A5103020577- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- Nanopore and Nanochannel Transport Studies
- Cancer Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Immune cells in cancer
- Immunotherapy and Immune Responses
- MXene and MAX Phase Materials
- Ion channel regulation and function
- Metal complexes synthesis and properties
- Click Chemistry and Applications
- Antimicrobial Peptides and Activities
- Biochemical and Molecular Research
- Cancer, Stress, Anesthesia, and Immune Response
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Hydrogels: synthesis, properties, applications
- Dendrimers and Hyperbranched Polymers
- Enzyme function and inhibition
- Covalent Organic Framework Applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Second Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Zhengzhou University
2024
Jilin University
2018
Abstract The inherent immune and metabolic tumor microenvironment (TME) of most solid tumors adversely affect the antitumor efficacy various treatments, which is an urgent issue to be solved in clinical cancer therapy. In this study, a mitochondrial localized situ self‐assembly system constructed remodel TME by improving immunogenicity disrupting plasticity cells. peptide‐based drug delivery can pre‐assembled into nanomicelles vitro form functional nanofibers on mitochondria through...
Abstract Nanochannels based on smart DNA hydrogels as stimulus‐responsive architecture are presented for the first time. In contrast to other responsive molecules existing in nanochannel monolayer configurations, three‐dimensional networks with space negative charges, ion flux and rectification ratio significantly enhanced. Upon cyclic treatment K + ions crown ether, hydrogel states could be reversibly switched between less stiff networks, providing gating mechanism of nanochannel. Based pH...
Tumor cells elicit metabolic reprogramming to establish an immunosuppressive tumor microenvironment (TME) for escaping from immunosurveillance. Therefore, interrupting the adaptation of may be a promising strategy TME immunomodulation, favoring immunotherapy. In this work, tumor-specific peroxynitrite nanogenerator APAP-P-NO is constructed that can selectively disrupt homeostasis in melanoma cells. Stimulated by melanoma-characteristic acid, glutathione, and tyrosinase, efficiently generate...
Abstract Cancer stem‐like cells (CSCs), capable of indefinite self‐renewal and differentiation, are considered to be the root cause tumor radiotherapy (RT) resistance. However, CSCs‐targeted therapy still remains a great challenge because they commonly located in deep making drugs hard approach, their hypoxic acidic niche can further aggravate radioresistance. Herein, based on finding that CSCs highly express carbonic anhydrase IX (CAIX) cell membrane, CAIX‐targeted induced situ...
Abstract Limited ability to elicit cellular immune responses has restricted the effectiveness of conventional adjuvants in context cancers. Recent advancements innate activation mechanism investigations have paved way for implementation a “bottom‐up” approach development novel adjuvants. Herein, simple hydrogel adjuvant with uniformly organized nanoscale microstructure, termed MnP gel is devised, by employing self‐assembling peptides incorporated manganese ions (Mn 2+ ). exhibits Mn...
Abstract Inspired by biological channels, metal‐organic framework (MOF) membranes with sub‐nanometer sized channels offer an ideal platform to construct high‐performance artificial nanofluidic system. However, fabricating long‐range ordered MOF is still a significant challenge. Herein, superspreading‐confined assembly method developed prepare large‐scale oriented 2D (Zn‐TCPP (TCPP = meso‐tetra(4‐carboxyphenyl) porphine)) membranes. The superspreading of reactant liquid under oil phase form...
Abstract Drug resistance has always been a huge challenge that should be urgently conquered to improve the efficacy of anticancer drugs. Herein, synergistic Pt(IV) prodrug, Npx‐p p ‐Pt(IV), is proposed, combining dual responsive behavior with drug resistance‐related pathways deactivation. First, ‐Pt(IV) can in situ form supramolecular self‐assembly nanofiber structure on cancer cell surface triggered by phosphatase, which confines tumor and effectively enhances cellular uptake cisplatin,...
Abstract Abundant glutathione (GSH) is a biological characteristic of lots tumor cells. A growing number studies are utilizing GSH depletion as an effective adjuvant therapy for tumor. However, due to the compensatory effect intracellular biosynthesis, hard be completely exhausted and strategy remains challenging. Herein, we report l -buthionine-sulfoximine (BSO)-based hypertoxic self-assembled peptide derivative (NSBSO) with dual functions biosynthesis inhibition selective ferroptosis...
Abstract Radiosensitizers hold great promise for enhanced cancer radiotherapeutics. However, apoptosis evasion of cancerous cells usually limits the efficiency radiosensitive strategies. Herein, an in situ self‐assembled supramolecular antagonist is developed to reinforce treatment outcome radiotherapy by inhibiting tumor evasion. The composed peptide functionalized with apoptosis‐inducing SmacN7 and alkaline phosphatase (ALP)‐responsive group. Upon reaching site, can form membrane‐localized...
Tumor cells harness Ca
Abstract Fractionated radiotherapy (FRT), typically delivering low‐dose radiation of 2 Gy per fraction, has been used as the main clinical treatment regimen for various tumors. However, its therapeutic efficacy is severely hindered by inadequate pro‐immunogenic effect and ionizing radiation‐induced immunosuppression. Herein, a peptide nanoregulator (SP ER ‐NO‐Ind) constructed from self‐assembling peptides that can enrich nitric oxide (NO) at endoplasmic reticulum (ER) inhibit indoleamine...
Abstract Nanochannels based on smart DNA hydrogels as stimulus‐responsive architecture are presented for the first time. In contrast to other responsive molecules existing in nanochannel monolayer configurations, three‐dimensional networks with space negative charges, ion flux and rectification ratio significantly enhanced. Upon cyclic treatment K + ions crown ether, hydrogel states could be reversibly switched between less stiff networks, providing gating mechanism of nanochannel. Based pH...
Photodynamic therapy (PDT) has attracted much attention in cancer treatment due to its tumor selectivity and noninvasive nature. Recent studies have demonstrated that PDT mediated reactive oxygen species (ROS) generation microenvironment (TME) synergistically improves the efficacy of immune checkpoint blockade (ICB) therapy. However, instability short half-life ROS generated by limit clinical applications. Herein, a coassembled peptide hydrogel comprising two peptides contained same assembly...
Multimodality imaging-navigated precise phototherapy has been well-established as a promising strategy for enhancing the diagnostic and therapeutic efficiency of cancer in preclinical trials. However, proper theranostic agents with adequate biosafety biological efficacy well simple components preparations are still great demand to promote clinical translation this regimen. Here, we developed multifunctional nanosystem based on self-assembly FDA-approved indocyanine green (ICG) 125I-labeled...
The management of multibacterial infections remains clinically challenging in the care and treatment chronic diabetic wounds. Photodynamic therapy (PDT) offers a promising approach to addressing bacterial infections. However, limited target specificity internalization properties traditional photosensitizers (PSs) toward Gram-negative bacteria pose significant challenges their antibacterial efficacy. In this study, we designed an iron heme–mimetic PS (MnO2@Fe-TCPP(Zn)) based on dependence...
Chemotherapy and radiotherapy in combination with sequence regimens are recognized as the current major strategy for suppressing postoperative tumor recurrence. However, systemic side effects poor in-field cooperation of two therapies seriously impair therapeutic efficacy patients. The brachytherapy chemotherapy through innovative biomaterials has proven to be an important achieve synergistic in-time in-field. chemoradiotherapy, far we know, there few relevant reports. Herein, injectable...