Applications
- Prostate Cancer Diagnosis and Treatment
- Occupational and environmental lung diseases
- Click Chemistry and Applications
- Natural product bioactivities and synthesis
- Genetic Associations and Epidemiology
- Chemical Synthesis and Analysis
- Cognitive Abilities and Testing
- Soybean genetics and cultivation
- Genomics, phytochemicals, and oxidative stress
- Metabolomics and Mass Spectrometry Studies
- Urinary Tract Infections Management
- Birth, Development, and Health
- Pleural and Pulmonary Diseases
Sichuan Academy of Traditional Chinese Medicine
2020-2025
Chengdu University
2024
Xishuangbanna Tropical Botanical Garden
2024
Shanghai Normal University
2022
University of Macau
2021
Huazhong Agricultural University
2011
Chinese Academy of Medical Sciences & Peking Union Medical College
2010
In recent decades, natural compounds derived from herbal medicine or dietary sources have played important roles in prevention and treatment of various diseases attracted more attention. Curcumin, extracted the
Abstract Peptide-drug conjugates (PDCs) have emerged as a promising strategy in cancer therapy, offering improved therapeutic efficacy and reduced toxicity. Compared to antibody-drug (ADCs) small molecule-drug (SMDCs), PDCs possess distinct advantages, such lower immunogenicity, tumor penetration, simpler synthesis. This review discusses the latest advancements PDC design, including novel peptide targeting mechanisms, linker selection, formulation improvements for increased stability....
The main objective of this study was to investigate the alterations in gut microbiota (GM) pulmonary fibrosis (PF) mice induced by bleomycin (BLM) with its underlying mechanisms. BLM docked targets TGF-β/SMAD and caspase-3 pathways using molecular docking technique. HE staining Masson were applied observe histopathological changes tissues. Detection apoptotic signals conducted flow cytometry TUNEL staining. mRNA expression involved signaling lungs determined qPCR. Immunohistochemistry (IHC)...
Numerous studies have supported that nonalcoholic fatty liver disease (NAFLD) is highly associated with gut microbiota dysbiosis. Ling-Gui-Zhu-Gan decoction (LG) has been clinically used to treat NAFLD, but the underlying mechanism remains unknown. This study investigated therapeutic effect and mechanisms of LG in mice NAFLD induced by a high-fat diet (HD). An HD-induced model was established evaluate efficacy followed biochemical histopathological analysis. Metagenomics, metabolomics,...
The NF-κB signaling pathway is overactivated in tumor cells, and the activation of releases a large number inflammatory factors, which enhance immunosuppression promote metastasis. cytochrome P450 (CYP450) system consists important metabolic enzymes present different tissues progressive tumors, may lead to changes pharmacological action drugs diseases such as tumors. In this study, anticancer effect tetrahydrocurcumin (THC), an active metabolite curcumin, on breast cancer cells underlying...
Background Xiaojin Pill (XJP) is a traditional Chinese medicine prescribed for treating benign prostatic hyperplasia (BPH). It has been proven to have multiple effects, such as regulating sex hormone levels, exhibiting anti-tumor, anti-inflammatory, analgesic, and anti-platelet aggregation properties, improving immunity. However, the material basis of XJP's therapeutic effect on BPH its metabolic process in vivo remains be clarified. At same time, many microorganisms that exist urogenital...
Rice is one of the most important food crops in Asia. Genetic analyses complex traits and molecular breeding studies rice greatly rely on construction various genetic populations. Chromosome segment substitution lines (CSSLs) serve as a powerful population for quantitative trait locus (QTL) mapping rice. Moreover, CSSLs containing target genomic regions can be used improved varieties breeding. In this study, we developed set consisting 117 derived from recipient 'Huanghuazhan' (HHZ) donor...
The aim of this paper was to observe the anti-inflammatory action and mechanism Lonicerae Japonicae Flos extract in xylene-induced ear swelling experiment lipopolysaccharide(LPS)-induced RAW264.7 cell inflammatory model. In vivo, mouse auricle model used detect degree inhibition rate extract; pathological changes mice were observed by hematoxylin eosin(HE) staining. vitro, induced LPS, where cytotoxic effects on cells detected CCK-8 method; Griess method effect nitric oxide(NO) production,...
