A5033934279- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Aquaculture disease management and microbiota
- Kruppel-like factors research
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Stoma care and complications
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Cancer survivorship and care
- Plant Parasitism and Resistance
- Immune Response and Inflammation
- Invertebrate Immune Response Mechanisms
- Antimicrobial Peptides and Activities
- Blood Coagulation and Thrombosis Mechanisms
- Alcohol Consumption and Health Effects
- Phagocytosis and Immune Regulation
- Signaling Pathways in Disease
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Zebrafish Biomedical Research Applications
- Dietary Effects on Health
Henan Provincial People's Hospital
2025
Institute of Hematology & Blood Diseases Hospital
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
China Pharmaceutical University
2022
Tianjin Medical University
2018-2022
Shandong Agricultural University
2021-2022
Ministry of Agriculture and Rural Affairs
2021-2022
Hubei University
2017-2022
Dalian University
2021-2022
Second Hospital of Tianjin Medical University
2022
Local flow patterns determine the uneven distribution of atherosclerotic lesions. This research aims to elucidate mechanism regulation nuclear translocation Yes-associated protein (YAP) under oscillatory shear stress (OSS) in atheroprone phenotype endothelial cells (ECs). We report here that OSS led tyrosine phosphorylation and strong, continuous YAP ECs is dependent on integrin α5β1 activation. overexpression blunted anti-atheroprone effect an α5β1–blocking peptide (ATN161) Apoe–/– mice....
The Hippo/Yes-associated protein (YAP) pathway has pivotal roles in innate immune responses against pathogens macrophages. However, the role of YAP macrophages during atherosclerosis and its mechanism activation remain unknown. Here, we find that overexpression myeloid cells aggravates atherosclerotic lesion size infiltration macrophages, whereas deficiency reduces plaque. Tumor necrosis factor receptor-associated 6 (TRAF6), a downstream effector interleukin-1β (IL-1β), triggers...
Abstract Limited ability to elicit cellular immune responses has restricted the effectiveness of conventional adjuvants in context cancers. Recent advancements innate activation mechanism investigations have paved way for implementation a “bottom‐up” approach development novel adjuvants. Herein, simple hydrogel adjuvant with uniformly organized nanoscale microstructure, termed MnP gel is devised, by employing self‐assembling peptides incorporated manganese ions (Mn 2+ ). exhibits Mn...
Background: Metabolic syndrome is related to cardiovascular diseases, which attributed in part, arterial stiffness; however, the mechanisms remain unclear. The present study aimed investigate molecular of metabolic syndrome–induced stiffness and identify new therapeutic targets. Methods: Arterial was induced by high-fat/high-sucrose diet mice, quantified Doppler ultrasound. Four-dimensional label-free quantitative proteomic analysis, affinity purification mass spectrometry,...
The tumor microenvironment is replete with proteinases. As a sensor of proteinases, proteinase activated receptor 2 (PAR2) plays critical roles in tumorigenesis. We showed that PAR2 and its activating were coexpressed different colon cancer cell lines, including HT29. Inactivating or knockdown significantly not only reduced proliferation vitro but also inhibited tumorigenicity HT29 vivo. In addition, activation promoted DNA synthesis upregulated Cyclin D1 activity at both transcriptional...
Endothelial cells regulate vascular tone by producing both relaxing and contracting factors to control the local blood flow. Hypertension is a common side effect of mTORC1 (mammalian target rapamycin complex 1) inhibitors. However, role endothelial in hypertension remains elusive. The present study aimed determine Ang II (angiotensin II)-induced underlying mechanism. activity was increased vitro vivo. Blood pressure higher Tie-2-Cre-mediated regulatory associated protein mTOR rapamycin;...
Hesperetin (HES) is a dihydroflavone with the molecular formula of C16H14O6. It has been reported that antioxidant and anticancer effects. Recent studies showed it can also regulate immune responses. To assess its potential function as vaccine adjuvant, we formulated HES inactivated B16F10 melanoma cells determined whether would enhance activation antigen-presenting by experiments in vivo vitro. We found activated PI3K-Akt signalling pathway (APCs), enhanced cytotoxic T lymphocyte (CTL)...
Purpose: The impact of hepatic lipid accumulation on hyperuricemia presents an intriguing research avenue, particularly in light existing studies linking obesity with hyperuricemia. Nevertheless, there remains a scarcity quantitative investigations into the correlation between liver fat content (LFC) and among prediabetic cohorts, notably within Chinese demographic. Patients Methods: This cross-sectional study was conducted at Health Management Center Henan Provincial People's Hospital...
T lymphocytes synergize with the cellular immune system to promote hepatocyte regeneration. The T‐cell receptor (TCR) repertoire is closely associated host response and regenerative proliferation. High‐throughput sequencing of TCR provides deep insight into monitoring microenvironment. Here, we aimed determine role TCRβ in liver regeneration (LR). We investigated hepatic chain‐deficient ( tcrb –/– ) mice by two‐thirds partial hepatectomy (PHx) method. Our results demonstrated that revealed a...
PURPOSE: We constructed a self-management program for rectal cancer survivors with colostomies and evaluated the effect of on self-efficacy, ability, incidence stomal peristomal complications. DESIGN: A prospective, nonrandomized clinical trial. SUBJECTS AND SETTING: Participants were recruited from 4 proctology departments in tertiary hospital northeast China. Fifty-five assigned to intervention group 56 control group; 26 lost follow-up. Therefore, data analysis was based 43 participants 42...
The maintenance and expansion of cancer stem-like cells (CSCs) is necessary for metastasis. Although protease-activated receptor 2 (PAR2) strongly associated with colorectal (CRC) progression, it unclear how regulates distal metastasis, no studies have shown the involvement CSCs. In this study, we demonstrated that high PAR2 protein expression was correlated metastatic CRC poor prognosis in patients stage III-IV CRC. CSCs from cell lines showed higher levels than corresponding non-CSCs,...
ABSTRACT Endothelial progenitor cell (EPC) dysfunction contributes to diabetes‐induced delay in endothelium repair after vessel injury, prominently associated with diabetic cardiovascular complications such as neointima formation. ATP‐binding cassette transporter G1 (ABCG1) promotes cholesterol efflux HDL, which may favorably affect EPC function. However, whether ABCG1 improves function, especially diabetes, remains unknown. Here we investigated the role of EPCs by using Tie2‐mediated...
Chemotherapy-induced thrombocytopenia (CIT) is a severe complication in patients with cancer that can lead to impaired therapeutic outcome and survival. Clinically, options for CIT are limited by adverse effects high economic burdens. Here, we demonstrate ketogenic diets alleviate both animals humans without causing thrombocytosis. Mechanistically, diet-induced circulating β-hydroxybutyrate (β-OHB) increased histone H3 acetylation bone marrow megakaryocytes. Gain- loss-of-function...
Hematopoietic differentiation is controlled by both genetic and epigenetic regulators. Long noncoding RNAs (lncRNAs) have been demonstrated to be important for normal hematopoiesis, but their function in erythropoiesis needs further explored. We profiled the transcriptomes of 16 murine hematopoietic cell populations deep RNA sequencing identified a novel lncRNA, Gm15915, that was highly expressed erythroid-related progenitors erythrocytes. For this reason, we named it lncEry. also lncEry...