A5101503350- Helicobacter pylori-related gastroenterology studies
- Phytochemicals and Antioxidant Activities
- Food Quality and Safety Studies
- Vector-Borne Animal Diseases
- Natural Antidiabetic Agents Studies
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Pharmacology and Obesity Treatment
- Pharmacological Effects of Natural Compounds
- Gastroesophageal reflux and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Shoulder and Clavicle Injuries
- Tannin, Tannase and Anticancer Activities
- Botulinum Toxin and Related Neurological Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Virus-based gene therapy research
- Botanical Research and Applications
- Antioxidants, Aging, Portulaca oleracea
- Bone fractures and treatments
- Advanced Nanomaterials in Catalysis
- Adipose Tissue and Metabolism
- Hereditary Neurological Disorders
- Moyamoya disease diagnosis and treatment
- Virology and Viral Diseases
Animal and Plant Quarantine Agency
2017-2024
Bucheon University
2022
Soonchunhyang University
2022
Daegu Haany University
2015-2017
Government of the Republic of Korea
2016
Pusan National University
2014-2015
Sunlin University
2003
Pancreatic lipase is the enzyme responsible for digestion and absorption of triglycerides, being its inhibition one widest studied methods used to determine potential activity natural products inhibit dietary fat absorption. Decrease energy intake from through this may be an excellent strategy prevent treat obesity. The inhibitory on pancreatic Diospyros kaki fruit Citrus unshiu peel mixture extract (PCM) was evaluated in vitro antiobesity effects were based serum lipid parameters analysis...
The purpose of this study was to investigate the antioxidant and anti‐inflammatory effects combined extract Rhei rhizoma Coptidis (RC‐mix) in experimental model acute reflux esophagitis. activity assessed by vitro 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) assays. RC‐mix given at 100, 200, 400 mg/kg body weight 2 h prior induction esophagitis (RE). After 5 h, treated rats were compared with those normal control rats. representative...
We have identified the effects of oligonol, a low-molecular polyphenol derived from lychee fruit, on diabetes-induced pancreatic damage via oxidative stress. Oligonol was orally administered at 10 or 20 mg (kg d)(-1) for days to streptozotocin (STZ)-induced diabetic rats, and we assessed changes in serum glucose insulin levels, as well those body weight food water consumption. In addition, analyses weight, content, reactive oxygen species (ROS) level, western blots nicotinamide adenine...
Rhei Rhizoma has been widely used as a traditional herbal medicine to treat various inflammatory diseases. The present study was conducted evaluate its anti-inflammatory activity against experimental reflux-induced esophagitis (RE) in SD rats.Rhei administered at 125 or 250 mg/kg body weight per day for 7 days prior the induction of reflux esophagitis, and effect compared with RE control normal administration markedly ameliorated mucosal damage on histological evaluation. elevated reactive...
The present study was conducted to examine whether magnesium lithospermate B (MLB) extracted from Salviae miltiorrhizae radix renoprotective in pathways related age-related oxidative stress aged rats. Magnesium orally administered at a dose of 2- or 8-mg/kg body weight for 16 consecutive days, and the effects were compared with those vehicle old young administration rats ameliorated renal through reduction reactive oxygen species. exhibited dysregulation expression proteins inflammation...
Nonalcoholic fatty liver disease (NAFLD) has been a major cause of chronic over recent decades and increasing worldwide in parallel with the remarkable growth obesity. In present study, we investigate ameliorative effects PCM, combination Diospyros kaki fruit Citrus unshiu peel mixture, on high-fat diet- (HFD-) induced NAFLD clarify potential mechanisms. PCM HFD-fed mice was orally administered at dose 50 or 100 mg/kg subsequently for 2 months. Thereafter, lipid metabolism parameters fat...
Persicarin is one of the major components Oenanthe javanica (water dropwort). The present study was aimed to evaluate role persicarin in hepatic tissue streptozotocin-induced type 1 diabetic mice. Diabetes induced by single intra-peritoneal injection streptozotocin (120 mg/kg body weight) and then oral administration at a dose 2.5 5 weight for 10 days. Serum glucose levels were increased control mice, while treatment groups markedly reduced. Also, ALT AST serum improved persicarin. In our...
Foot-and-mouth disease (FMD) vaccines are currently the most powerful protective and preventive measures used to control FMD. In this study, chimeric vaccine strain containing antigenic epitopes from FMD virus serotype A, which belongs ASIA topotype, was produced evaluated. The strains contain sea-97/G1 (VP4, VP2, VP3) A22 Iraq (VP1) or G-VII for use in Asia. 50% dose determined mice. Vaccinated mice were challenged with three different type A viruses (Sea-97/G1, Sea-97/G2, clade) seven days...