In this research, a very practical QuEChERS-GC-MS/MS analytical approach for 74 pesticide residues in herb based on retention index was established. This novel has two important technical advantages. One advantage is to quickly screen compounds herbs without having use large number of standard substances at the beginning experiment. The other assist identifying target compound accurately. A total kinds pesticides were prescreened all chuanxiong rhizoma samples. results showed that three...
WRKY transcription factor family plays an important role in plant growth and development, secondary metabolite synthesis, biotic abiotic stress responses. The present study performed full-length transcriptome sequencing of Polygonatum cyrtonema by virtue the PacBio SMRT high-throughput platform, identified bioinformatics methods, analyzed physicochemical properties, subcellular localization, phylogeny, conserved motifs. results showed that 30.69 Gb nucleotide bases 89 564 transcripts were...
Nyctinastic leaf movement of Fabaceae is driven by the tiny motor organ pulvinus located at base or leaflet. Despite increased understanding essential role ELP1 orthologs in determining identity, key regulatory components and molecular mechanisms underlying this remain largely unclear. Here, we used WT equivalent tissue elp1 mutant to carry out transcriptome proteome experiments, omics data indicated that there are multiple cell biological processes altered gene expression protein abundance...
The development of traditional Chinese medicine(TCM) preparations as an incubator for new drugs in medical institutions has flourished, while evaluation index system remains to be established comprehensively assessing the value these prescriptions. This study item pool through literature research, employed Delphi method determine content indexes, and adopted superiority chart weight each index. Two-level TCM was established, which included 7 first-level items 36 se-cond-level items,...
"Huajiao" is dried ripe fruit peel of Zanthoxylum bungeanum or Z. schinifolium, konwn as geoherbs, especially the "Dahongpao" cultivated in Hanyuan, Maoxian and Jiulong Sichuan province. However, genetic basis Dao-di virtually unknown. The transcriptome leaf from Sichuan(Hanyuan, Jiulong, Lixian, Maoxian), Gansu(Wudu) province Shaanxi(Fengxian) was sequenced. Trinity de novo assembling resulted a total 177 616 unigenes. Through KEGG, NR, SwissProt, Trembl, KOG/COG, GO,...
Dao-di herbs is one of the characteristics traditional Chinese medicine different from other ethnic medicine. Sichuan province rich in varieties and resources herbs, its development scale benefits are not obvious recent decades due to lag standards behind times objective needs. From point view whole process industrial chain, significance standardization system for quality assurance, healthy industry, industry presented this paper. At present, has made every effort promote construction...
Guided by the basic theory of traditional Chinese medicine and using modern scientific methods, Dao-di herbs pharmacology studies nature, performance, interaction with body its clinical application.It is a bridge between research application herbs. It can objectively describe law efficacy herbs, scientifically explain mechanism explore establish standards methods based on biological effect efficacy, provide basis for special properties, value herbs.Furthermore, we put forward new idea...
To establish a fast sensitive, reproducible LC-MS/MS method to study pharmacokinetic properties of THC, and compare relative bioavailability THC its solid dispersion in mice. 200 mice were divided randomly into two groups, administered orally with THC-solid after fasting (calculate on THC:400 mg x kg(-1)), used HPLC-MS/MS determine the concentration each period at following times: baseline ( predose ), 15, 30, 45 min, 1, 1.5, 2, 3, 4, 6, 24 h dosing. Calculating parameters according C-t...
Yi Yin, a famous medical scientist and culinary master in the late Xia Dynasty early Shang Dynasty, developed Chinese medicinal liquids prescriptions emerged after that. have attracted much attention because of their unique advantages treatment chronic multifactorial diseases, representing an important direction drug discovery future. Yiyin decoction theory is superior form personalized combined medication with advanced consciousness. It different from not only magic bullet single component...