Petra Fürstová
A5062165668- Schizophrenia research and treatment
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Obsessive-Compulsive Spectrum Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural and Behavioral Psychology Studies
- Electrolyte and hormonal disorders
- Neuroscience and Music Perception
- Visual perception and processing mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Botulinum Toxin and Related Neurological Disorders
- Face Recognition and Perception
- Mental Health Research Topics
- Genetic Neurodegenerative Diseases
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Mental Health and Psychiatry
National Institute of Mental Health
2017-2024
Abstract Schizophrenia is frequently associated with obesity, which linked neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto changes in schizophrenia. We obtained MRI-derived cortical and subcortical measures body mass index (BMI) from 1260 individuals schizophrenia 1761 controls 12 independent research sites within ENIGMA-Schizophrenia Working Group. jointly modeled statistical effects BMI using mixed effects. was additively structure many...
A specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate factor structure PANSS and develop such a method.Twenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis covariance, Exploratory Factor Analysis, Discriminant Function inspection resultant plots were performed.Exploratory returned 5 factors explaining 59% variance (positive, negative,...
Negative symptoms (NS) represent a detrimental symptomatic domain in schizophrenia affecting social and occupational outcomes.
Abstract Schizophrenia (SCHZ) notably impacts various human perceptual modalities, including vision. Prior research has identified marked abnormalities in organization SCHZ, predominantly attributed to deficits bottom-up processing. Our study introduces a novel paradigm differentiate the roles of top-down and processes visual perception SCHZ. We analysed eye-tracking fixation ground truth maps from 28 SCHZ patients 25 healthy controls (HC), comparing these with two mathematical models...
The aim of the current study was to explore changing interrelationships among clinical variables through stages schizophrenia in order assemble a comprehensive and meaningful disease model.Twenty-nine centers from 25 countries participated included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis visual inspection plots were performed.The results suggest that progression stages, there are correlations Positive Negative Syndrome Scale factors at...
In this study, we aimed to determine whether childhood trauma moderated the relationship between inflammation and cognitive functioning in persons with first-episode schizophrenia spectrum disorders (SSDs). We included data from 92 individuals who participated nationwide Early-Stage Schizophrenia Outcome study. These completed Childhood Trauma Questionnaire, provided a fasting blood sample for high-sensitivity C-reactive protein analysis, underwent extensive neuropsychological testing. The...
Abstract Background The aim of the current study was to explore effect gender, age at onset, and duration on long-term course schizophrenia. Methods Twenty-nine centers from 25 countries representing all continents participated in that included 2358 patients aged 37.21 ± 11.87 years with a DSM-IV or DSM-5 diagnosis schizophrenia; Positive Negative Syndrome Scale as well relevant clinicodemographic data were gathered. Analysis variance analysis covariance used, methodology corrected for...
The main aim of the present study is to determine role metabolites observed using proton magnetic resonance spectroscopy (1H-MRS) in obsessive-compulsive disorder (OCD). As literature describing biochemical changes OCD yields conflicting results, we focused on accurate metabolite quantification total N-acetyl aspartate (tNAA), creatine (tCr), choline-containing compounds (tCh), and myo-inositol (mI) anterior cingulate cortex (ACC) capture small metabolic between patients controls with...
Abstract Background Lateral ventricular enlargement represents a canonical morphometric finding in chronic patients with schizophrenia; however, longitudinal studies elucidating complex dynamic trajectories of volume change during critical early disease stages are sparse. Methods We measured lateral volumes 113 first-episode schizophrenia (FES) at baseline visit (11.7 months after illness onset, SD = 12.3) and 128 age- sex-matched healthy controls (HC) using 3T MRI. MRI was then repeated...
Abstract Background We need to better understand the risk factors and predictors of medication-related weight gain improve metabolic health individuals with schizophrenia. This study explores how trajectories antipsychotic medication (AP) use impact body early in course Methods recruited 92 participants first-episode psychosis (FEP, n = 92) during their first psychiatric hospitalization. prospectively collected weight, mass index (BMI), markers, exact daily exposure 6-week quantified...