BACKGROUND/OBJECTIVES: Colitis is a serious health problem, and chronic obesity associated with the progression of colitis.The aim this study was to determine effects natural raw meal (NRM) on high-fat diet (HFD, 45%) dextran sulfate sodium (DSS, 2% w/v)-induced colitis in C57BL/6J mice.MATERIALS/METHODS: Body weight, colon length, weight-to-length ratio, were measured directly.Serum levels obesity-related biomarkers, triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL),...
To analyze the relationship between homologous and heterologous serological titers of immunized pigs their protection statuses against FMD virus challenges, in present study, correlation neutralization at 21 28 dpv challenge with was analyzed using data sets comprising five different combinations or experiments vaccinated type O (n = 96), A 69), Asia 1 74). As a result, were divided into three groups (21D-1, 21D-2, 21D-3) 21-dpv model two (28D-1 28D-2) 28-dpv model. Each response curve 21D-1...
Oligonol, a polyphenol derived from lychee fruit, is produced by an oligomerization process that converts high-molecular-weight polymers into low-molecular-weight oligomers. Evidence suggests oligonol exerts its beneficial effects based on antioxidant and anti-inflammatory properties. This study was the first to investigate antioxidative of gastroesophageal inflammatory models: surgically induced acute reflux esophagitis (RE) gastric ulcer (GU) HCl/ethanol. In in vitro study,...
Outbreaks caused by foot-and-mouth disease (FMD) A/ASIA/G-VII lineage viruses have often occurred in Middle Eastern and Southeast Asian countries since 2015. Because are reported to distinct antigenic relatedness with available commercial FMD vaccine strains, it is necessary investigate whether inoculation vaccines used Korea could confer cross-protection against viruses. In the present study, we conducted two vaccination challenge trials evaluate efficacy of three (O/Manisa + O/3039 A/Iraq,...
Oligonol is a low-molecular-weight polyphenol derived from lychee fruit. This study was conducted to examine whether oligonol has an ameliorative effect on diabetes-induced pancreatic damage via oxidative stress-induced inflammation. orally administered at 10 or 20 mg/kg body weight/day for days streptozotocin-induced diabetic rats, and changes in serum glucose, C-peptide, insulin, reactive oxygen species (ROS), thiobarbituric acid-reactive substance (TBARS) levels as well weight food water...
Purpose: The aim of this study is to determine the antiadipogenesis effect Do-Hong-Sa-Mul-Tang (DHSMT) in vitro Methods: We adopted Oil red O staining that observed formation fat droplets anti-adipogenesis effects DHSMT. And triglyceride (TG) production, leptin level and protein expressions peroxisome proliferatoractivated receptor gamma (PPAR ), CCAAT/enhancer binding proteins alpha (C/EBP ) 3T3-L1 adipocytes. Results: TG was suppressed about 3 fold as compare differentiation group. Leptin...
The aim of this study was to investigate the anti‐inflammatory effect JUVO (J; an American style saengshik) on high fat diet(HFD, 45%) and dextran sulfate sodium (DSS, 2% wt/wt) induced ulcerative colitis (UC) in C57BL/6J mice. Saengshik (S) used as a positive control. Body weight changes, colon length ratio length/weight were evaluate preventive effects Histological changes observed by hematoxylin eosin (H&E) staining. significantly suppressed HFD/DSS‐induced body losses shortening...
Purpose: Young persimmon fruit (YPF) has recently been reported to have an inhibitory effect on the lipid metabolism. So, this study examined whether YPF a anti-obesity lipidmetabolism and adipocyte differentiation through AMP-activated protein kinase (AMPK) pathways in obese mice. Methods: (100 or 200mg/kg body weight/day, p.o.) was administered every day for 3 weeks male 12-weeks-old (db/db) mice, its compared with nonobese (m/m) vehicle-treated Results: The administration of caused...
The present study was to investigate the effect of American style natural raw meal (NRM-A, JUVO®) which contains high levels freeze-dried brown rice and berries on Azoxymethane (AOM, 10 mg/kg) Dextran Sulfate Sodium (DSS, 2%)-induced colon cancer in C57BL/6J mice. Freeze-dried vegetables enriched Korean (NRM-K), anti-diabetic NRM (NRM-DM) were used as positive controls. Colon length, ratio weight tumor numbers tissue employed evaluate preventive effects NRM-A Histological changes observed by...