A5031589458- Lung Cancer Research Studies
- Lymphoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Viral-associated cancers and disorders
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- Retinal Diseases and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Fibroblast Growth Factor Research
- Ocular Oncology and Treatments
- Angiogenesis and VEGF in Cancer
- Cellular transport and secretion
- Eosinophilic Disorders and Syndromes
- AI in cancer detection
- Protein Tyrosine Phosphatases
- Cellular Mechanics and Interactions
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Brain Metastases and Treatment
- Immune Cell Function and Interaction
- Genetic and Kidney Cyst Diseases
- Cytokine Signaling Pathways and Interactions
- Bladder and Urothelial Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Retinal Imaging and Analysis
Shanxi Medical University
2022-2025
Linyi People's Hospital
2025
Affiliated Hospital of Qingdao University
2022-2024
Qingdao University
2022-2024
Peking University
2023
Center for Life Sciences
2023
Shanxi Provincial Cancer Hospital
2020
Peking University Shenzhen Hospital
2016-2017
Hong Kong University of Science and Technology
2016-2017
University of Hong Kong
2016-2017
The increased amount of tertiary lymphoid structures (TLSs) is associated with a favorable prognosis in patients lung adenocarcinoma (LUAD). However, evaluating TLSs manually an experience-dependent and time-consuming process, which limits its clinical application. In this multi-center study, we developed automated computational workflow for quantifying the TLS density tumor region routine hematoxylin eosin (H&E)-stained whole-slide images (WSIs). association between computerized...
Abstract Purpose Choroidal melanoma (CM), a kind of malignant tumor, is the main type Uveal and one half CM patients develop metastases. As member Eph/ephrin pathway that plays vital role in tumors, EphrinA3 (EFNA3) has been proved to promote tumorigenesis many tumors. But effect EFNA3 not studied yet. Through inhibiting angiogenesis, inducing apoptosis autophagy so on, Artesunate (ART) key anti-tumor including CM. However, exact mechanisms remain unclear. Methods The UALCAN TIMER v2.0...
This study aimed to investigate the expression and clinical relevance of androgen receptor (AR) in breast cancer. retrospective examined AR cancer its correlation with patients' clinicopathological immunohistochemical characteristics. A total 521 patient records were gathered assessed. Patients categorized as either positive or negative for expression, statistical analyses conducted using chi-square test, logistic regression SPSS 26.0, Kaplan-Meier analysis. was detected 83.7% patients...
<title>Abstract</title> Lung cancer is the leading cause of cancer-related mortality, with a notably low five-year survival rate due to limited availability effective treatments. Monoubiquitination histone H2B at lysine 120(uH2B) exerts tumor-suppressive effect in through multiple mechanisms, including regulation transcriptional activity and DNA damage response. Ring Finger Protein 20 (RNF20), key E3 ubiquitin ligase, plays central role this process. However, RNF20 lung adenocarcinoma (LUAD)...
Abstract Background Lung immune prognostic index (LIPI) is a marker of extensive-stage small cell lung cancer (ES-SCLC) patients received immunotherapy or chemotherapy. However, its ability in limited-stage SCLC (LS-SCLC) should be evaluated extensively. Methods We retrospectively enrolled 497 diagnosed as LS-SCLC between 2015 and 2018, clinical data included pretreatment lactate dehydrogenase (LDH), white blood count, absolute neutrophil count levels were collected. According to the LIPI...
Class III myosins (Myo3) and actin-bundling protein Espin play critical roles in regulating the development maintenance of stereocilia vertebrate hair cells, their defects cause hereditary hearing impairments. Myo3 interacts with Espin1 through its tail homology I motif (THDI), however it is not clear how specifically acts to regulate actin bundle assembly stabilization. Here we discover that THDI contains a pair repeat sequences capable independently strongly binding ankyrin repeats Espin1,...
