A5101685705- Chronic Myeloid Leukemia Treatments
- Cardiovascular Effects of Exercise
- Pulmonary Hypertension Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Muscle Physiology and Disorders
- Cardiovascular Function and Risk Factors
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac electrophysiology and arrhythmias
- dental development and anomalies
- Retinal Diseases and Treatments
- Bone and Joint Diseases
- Crystal structures of chemical compounds
- Immunotherapy and Immune Responses
- Metal complexes synthesis and properties
- Lymphoma Diagnosis and Treatment
- Biomedical Research and Pathophysiology
- Chemokine receptors and signaling
- Retinal Development and Disorders
- ECG Monitoring and Analysis
- Genetics, Aging, and Longevity in Model Organisms
- Oral microbiology and periodontitis research
- Mast cells and histamine
- Cardiovascular Issues in Pregnancy
- Brazilian Legal Issues
Universidade Federal da Grande Dourados
2025
Universidade do Porto
2010-2015
Centro de Investigación Biomédica en Red de Salud Mental
2014
Universitat Autònoma de Barcelona
2014
Hospital de Sant Pau
2014
Institute for Biotechnology and Bioengineering
2010
University of Trás-os-Montes and Alto Douro
2010
Hospital Pró-Cardíaco
2005
Novartis (Switzerland)
2002
The Christie Hospital
2002
O reconhecimento da multiparentalidade representa uma evolução no direito das famílias, refletindo as transformações nas dinâmicas familiares contemporâneas e ampliando a concepção de filiação. Esse instituto permite que um indivíduo tenha mais dois pais ou mães legalmente reconhecidos, com base em vínculos biológicos afetivos, criando estrutura familiar inclusiva. artigo analisa os efeitos jurídicos multiparentalidade, destacando suas implicações sucessório, onde filhos, sejam...
Research involving coordination chemistry with Schiff base hydrazones finds applications in various areas, particularly bioinorganic and biomedicine. This work aims to contribute this field by employing the ligand (E)-2-((2-(benzothiazol-2-yl)hydrazone)methyl)phenol (H2L), synthesized via a condensation reaction salicylic aldehyde. The was isolated, characterized, subsequently complexed nickel(II) chloride copper(II) nitrate, yielding three new crystalline complexes: [Ni(HL)2] (1),...
The "Sphyrna Odyssey 2019-2020" mission combined passive acoustic monitoring and environmental DNA (eDNA) to monitor marine mammals in the Mediterranean, focusing on areas impacted by heavy traffic. Sphyrna autonomous vessels, equipped with hydrophones, provided real-time detection of vocalizing species [1], while eDNA sampling from surface waters captured genetic traces over larger spatial areas, including busy shipping lanes [4]. Acoustic data species, detected even absence vocalizations,...
The present study aimed to test whether a chronic intermittent workload could induce an adaptive cardiac phenotype Chronic induced features of hypertrophy This was paralleled by protection against acute pressure overload insult heart may adapt favourably balanced demands, regardless the nature stimuli. submitting healthy and tolerable amounts workload, independently its nature, result in phenotype. Male Wistar rats were subjected treadmill running (Ex) (n = 20), with dobutamine (ITO) (2 mg...
Abstract Expression of BCR/ABL, a constitutively active tyrosine kinase, is primary event in the pathogenesis chronic myeloid leukemia (CML) and Ph‐positive acute lymphoblastic (Ph+ALL). Inhibition BCR/ABL kinase activity BV173 CML cell line with STI571 resulted significant overexpression 10‐kb novel mRNA, found to be human ortholog murine Bach2 , B‐cell‐specific transcription factor. The BACH2 cDNA >9,120 bp long includes an open reading frame 2,526 encoding protein basic leucine zipper...
<i>Objective:</i> To investigate the biological role of BCL-6 oncoprotein in breast cancer disease progression (recurrence and metastasis). <i>Methods:</i> The series consisted 93 consecutive female patients with primary median follow-up 10 years. expression was assessed vivo by immunohistochemistry real-time PCR. Breast cell lines some metastasis-related genes (CXCR4, Itgβ-3 FLT-1) were also analysed molecular techniques. Prognostic evaluation performed fitting a...
Cardiac cachexia is characterized by an imbalance between anabolic and catabolic factors that lead to weight loss. The present study addresses the preventive effect of exercise training on muscle wasting in animal model right ventricular failure induced monocrotaline (MCT) administration. After 4 weeks or cage living, male Wistar rats were injected with MCT (60mg/kg) (ExMCT SedMCT, respectively) saline (ExC SedC, respectively), sacrificed after additional 4week‐period movement confined...
Pulmonary Arterial Hypertension (PAH) is characterized by progressive development of right ventricle (RV) hypertrophy, which commonly followed heart failure (HF) and premature death. The effect exercise training in the natural history PAH remains unknown. PURPOSE: we aimed to address if pre-conditioning can modulate RV response induced Monocrotaline (MCT). METHODS: Male Wistar rats were distributed according following groups: i) sedentary injected with MCT (60 mg/kg, sc) or vehicle (SED+MCT...
The aim of the present study was to address if submission a stimuli that mimicked intermittent cardiac overload imposed by exercise training, would result in comparable cardioprotective phenotype. Male Wistar rats were submitted treadmill running (Ex,n=20), dobutamine (Dob; 2mg/kg,s.c.,n=20) or placebo administration (Cont,n=20) for 5 days/week during 8 weeks. After that, half sacrificed histological and biochemical analysis hemodynamic evaluation at baseline 2 hours left ventricular acute...
Right ventricle failure (RVF) is a major determinant of survival in pulmonary arterial hypertension (PAH). Exercise training was shown to be beneficial left but its impact on RVF remains unknown. We investigated whether exercise modulates the right ventricular response chronic pressure overload monocrotaline (MCT) model PAH. Male Wistar rats were submitted normal cage activity (SED+MCT) or treadmill (EXtreat+MCT) after establishment RV induced by MCT (60 mg/kg). attenuated cardiac...
Mendonca-Filho, Hugo-Tannus F; Pereira, Kelly; Augusto, Daniel; Vieira, S A; Fontes, Mariane; Cardoso, Monica; Campos, Luiz Antonio A Author Information