A5043157472- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Lung Cancer Treatments and Mutations
- Drug Solubulity and Delivery Systems
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- S100 Proteins and Annexins
- Alcohol Consumption and Health Effects
- Cancer Immunotherapy and Biomarkers
- Lipid Membrane Structure and Behavior
- Inflammasome and immune disorders
- Pancreatic and Hepatic Oncology Research
- Galectins and Cancer Biology
- Sepsis Diagnosis and Treatment
- Catalytic C–H Functionalization Methods
- Neuroendocrine Tumor Research Advances
- Antibiotics Pharmacokinetics and Efficacy
- Circular RNAs in diseases
- Calcium signaling and nucleotide metabolism
- Platelet Disorders and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Cannabis and Cannabinoid Research
- Phosphodiesterase function and regulation
Ruijin Hospital
2021-2024
Shanghai Jiao Tong University
2021-2024
Zhejiang University
2024
Nanjing Drum Tower Hospital
2023
First People's Hospital of Nanning
2021-2023
China Pharmaceutical University
2023
Nanjing University
2022-2023
Kashi University
2021-2022
First Affiliated Hospital of GuangXi Medical University
2021
Guangxi Medical University
2021
Herein, we reported the enantioconvergent Csp3–Csp2 cross-coupling reaction with 1,4-dihydropyridine (DHP) derivatives via photoredox/nickel dual catalysis to access chiral products good yield and enantioselectivity. The operationally simple was carried out under mild conditions functional group tolerance. Due use of a stoichiometric equivalent aryl/alkenyl halides as coupling partners, sequential iterative synthesis could be achieved smoothly in one pot for position isomers stereoisomers....
Resveratrol (RSV) is known to possess anticancer properties in many types of cancers like breast cancer, which POLD1 may serve as a potential target. However, the mechanism RSV on triple negative cancer (TNBC) remains unclear. In present study, antitumor effects and TNBC cells were analyzed by RNA sequencing (RNA-seq), was then verified via cell counting kit-8 (CCK8), immunofluorescence, immunohistochemistry, Western Blot (WB), flow cytometry, hematoxylin-eosin (HE) staining. According...
Objectives The objective of this study is to evaluate whether PIV (Pan-Immune-Inflammation Value) and PILE [a score derived from PIV, lactate dehydrogenase (LDH), Eastern Cooperative Oncology Group Performance Status (ECOG PS)] can predict clinical outcome anti-PD-1/PD-L1 inhibitor combined with chemotherapy in patients extensive-stage (ES) small cell lung cancer (SCLC). Methods A total 53 ES-SCLC the control group trial (NCT03041311) were included study. was calculated as follows:...
Tumor metastasis contributes to the low overall survival of tumor patients, while transforming growth factor-β (TGFβ) has been recognized as a prominently promoting factor in development metastasis. Platelets reserve abundant TGFβ, which will be secreted peripheral blood after activation, and they are dominant source circulating TGFβ. Therefore, downregulation platelet-derived TGFβ is expected inhibit cells. Here, unfolded human serum albumin (HSA)-coated perfluorotributylamine (PFTBA)...
This review summarizes the latest research progress on photocatalytic reactions involving typical metal catalysts Sc, Ti, V, Cr, Mn, Fe, Co, Ni, and Cu, mainly focuses role...
The rechallenge of immune checkpoint inhibitors (ICI) is now an optional strategy for patients who discontinued ICI due to immune-related adverse events (irAEs) or disease progression. However, little data available the prognosis and prognostic factors receiving treatment in advanced lung cancer patients. Our study aimed explore efficacy, safety received anti-programmed cell death-1/programmed death ligand 1 (anti-PD-1/PD-L1) inhibitor rechallenge.In our retrospective cohort study,...
Background and Purpose Pro‐inflammatory cytokines are important in rheumatoid arthritis ( RA ) their production is mainly regulated by NF ‐ κB inflammasomes. Carboxyamidotriazole CAI exhibits potent anti‐inflammatory activities decreasing cytokines. Here, we have investigated NACHT , LRR PYD domains‐containing protein NALP inflammasomes a rat model of explored the therapeutic effects this involvement actions . Experimental Approach The anti‐arthritic were assessed adjuvant AA rats, using...
The clinical application of disulfiram (DSF) in cancer treatments is hindered by its rapid degradation the blood circulation. In this study, methoxy poly(ethylene glycol)- b-poly(lactide- co-glycolide)/poly(ε-caprolactone) (mPEG5k- b-PLGA2k/PCL3.4k) micelles were developed for encapsulation DSF using emulsification-solvent diffusion method. Medium chain triglyceride (MCT) was incorporated into mixed polymeric to improve drug loading reducing core crystallinity. Differential scanning...
The aim of this study was to develop an intravenous clarithromycin lipid emulsion (CLE) with good stability and excellent antibacterial activity. CLE prepared by the thin-film dispersed homogenization method. interaction between (CLA) cholesteryl hemisuccinate (CHEMS) confirmed DSC, FT-IR 1H NMR analysis. interfacial drug loading, thermal sterilization, freeze–thaw stability, in vitro vivo activity were investigated systematically. spectra showed that CHEMS (CLA: CHEMS, M ratio 1:2) could...
Carboxyamidotrizole (CAI) has been reported to suppress the production of tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β be effective in rats with adjuvant arthritis. The aim this study was investigate role CAI inflammatory bowel disease (IBD). We assessed effect dextran sodium sulfate-induced colitis. Inflammation scored histologically, potential mediators IBD were by immunohistochemical molecular biochemical approaches. CAI-treated colitis animals revealed much fewer signs...
Despite the promising initial anti-tumor efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), most advanced non-small-cell lung cancers (NSCLCs) progress eventually due to therapeutic resistance. V-Raf murine sarcoma viral oncogene homolog B1 (BRAF)V600E mutation has been considered as an uncommon that contributes acquired resistance for EGFR-TKIs. In presented case, BRAFV600E was detected resistance-mediated in a patient treated with osimertinib (a...
Along with the widespread use of immune checkpoint inhibitors (ICIs), there has been a surge in immune-related adverse events which can limit efficacy ICIs. However, to date, is paucity reports on renal (RAEs) related Therefore, this study incidence, risk factors, pathological features RAEs patients receiving ICI therapy and its association overall survival.The medical records who received at least 1 cycle anti-programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) monoclonal antibody...