A5075055263- Neurological disorders and treatments
- Pulmonary Hypertension Research and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
- Motor Control and Adaptation
- Transcranial Magnetic Stimulation Studies
- Robotic Locomotion and Control
- Cerebrospinal fluid and hydrocephalus
- Cardiovascular Disease and Adiposity
- Facial Nerve Paralysis Treatment and Research
- Cardiovascular Issues in Pregnancy
- Congenital Heart Disease Studies
- Ubiquitin and proteasome pathways
- Renin-Angiotensin System Studies
- Ear Surgery and Otitis Media
- Global Health Workforce Issues
- Functional Brain Connectivity Studies
- Neurological and metabolic disorders
- Fetal and Pediatric Neurological Disorders
- Reconstructive Facial Surgery Techniques
- interferon and immune responses
- Zebrafish Biomedical Research Applications
Universidade do Porto
2010-2025
Hospital de São João
2022-2025
Friedrich Miescher Institute
2018-2021
University of Basel
2018-2021
Instituto Português de Oncologia de Coimbra Francisco Gentil
2015
The mesencephalic locomotor region (MLR) is a key midbrain center with roles in locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant Parkinson's disease (PD), debate on its function remains. Here, we reveal the existence of functionally diverse neuronal populations distinct control body movements. We identify two spatially intermingled glutamatergic separable by axonal projections, mouse genetics, activity profiles, motor functions. Most spinally projecting...
Background and aim Endoscopic Third Ventriculostomy (ETV) is used to treat hydrocephalus, an abnormal cerebrospinal fluid accumulation in brain ventricles. By defining a new trajectory entry point interval, we establish standardized approach for FreeHand ETV, vital technique when specialized tools are unavailable, or during emergencies. Methods 187 MRIs were analyzed, with 30 having hydrocephalus. A pathway crossing the cranial bone, interventricular foramen (of Monro) tuber cinereum was...
In addition to insulin-sensitizing effects, adiponectin influences several mechanisms involved in pulmonary arterial hypertension (PAH) pathobiology. Insulin resistance has been associated with PAH, and elevated levels have described left heart failure (HF) as a response the increased metabolic stress. No studies performed right HF or PAH patients.Compared healthy controls, patients different plasma adipocytokine profile, higher insulin resistance, inflammatory systemic activation.A...
Polyphenols present in some alcoholic beverages have been linked to beneficial effects preventing cardiovascular diseases. found beer with anti-proliferative and anti-cancer properties are appealing the context of quasi-malignant phenotype pulmonary arterial hypertension (PAH). Our purpose was evaluate if chronic ingestion a xanthohumol-fortified (FB) would be able modulate pathophysiology experimental PAH. Male Wistar rats monocrotaline (MCT)-induced PAH (60 mg/kg) were allowed drink either...
Different neurostimulators for deep brain stimulation (DBS) come already with the ability to chronically sense local field potentials during stimulation. This invaluable new data has potential increase our understanding of disease-related activity patterns, their temporal evolution, and modulation in response therapies. It also gives opportunity unveil electrophysiological biomarkers ultimately bring adaptive therapies closer clinical practice. Unfortunately, there are still very limited...
The satisfaction with the medical profession has been identified as an essential factor for quality of care, wellbeing patients and healthcare systems' stability. Recent studies have emphasized a growing discontent physicians, mainly result changes in labor relations.To assess perception Portuguese residents about: correspondence residency previous expectations; degree specialty, place training; reasons dissatisfaction; opinion regarding clinical practice Portugal emigration...
Pulmonary arterial hypertension (PAH) is a progressive disease with poor prognosis. artery smooth muscle cells (PASMCs) play crucial role in PAH pathophysiology, displaying hyperproliferative, and apoptotic-resistant phenotype. In the present study, we evaluated potential therapeutic of terameprocol (TMP), an inhibitor cellular proliferation promoter apoptosis, well-established pre-clinical model induced by monocrotaline (MCT) studied biological pathways modulated TMP PASMCs. Wistar rats...
Abstract Purpose In the absence of an intraoperative CT or MRI setup, post-implantation confirmation electrode position in deep brain stimulation (DBS) requires patient transportation to radiology unit, prolonging surgery time. This project aims validate 3D fluoroscopy (3DF), a widely available tool Neurosurgical units, as method determine final position. Methods We performed retrospective study including 64 patients (124 electrodes) who underwent DBS at our institution. Intraoperative 3DF...
Purpose: Survivin is an inhibitor of apoptosis expressed in the vascular lesions pulmonary arterial hypertension (PAH) and also involved myocardial remodeling during left heart failure. The current work aims at: investigating right ventricular (RV) expression survivin smac/DIABLO (an survivin) throughout hemodynamic morphometric progression monocrotaline (MCT)-induced PAH; characterizing effects antagonist terameprocol artery smooth muscle cells (PASMC). Methods: Animal experiments were...
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a recognized treatment for drug-refractory Parkinson's disease (PD). However, therapeutic success depends on accuracy targeting. This study aimed to evaluate potential differences in placement first and second electrodes implanted, by comparing chosen electrode trajectories, STN activity detected during microelectrode recording (MER), mismatch between initially planned final positions each side. In this retrospective cohort...
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a recognized treatment for drug-refractory Parkinson's disease (PD). However, therapeutic success depends on accuracy targeting. This study aimed to evaluate potential differences in placement first and second electrodes implanted, by comparing chosen electrode trajectories, STN activity detected during microelectrode recording (MER), mismatch between initially planned final positions each side. In this retrospective cohort...
Abstract Deep brain stimulation (DBS) is a therapy applied in numerous neurologic diseases, yielding major improvements quality of life. Current implantable devices can record activity (in the form local field potentials) at site stimulation, providing window into neuropathological phenomena and potential to improve clinical care. Data-driven therapies often rely on tools process, visualize, analyze data. However, existing DBS are yet fully exploit devices’ sensing capabilities. We aimed...
The use of exercise training as a therapeutic and/or preventive strategy is gaining interest in pulmonary arterial hypertension (PH). We aimed to study the influence endurance monocrotaline (MCT) induced PH. Male Wistar rats were randomly divided according following groups: i) sedentary with MCT (60 mg/kg sc) or vehicle (SED+MCT and SED+V), ii) 4 week‐exercise before injection (EX+MCT EX+V) iii) after (MCT+EX V+MCT). Hemodynamic bi‐ventricular instrumentation conductance catheters was...
Pulmonary Arterial Hypertension (PAH) is characterized by progressive development of right ventricle (RV) hypertrophy, which commonly followed heart failure (HF) and premature death. The effect exercise training in the natural history PAH remains unknown. PURPOSE: we aimed to address if pre-conditioning can modulate RV response induced Monocrotaline (MCT). METHODS: Male Wistar rats were distributed according following groups: i) sedentary injected with MCT (60 mg/kg, sc) or vehicle (SED+MCT...