A5066242584- Reproductive tract infections research
- Reproductive System and Pregnancy
- Cystic Fibrosis Research Advances
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Immune responses and vaccinations
- Spondyloarthritis Studies and Treatments
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Blood groups and transfusion
- Pediatric health and respiratory diseases
- Medical Imaging and Pathology Studies
- Bacterial Infections and Vaccines
- Immune cells in cancer
- Respiratory viral infections research
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- Cervical Cancer and HPV Research
- Immune Cell Function and Interaction
- Advanced X-ray and CT Imaging
- Autoimmune and Inflammatory Disorders Research
Rigshospitalet
2022-2024
Copenhagen University Hospital
2022-2024
Aalborg University
2018-2020
Aalborg University Hospital
2015
The aetiologies and pathogeneses of the joint diseases rheumatoid arthritis (RA) spondyloarthritis (SpA) are still not fully elucidated. To increase our understanding molecular pathogenesis, we analysed protein composition synovial fluid (SF) from patients.Fifty-six samples (RA, n = 32; SpA, 24) were digested with trypsin, resulting peptides separated by liquid chromatography tandem mass spectrometry. Additionally, concentration cell-free DNA (cfDNA) in was measured, plasma C-reactive (CRP)...
9561 Background: Personalized vaccines, targeting mutation-derived neoantigens (neoAg), represent a promising frontier in cancer immunotherapy. Here, we characterize the vaccine-induced immune response seven melanoma patients treated with AI-generated personalized vaccine, EVX-01, ongoing single arm multicenter trial (NCT05309421). Data from an additional five will be available at time of presentation. Methods: Tumor-specific neoAgs were identified and selected using proprietary vaccine...
The human respiratory tract pathogen Chlamydia pneumoniae , which causes mild to severe infections, has been associated with the development of chronic inflammatory diseases. To understand biology C. several studies have investigated interaction between and professional phagocytes. However, these conducted under nonopsonizing conditions, making role opsonization in infections elusive.
<h3>Background</h3> EVX-02, a personalized neoantigen DNA vaccine, was assessed in combination with an anti-PD-1 therapy (nivolumab) patients fully resected melanoma and at high risk of disease recurrence. The EVX-02 vaccines were designed by Evaxion's proprietary AI platform, PIONEER, based on the unique mutational profile each tumor patient's HLA type. PIONEER identifies cancer-specific mutations analyzing differences sequences healthy sample. non-synonymous subset these is then further...
Pharmacodynamic assessment of T-cell-based cancer immunotherapies often focus on detecting rare circulating T-cell populations. The therapy-induced immune cells in blood-derived clinical samples are present very low frequencies and with the currently available analytical assays, amplification interest prior to analysis is required. Current approaches aiming enrich antigen-specific T from human Peripheral Blood Mononuclear Cells (PBMCs) depend vitro culturing presence their cognate peptides...
Objectives Lung disease progression in people with cystic fibrosis (pwCF) varies from one individual to another. Different immunological characteristics have been suggested explain this variation, and we hypothesised that lung capacity may be associated the innate immune response pwCF. In an exploratory study, aimed investigate potential links between function pwCF using standardised assay TruCulture. Methods a single-centre study combined cross-sectional longitudinal data before after...
Comparing imaging examinations with those previously obtained is considered mandatory in guidelines. To our knowledge, no studies are available on neither the influence, nor sequence, of prior and reports diagnostic accuracy using biopsy as reference standard. Such data important to minimize errors improve preparation The aim study was provide such data.A retrospective cohort 216 consecutive skeletal biopsies from patients at least 2 different modalities (X-ray, CT MRI) performed within 6...
<h3>Background</h3> Neoantigens derived from cancer-specific mutations are currently being utilized as targets in personalized cancer vaccine treatments. Here, we characterize the neoantigen-specific reactivity and clinical response five patients treated with an AI generated therapeutic (EVX-01)<sup>1</sup> ongoing melanoma single-arm open-label multi-center phase II trial (NCT05309421). <h3>Methods</h3> The proprietary PIONEER<sup>TM</sup> platform for identification selection of...
Abstract Polymicrobial airway infections and detrimental inflammation characterize patients with cystic fibrosis (CF), a disease heterogeneous clinical outcomes. How the overall immune response is affected in CF, its relationships lung microbiome, source of heterogeneity are unclear. Our work identifies specific CF profile characterized by widespread hyperactivation, enrichment CD35 + /CD49d neutrophils, reduction dendritic cells. Further, our data indicate signs dysregulation due to...