A5090277750- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Diagnosis and treatment of tuberculosis
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- PI3K/AKT/mTOR signaling in cancer
- Pharmaceutical studies and practices
- RNA Interference and Gene Delivery
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- RNA Research and Splicing
- RNA regulation and disease
- Esophageal and GI Pathology
- Animal Nutrition and Physiology
- TGF-β signaling in diseases
- Microscopic Colitis
- Gallbladder and Bile Duct Disorders
- Livestock and Poultry Management
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Eosinophilic Esophagitis
University of California, San Francisco
2023
Dana-Farber Cancer Institute
2019-2021
Molecular Oncology (United States)
2020-2021
Harvard University
2019-2021
Gazi University
2013-2020
NYU Langone Health
2019
Dartmouth–Hitchcock Medical Center
2019
University of Alberta
2019
Diffuse gastric cancer (DGC) is a lethal malignancy lacking effective systemic therapy. Among the most provocative recent results in DGC has been that of highly recurrent missense mutations GTPase RHOA. The function these remained unresolved. We demonstrate RHOAY42C, common RHOA mutation DGC, gain-of-function oncogenic mutant, and expression RHOAY42C with inactivation canonical tumor suppressor Cdh1 induces metastatic mouse model. Biochemically, exhibits impaired GTP hydrolysis enhances...
Background and AimsBarrett's esophagus (BE) is the precursor to esophageal adenocarcinoma. A major challenge identifying small group with BE who will progress advanced disease from many not. Assessment of p53 status has promise as a predictive biomarker, but analytic limitations lack validation have precluded its use. The aim this study was develop robust criteria for grading abnormal immunohistochemical (IHC) expression test utility biomarker progression in BE.MethodsCriteria IHC were...
Aims There is limited information regarding the clinicopathological features of low‐grade tubuloglandular (LGTGA) and mucinous (MAC) adenocarcinomas occurring in inflammatory bowel disease (IBD), especially with regard to their precursor lesions. Methods results Forty‐six IBD colectomy specimens LGTGA ( n = 17) or MAC 29) adjacent lesions were analysed. As controls, 12 well‐ moderately differentiated adenocarcinoma that lacked any mucinous, signet ring cell, serrated also Compared MACs...
Background Immune checkpoint inhibitors have revolutionized cancer treatment, but the benefits in refractory patients with esophageal been modest. Predictors of response as well new targets for novel therapeutic combinations are needed. In this phase 2 clinical trial, we tested single-agent pembrolizumab advanced cancer, who received at least one prior line therapy. Methods Pembrolizumab 200 mg every 3 weeks was 49 cancer: 39 adenocarcinoma and 10 squamous cell carcinoma. Major endpoints...
In Barrett's oesophagus (BE), after radiofrequency ablation (RFA), the can be repopulated with a stratified 'neosquamous epithelium' (NeoSE). While histologically normal, origin and clonal make-up of this NeoSE is unknown. An increased understanding important as some studies suggest that biologically abnormal. The aim study was to determine whether there were major differences in mutational landscape or size versus normal squamous epithelium shares any pathogenic mutations BE. 10 patients...
Abstract Introduction/Objective The development of new synthetic insulin analogues over the past few decades has significantly impacted management hypoglycemia. However, accurately measuring these presents challenges due to variable cross-reactivity with many assays. Failure consider may lead misdiagnosis exogenous administration. Methods/Case Report A 13-year-old female a history type 1 DM was presented an outside hospital emergency department symptoms indicative Multiple child protective...
Objective: Cholecystectomy materials are frequently encountered in routine practice.The aim of this study was to determine the true frequency gallbladder lesions, diagnostic consistency, and standardization reports after macroscopic sampling microscopic evaluation based on previously defined criteria.Material Method: 14 institutions participated within Hepato-Pancreato-Biliary Pathology Study Group.Routinely examined cholecystectomies last year were included these institutions.Additional...
ABSTRACT Barrett’s esophagus is the precursor to esophageal adenocarcinomas, which are deadly cancers with a rapidly rising incidence. A major challenge identifying small group who will progress advanced disease from many not. Assessment of p53 status has promise as predictive biomarker, but analytic limitations and lack validation in large, definitive studies have precluded its use. In this study, criteria for abnormal immunohistochemical expression were developed non-dysplastic biopsies...
<div>Abstract<p>Diffuse gastric cancer (DGC) is a lethal malignancy lacking effective systemic therapy. Among the most provocative recent results in DGC has been that of highly recurrent missense mutations GTPase RHOA. The function these remained unresolved. We demonstrate RHOA<sup>Y42C</sup>, common RHOA mutation DGC, gain-of-function oncogenic mutant, and expression RHOA<sup>Y42C</sup> with inactivation canonical tumor suppressor <i>Cdh1</i>...
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<p>Supplementary Video S1</p>
<p>Supplementary Methods</p>
<p>Supplementary Figures and Legends</p>