Audrey T. Lin
A5030206317- Indigenous Studies and Ecology
- Genetic diversity and population structure
- Marine animal studies overview
- Chromosomal and Genetic Variations
- Forensic and Genetic Research
- Wildlife Ecology and Conservation
- CRISPR and Genetic Engineering
- Human-Animal Interaction Studies
- Advanced biosensing and bioanalysis techniques
- Genomics and Phylogenetic Studies
- Archaeology and ancient environmental studies
- RNA and protein synthesis mechanisms
- Genetic and phenotypic traits in livestock
- Yersinia bacterium, plague, ectoparasites research
- Forensic Anthropology and Bioarchaeology Studies
- Fish Ecology and Management Studies
- Animal Diversity and Health Studies
- Ubiquitin and proteasome pathways
- HIV Research and Treatment
- Plant Taxonomy and Phylogenetics
- Animal Behavior and Welfare Studies
- Evolution and Paleontology Studies
- Pleistocene-Era Hominins and Archaeology
- Environmental DNA in Biodiversity Studies
- Genetic Mapping and Diversity in Plants and Animals
National Museum of Natural History
2020-2025
Smithsonian Institution
2020-2025
American Museum of Natural History
2023-2025
Oxford Archaeology
2019-2024
University of Oxford
2016-2024
Dogs were the first domestic animal, but little is known about their population history and to what extent it was linked humans. We sequenced 27 ancient dog genomes found that all dogs share a common ancestry distinct from present-day wolves, with limited gene flow wolves since domestication substantial dog-to-wolf flow. By 11,000 years ago, at least five major lineages had diversified, demonstrating deep genetic of during Paleolithic. Coanalysis human reveals aspects mirror humans,...
Archaeological evidence indicates that pig domestication had begun by ∼10,500 y before the present (BP) in Near East, and mitochondrial DNA (mtDNA) suggests pigs arrived Europe alongside farmers ∼8,500 BP. A few thousand years after introduction of Eastern into Europe, however, their characteristic mtDNA signature disappeared was replaced haplotypes associated with European wild boars. This turnover could be accounted for substantial gene flow from local boars, although it is also possible...
Domestic dogs have been central to life in the North American Arctic for millennia. The ancestors of Inuit were first introduce widespread usage dog sledge transportation technology Americas, but whether adopted local Palaeo-Inuit or introduced a new population region remains unknown. To test these hypotheses, we generated mitochondrial DNA and geometric morphometric data skull dental elements from total 922 wolves spanning over 4500 years. Our analyses revealed that sites dating 2000 BP...
Dire wolves (Aenocyon dirus) are extinct predators of Pleistocene North America. Although phenotypically similar to living (Canis lupus), dire have yet be placed confidently in the canid family tree. We generated 3.4x and 12.8x paleogenomes from two well-preserved dating > 13,000 72,000 years ago, estimated consensus species trees for these 10 species. Our results revealed that ~2/3 wolf ancestry is derived a lineage sister clade comprising gray wolf, coyote, dhole, remaining ~1/3 near...
Occupied between ~10,300 and 9300 years ago, the Pre-Pottery Neolithic site of Aşıklı Höyük in Central Anatolia went through early phases sheep domestication. Analysis 629 mitochondrial genomes from this numerous sites Anatolia, southwest Asia, Europe, Africa produced a phylogenetic tree with excessive coalescences (nodes) around Neolithic, potential signature domestication bottleneck. This is consistent archeological evidence management at which transitioned residential stabling to open...
Manioc-also called cassava and yuca-is among the world's most important crops, originating in South America early Holocene. Domestication for its starchy roots involved a near-total shift from sexual to clonal propagation, almost all manioc worldwide is now grown stem cuttings. In this work, we analyze 573 new published genomes, focusing on traditional varieties Americas wild relatives herbaria, reveal effects of clonality. We observe kinship over large distances, maintenance high genetic...
Domestic cats were derived from the Near Eastern wildcat (Felis lybica), after which they dispersed with people into Europe. As did so, it is possible that interbred indigenous population of European wildcats silvestris). Gene flow between incoming domestic animals and closely related wild species has been previously demonstrated in other taxa, including pigs, sheep, goats, bees, chickens, cattle. In case cats, a lack nuclear, genome-wide data, particularly wildcats, made difficult to either...
Significance The human genome is “littered” with remnants of ancient retrovirus infections that invaded the germ line our ancestors. Only one these may still be proliferating, named HERV-K HML-2 (HK2). Not all humans have same HK2 viruses in their genomes. Here we show specific uncommon HK2, which lies close to a gene involved dopaminergic activity brain, more frequently found drug addicts and thus significantly associated addiction. We experimentally can manipulate nearby genes. Our study...
Ancestral Coast Salish societies in the Pacific Northwest kept long-haired "woolly dogs" that were bred and cared for over millennia. However, dog wool-weaving tradition declined during 19th century, population was lost. In this study, we analyzed genomic isotopic data from a preserved woolly pelt "Mutton," collected 1859. Mutton is only known example of an Indigenous North American with dominant precolonial ancestry postdating onset settler colonialism. We identified candidate genetic...
Atlantic sturgeon (
Domestic cats were derived from the Near Eastern wildcat (Felis lybica), after which they dispersed with people into Europe. As did so, it is possible that interbred indigenous population of European wildcats silvestris). Gene flow between incoming domestic animals and closely related wild species has been previously demonstrated in other taxa including pigs, sheep, goats, bees, chickens cattle. In case cats, a lack nuclear, genome-wide data, particularly wildcats, made this possibility...
Abstract Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections that make up to 8% the human genome. Although these elements mostly fragmented and inactive, many proviruses belonging HERV-K (HML-2) family, only lineage still proliferating in genome after human-chimpanzee split, have intact open reading frames, some encoding for accessory genes called np9 rec interact with oncogenic pathways. Many studies established transient expression ERVs both stem cells cancers...
Abstract Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections that make up 8% the human genome. Although these elements mostly fragmented and inactive, many proviruses belonging to HERV-K (HML-2) family, youngest lineage in genome, have intact open reading frames, some encoding for accessory genes called np9 rec interact with oncogenic pathways. Many studies established ERVs transiently expressed both stem cells cancer, resulting aberrant self-renewal uncontrolled...