A5101946861- Reproductive Biology and Fertility
- Ovarian function and disorders
- Prenatal Screening and Diagnostics
- Renal and related cancers
- Liver Disease Diagnosis and Treatment
- Sperm and Testicular Function
- Liver Disease and Transplantation
- Cervical Cancer and HPV Research
- Neurosurgical Procedures and Complications
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Diabetes and associated disorders
- Infectious Diseases and Mycology
- Pulsed Power Technology Applications
- Lung Cancer Treatments and Mutations
- Microbial Fuel Cells and Bioremediation
- CO2 Sequestration and Geologic Interactions
- Cell death mechanisms and regulation
- Ovarian cancer diagnosis and treatment
- Urological Disorders and Treatments
- Pharmacological Effects of Natural Compounds
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 diagnosis using AI
- Glycosylation and Glycoproteins Research
- Traditional Chinese Medicine Analysis
Center for Human Reproduction
2019-2021
Shanghai Sixth People's Hospital
2012-2021
Shanghai Jiao Tong University
2014-2021
Nanjing General Hospital of Nanjing Military Command
2021
Jiangsu Cancer Hospital
2021
University of South Carolina
2020
Tarim University
2020
Xinjiang Medical University
2015-2019
Henan Agricultural University
2019
Jackson Laboratory
2019
Mouse oocytes undergo two successive meiotic divisions to generate one large egg with small polar bodies. The are essential for preserving the maternal resources support embryonic development. Although previous studies have shown that some guanosine triphosphatases, such as RAC, RAN, and CDC42, play important roles in cortical polarization spindle pole anchoring, no cytokinesis when mutant forms of these genes expressed mouse oocytes. Here, we show ADP-ribosylation factor 1 (ARF1) plays an...
Summary Interleukin‐21 ( IL ‐21) participates in tissue damage various immune‐mediated diseases. Its role the pathogenesis of chronic active hepatitis B CAHB ) has not been clarified. The frequency circulating ‐21 + T cells and levels serum intrahepatic have characterized 70 patients, 32 inactive carrier IC ), 18 C CHC 20 healthy controls HC ). Their potential association with liver injury was analysed. percentages CD 3 8 − patients were significantly higher than that , P < 0.001)...
To determine whether 4 cytoplasmic granulation patterns of human metaphase II oocytes have a predictive value for in vitro fertilization outcomes.A retrospective cohort study.An academically affiliated private clinical infertility and research center.A total 2,690 consecutive fresh autologous collected from women aged 41.2 ± 5.0 years between 2017 2019.Determination pattern every oocyte during intracytoplasmic sperm injection as fine, central, dispersed, newly introduced uneven...
Abstract Given attention to both contraception and treatment of infertility, there is a need identify genes sequence variants required for mammalian fertility. Recent unbiased mutagenesis strategies have expanded horizons genetic control reproduction. Here we show that male mice homozygous the ethyl‐nitroso‐urea‐induced ferf1 (fertilization failure 1) mutation are infertile, producing apparently normal sperm does not fertilize oocytes in standard fertilization vitro assays. The single‐base...
Objectives: To identify whether Nestin-positve cells or Nestin-negative in pancreas enrich potential pancreatic stem/progenitor cells. Methods: We generated transgenic mice carrying enhanced green fluorescent protein (EGFP) under the control of nestin second-intronic enhancer and subsequently divided their embryonic into different subpopulations according to expression EGFP CD24 characterized these by vitro culture. Results: The correlated well with that endogenous Nestin. Only...
Chronic hepatitis B virus (HBV) infection is commonly considered to occur as a result of disturbance the immune system. T-box expressed in T cells (T-bet) an essential transcription factor for helper (Th) cell differentiation and function. The aim this study was investigate effect T-bet overexpression on Th possible mechanism chronic (CHB) patients. CD4+ from peripheral blood 23 CHB patients, 8 acute (AHB) patients 10 healthy controls were isolated. mRNA expression detected by quantitative...
This article was originally published in Proteomics 2010, 10 , 3800–3810, DOI 10.1002/pmic.201000297
(Abstracted from Nat Cell Biol 2021;23:314–321) Despite it being current practice in vitro fertilization (IVF) protocols to exclude aneuploid embryos diagnosed through preimplantation genetic testing (PGT-A), remains controversial whether or not this improves IVF outcomes. Both pregnancies and spontaneous demonstrate similar levels of mosaicism (12% vs 6.3%).
Background: Bovine papilloma is a neoplastic disease caused by bovine papillomaviruses (BPVs), which were recently divided into 5 genera and at least 24 genotypes.Objectives: The complete genome sequence of BPV type 15 (BPV Aks-02), novel putative from skin samples infected cows in Southern Xinjiang China, was determined collecting warty lesions, followed DNA extraction amplicon sequencing.Methods: analyzed initially polymerase chain reaction (PCR) using the degenerate primers FAP59...
The electroplated hard chromium coat was selected as precoating to improve surface properties of 40Cr. Then electron beam alloying process experimentalized. relation rules were summarized between parameters and overall by morphology observation, energy spectrum analysis, EDX analysis in section, XRD. Experiment results showed that the microcracks appeared on specimen. Microcracks could disappear when orthogonal experimental optimum used. matrix metal elements diffused into coating after...
Clinical trials indicated that PD-1/PD-L1 inhibitors significantly improve the survival rate of patients with advanced non-small cell lung cancer (NSCLC) and induce immune-related adverse events (irAEs). Thus, molecular immune characteristics during inhibitor therapy are worth investigating further. We report case a 62-year-old male patient diagnosed stage IIIA squamous carcinoma (SQCC) who responded to neoadjuvant adjuvant nivolumab combined chemotherapy but died from anastomosis leakage...
Adequate operation interspace is the premise of laparoscopy, and carbon dioxide (CO2) was an ideal gas for forming lacuna. A retroperitoneal space used to form in laparoscopic radical nephrectomy by making ballooning, has no relative complete airtight serous membrane, therefore CO2 absorption may be greater than transperitoneal nephrectomy. Excess induce hypercapnemia further cause physiopathological change respiratory circulatory system. Therefore, exact evaluation amount which eliminated...
Objective To explore the clinical value of lung protective ventilation strategy in thoracoscopic and laparoscopic radical resection esophageal cancer. Methods The prospective study was conducted. The clinicopathological data 160 patients who underwent cancer at Tumor Hospital Affiliated to Xinjiang Medical University between June 2015 2016 were collected. All undergoing allocated respectively into experimental group control according random number table, intraoperative single-lumen...