Objective: The prognostic nutritional index (PNI) is a significant factor in diffuse large B cell lymphoma, follicular lymphoma and other malignancies. current study aimed to explore its role extranodal natural killer/T (ENKTL). Methods: Patients diagnosed with ENKTL treated during 2002 2018 (n=184) were retrospectively recruited. PNI was calculated from albumin concentration (g/L) total lymphocyte count(*109/L). association of overall survival (OS) or progression-free (PFS) assessed...
Though several nomograms have been established to predict the survival probability of patients with small-cell lung cancer (SCLC), none involved enough variables. This study aimed construct a novel prognostic nomogram and compare its performance other models.
Prophylactic cranial irradiation (PCI), as an essential part of the treatment limited-stage small-cell lung cancer (LS-SCLC), inevitably leads to neurotoxicity. This study aimed construct a brain metastasis prediction model and identify low-risk patients avoid PCI; 236 with LS-SCLC were retrospectively analyzed divided into PCI (63 cases) non-PCI groups (173 cases). The nomogram was developed based on variables determined by univariate multivariate analyses in group. According cutoff score,...
AIM: To observe the therapeutic effect of conbercept on diabetic macular edema (DME) complicated with nephropathy (DN). METHODS: In this retrospective study, 54 patients (54 eyes) that diagnosed as DME from January 2017 to October 2021 were collected. The divided into two groups: DN (25 eyes), and without (29 eyes). General conditions collected before treatment, laboratory tests include fasting blood glucose, HbA1c, microalbumin/creatinine, serum creatinine. Optical coherence tomography...
Abstract Background Abnormalities of FGFR1 have been reported in multiple malignancies, which proposes as a potential target for precision treatment, whereas drug resistance remains formidable obstacle simultaneously. Methods RNA-seq analysis, mouse tumor models, and flow cytometry were performed to identify that the was T-ALL. RNA-seq, ATAC-seq, targeted metabolomics surface sensing translation (SUnSET) assay, western blot assays, qRT-PCR used investigate underlying mechanisms...
BACKGROUND: At present, peripheral blood markers are easily accessible information and clinically valuable prognostic indicators in extranodal nasal-type natural killer/T-cell lymphoma (ENKTCL). Nevertheless, the role of its comprehensive score ENKTCL remains to be determined. OBJECTIVE: Therefore, this study aimed investigate effect inflammation on ENKTCL. METHODS: The retrospective included 183 patients with Univariate Cox regression analyses least absolute shrinkage selection operator...
Aspartate aminotransferase (AST), an indicator of liver cell damage, was related to the prognosis certain malignant tumors.
Qi et al. recently proposed a nomogram to reveal the prognostic value of peripheral blood inflammatory indexes (named Risk) and predict overall survival (OS) in limited-stage small cell lung cancer (LS-SCLC). However, it hasn't undergone external application so far. This study aimed verify role Risk as variable OS apply externally.We used retrospective analysis clinical data 254 patients diagnosed LS-SCLC Shanxi Cancer Hospital from January 2015 December 2018 Qi's externally. We also...
<title>Abstract</title> <bold>Background</bold>Aspartate aminotransferase (AST), an indicator of liver cell damage, was related to the prognosis certain malignant tumors. This study examined predictive value AST in patients with extranodal natural killer/T lymphoma (ENKTL).<bold>Methods</bold>We reviewed 183 cases diagnosed ENKTL and selected 26 U/L as optimum cut-off AST. We used univariate multivariate Cox regression compare different groups' overall survival (OS) progression-free...
Abstract Background: Choroidal melanoma (CM) accounts for 70% of uveal melanomas and is prone to metastasize invade. Previous studies have reported that forkhead box protein 3 (FOXP3) associated with carcinogenesis, however, the effect FOXP3 on CM remains unclear. The purpose study explore role in progression elucidate its related mechanisms. Methods: expression was detected clinical specimens cells. We then established a cell line stable knockout as well transiently overexpressed FOXP3,...