A5008159640- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- Vector-Borne Animal Diseases
- Phytochemicals and Antioxidant Activities
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Fire effects on ecosystems
- Vector-borne infectious diseases
- COVID-19 epidemiological studies
- Bioenergy crop production and management
- Legionella and Acanthamoeba research
- Biochemical and biochemical processes
- Animal Disease Management and Epidemiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Natural Products and Biological Research
- GABA and Rice Research
- Viral Infections and Outbreaks Research
- Reproductive Biology and Fertility
- Veterinary Equine Medical Research
- Exercise and Physiological Responses
- Food composition and properties
- Neuroinflammation and Neurodegeneration Mechanisms
- Morinda citrifolia extract uses
Center for Grain and Animal Health Research
2017-2024
Agricultural Research Service
2017-2023
United States Department of Agriculture
2018-2023
Cornell University
2007-2022
New York State College of Veterinary Medicine
2010-2022
Sorghum is an important cereal with diverse phenolic compounds that have potential health promoting benefits. The current study comparatively characterized the contents of two novel black-seeded sorghum lines (SC84 and PI570481) using different extraction systems (water, ethanol their acidified counterparts) evaluated antioxidant anti-inflammatory activities. Phenolic compositions were determined by spectrophotometric assays HPLC analysis. Antioxidant activities assessed radical scavenging...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged that the causative agent of disease 2019 (COVID-19) pandemic. COVID-19 in humans characterized by wide range symptoms from asymptomatic to mild or severe illness including death. SARS-CoV-2 highly contagious and transmitted via oral–nasal route through droplets aerosols, contact with contaminated fomites. House flies are known transmit bacterial, parasitic viral diseases animals as...
As diet is one of the major controllable factors in cancer development, potentially chemopreventive foods are significant interest to public health. One such food sorghum (Sorghum bicolor), a cereal grain that contains varying concentrations polyphenols. In panel 15 germplasm, we identified strains with higher polyphenol content than previously reported for this grain. Bran extracts from germplasm highest and lowest were then tested against HepG2 Caco2 cells assess effects on cell viability,...
Split immunological tolerance refers to states in which an individual is capable of mounting certain types immune responses a particular antigenic challenge, but tolerant the same antigen other compartments system. This concept applicable relationship between mother and fetus, particularly relevant equine pregnancy. In pregnant mares, antibody paternal foreign Major Histocompatibility Complex class I antigens are robust, while anti-paternal cytotoxic T cell diminished compared those mounted...
Certain foods such as turmeric and green tea have been extensively studied for anticancer properties, while high polyphenol sorghum has not received the same attention. Some bioactive compounds in Sorghum bicolor with activity identified, indicating further need research screening methods of varieties. This study was aimed at improving extraction by using food-grade solvents ethanol citric acid. We used three varieties (GT) a control. The were screened anti-proliferative properties HepG2...
Human colon cancer is the third leading cause of mortality in United States and worldwide. Chemoprevention using diet widely accepted as a promising approach for management. Numerous population studies indicate negative correlation between incidence consumption whole grains with high content bioactive phenolic compounds. In current study, we evaluated anticancer properties sorghum bran extract prepared 70% ethanol 5% citric acid solvent at room temperature. A significant dose-dependent...
Rift Valley fever virus, a zoonotic arbovirus, poses major health threats to livestock and humans if introduced into the United States. White-tailed deer, which are abundant throughout country, might be sentinel animals for arboviruses. We determined susceptibility of these deer this virus provide evidence potentially epidemiologic role.
Japanese encephalitis virus (JEV) is a zoonotic mosquito-borne flavivirus endemic in the Asia-Pacific region. Maintenance of JEV nature involves enzootic transmission by competent Culex mosquitoes among susceptible avian and swine species. Historically, has been regarded as one most important arthropod-borne viruses Southeast Asia. Oronasal shedding from infected amplification hosts was not recognized until recent discovery vector-free domestic pigs. In this study, oral characterized pigs...
Japanese encephalitis (JE) is a zoonotic, emerging disease transmitted by mosquito vectors infected with the virus (JEV). Its potential for emergence into susceptible regions high, including in United States (US), and reason of economic concern among agricultural community, to public health due high morbidity mortality rates humans. While exploring complexities interactions involved viral transmission, we proposed new outlook on role vectors, hosts environment under changing conditions. For...
Abstract Rift Valley fever virus (RVFV) (Bunyavirales: Phlebovirus) is a prominent vector-borne zoonotic disease threat to global agriculture and public health. Risks of introduction into nonendemic regions are tied changing climate regimes other dynamic environmental factors that becoming more prevalent, as well evolutionary human/animal movement. Endemic the African continent, RVFV has caused large epizootics at decadal scale since early 20th century but spread Arabian Peninsula shows...
Colon cancer (CC) is considered a high-risk in developed countries. Its etiology correlated with high consumption of red meat and low plant-based foods, including whole grains. Sorghum bran rich polyphenols. This study aimed to determine whether different high-phenolic sorghum brans suppress tumor formation genetic CC rodent model elucidate mechanisms. Tissue culture experiments used colorectal cell lines SW480, HCT-116 Caco-2 measured protein expression, activity. The animal this was APC...
Abstract SARS-CoV-2 is a recently emerged, highly contagious virus and the cause of current COVID-19 pandemic. It zoonotic virus, although its animal origin not clear yet. Person-to-person transmission occurs by inhalation infected droplets aerosols, or direct contact with contaminated fomites. Arthropods transmit numerous viral, parasitic, bacterial diseases; however, potential role arthropods in fully understood. Thus far, few studies have demonstrated that replication supported cells from...
Epizootic hemorrhagic disease virus (EHDV) is an arthropod-transmitted RNA and the causative agent of epizootic (EHD) in wild domestic ruminants. In North America, white-tailed deer (WTD) experience highest EHD-related morbidity mortality, although clinical reported cattle during severe epizootics. No commercially licensed EHDV vaccine available America. The objective this study was to develop evaluate a subunit candidate control EHD WTD. Recombinant VP2 (rVP2) outer capsid proteins...
Problem Pregnant mares demonstrate a reduction in cytotoxic T lymphocyte ( CTL ) reactivity against cells from the breeding stallion. We investigated whether this effect is limited to activity paternal major histocompatibility complex MHC antigens, and it occurs during ‐compatible pregnancy. Method of Study Mares were mated carry or ‐incompatible pregnancies. these when pregnant non‐pregnant was measured horses with haplotypes unrelated mare Results While carrying pregnancies, demonstrated...
ABSTRACT Polyphenols derived from a variety of plants have demonstrated antimicrobial activity against diverse microbial pathogens. Legionella pneumophila is an intracellular bacterial pathogen that opportunistically causes severe inflammatory pneumonia in humans, called Legionnaires’ Disease, via replication within macrophages. Previous studies tea polyphenols attenuate L. mouse macrophages increased tumor necrosis factor (TNF) production. Sorghum bicolor sustainable cereal crop thrives...
Non-pharmaceutical interventions, such as contact tracing has been an important tool in controlling epidemic outbreaks. In this paper, we propose a non-Markovian, network-based mathematical model to assess the effectiveness of COVID-19 containment. To improve reliability model, empirically determined distributions were incorporated for sojourn times model's states. The first-order closure approximation was used derive expression threshold. Using survey data collected during 2020 fall...