Antibiotics that possess the capability to inhibit or eradicate bacteria have been widely employed in fields of agriculture and veterinary medicine over years. However, excessive use antibiotics has led significant challenges regarding antibiotic pollution food. Given established risks contamination need for regulatory compliance, various detection techniques emerged, including chromatography, immunoassays, microbiological assays, microfluidic analysis. Among these methods, luminescent...

Background/Objectives: The gut microbiota is increasingly recognized as playing an important role in the development of obesity, but influence gender remains elusive. Using a large cohort Chinese adults, our study aimed to identify differences function body mass index (BMI) and investigate specific features within these differences. Methods: Five hundred fifty-one participants were categorized underweight, normal, overweight, or obese, based on their BMI. Fecal microbiome composition was...

Sonodynamic therapy (SDT) combines ultrasound and sonosensitizers to produce toxic reactive oxygen species (ROS) for cancer cell killing. Due the high penetration depth of (US), SDT breaks barrier conventional photodynamic treatment deeply seated tumors. A key point enhance therapeutic efficiency is development novel with promoted ability ROS production. Herein, ultrathin Fe-doped bismuth oxychloride nanosheets rich vacancies bovine serum albumin coating on surface are designed as...

The development of reliable probe technology for the detection bisulfite (HSO3-) in situ food and biological samples is contributing significantly to quality safety assurance as well community health. In this work, a responsive probe, EHDI, developed ratiometric fluorescence HSO3- aqueous solution, meat samples, living cells. designed based on triggered 1,4-addition electron deficit C = bond EHDI. As result specific 1,4-addition, π-conjugation system was destructed, resulting blue shifts...

Abstract Matrix metalloproteinases (MMPs) are a class of zinc‐dependent endopeptidases that play important roles in disease progression. High expression MMPs is associated with various diseases, including cancer, cardiovascular neurological and inflammatory diseases. For better understanding the these diseases’ development potential early diagnosis treatment monitoring, number sensors have recently been developed for detection vitro vivo. These designed mainly based on exploration MMPs’...

The special band structure of three-dimensional Dirac semimetal (3D DSM) makes it show strong nonlinear optical characteristics in the terahertz region, which provides a new way to develop devices with low threshold. In this paper, we theoretically study bistability (OB) transmitted light multilayer 3D DSM embedded two one-dimensional photonic crystals (1D PhC). topological edge state (TES) excited by 1D PhC heterostructure significantly enhances local electric field near DSM, positive...

Abstract Cancer detection and inflammation monitoring during photothermal therapy (PTT) enable timely cancer intervention precise control, advancing to address inflammation‐related tumor recurrence metastasis associated with PTT. This can be achieved through real‐time biomarker for inflammation, like hypochlorous acid (HOCl), a highly reactive oxygen species (hROS) in body elevated levels inflammation. Here, HOCl‐responsive theranostic nanoprobe is introduced, AuNRs@SiO 2 ‐CAA ratiometric...

Abstract Rapid and sensitive detection of thrombin is imperative for the early diagnosis, prevention, treatment thrombin‐related diseases. Here, an ultrasensitive rapid biosensor developed based on rationally designed trifunctional protein HTs, comprising three functional units, including a far‐red fluorescent smURFP, hydrophobin HGFI, cleavage site (TCS). smURFP used as signal to eliminate any interference from autofluorescence sample matrix increase sensitivity. HGFI serve adhesive unit...

Tunable optical bistability (OB) plays an active role in the manipulation of switches. Here, by combining graphene with one-dimensional photonic crystal (1D PC) a defect layer, we theoretically design simple multilayer structure to manipulate OB. Through coupling Tamm plasmon (TP) and mode (DM), induced narrow peak can be generated original wide reflection angle, so it presents richer situation The theoretical results show that OB adjusted optimizing Fermi energy, number layers. In addition,...

As one of the most common mycotoxins, deoxynivalenol (DON) can contaminate a wide range crops and foods. Porcine circovirus 2 (PCV2) is kind immunosuppressive virus, which cause porcine associated disease (PCVD) in pig farms infected with PCV2. Pigs are extremely sensitive to DON, PCV2-infected often contaminated DON. Our previous studies indicated that Bacillus amyloliquefaciens B10 (B10) has potential alleviate toxicity mycotoxins. The research was aimed at investigating effects on caused...

In this paper, we study the nonlinear optical bistability (OB) in a symmetrical multilayer structure. This structure is constructed by embedding three-dimensional Dirac semimetal (3D DSM) into Fabry–Perot cavity composed of one-dimensional photonic crystals. The OB phenomenon stems from third order conductivity 3D DSM. local field resonance mode could enhance nonlinearity and reduce thresholds OB. achieves tunability due to fact that transmittance be modulated Fermi energy. It found...

We report the development of a hydroxyl radical responsive nanoprobe based on clay nanoparticles for ratiometric fluorescence determination and imaging macrophage polarization induced by biomolecules ultrasound stimulations.

Dermatomyositis (DM) and muscular dystrophy are clinically difficult to differentiate.To confirm the feasibility assess accuracy of conventional magnetic resonance imaging (MRI), T2 map, diffusion tensor (DTI), kurtosis (DKI) in differentiation DM from dystrophy.Forty-two patients with proven by diagnostic criteria were enrolled study along 23 dystrophy. Conventional MR, DTI, DKI images obtained thigh musculature for all patients. Intramuscular value, apparent coefficient (ADC), fractional...

Maintenance chemotherapeutic regimen with low toxicity is needed for metastatic colorectal cancer. A recent patent has been issued on the spleen-strengthening and detoxification prescription (JPJDF), a traditional Chinese herbal medicinal formula anti-angiogenesis effect. The clinical effect of JPJDF maintenance treatment advanced cancer not evaluated.This study aims to evaluate effectiveness safety in combination fluoropyrimidine compared alone as therapy cancer.We applied prospective,...

In this paper, we theoretically study the optical bistability (OB) of reflected beams in a composite multilayer structure with three-dimensional Dirac semimetals (3D DSMs) and one-dimensional photonic crystal (1D PC) on both sides spacer layer. The Tamm states (OTSs) excited by 3D DSMs-1D PC significantly enhances local electric field near nonlinear DSMs, which provides positive condition for realization low threshold OB. Through parameter optimization, obtain an incident 106 V/m levels....

Deoxynivalenol (DON) is a common type B trichothecene mycotoxin. Exposure to DON induces kidney damage in humans and animals. Porcine circovirus 2 (PCV2) the main pathogen causing porcine associated disease (PCVD) swine farms, its target organ mainly kidney. Pigs are extremely sensitive DON, farms infected with PCV2 often contamination. The widespread use of antibiotics has made some pathogenic microorganisms resistant, probiotics considered one best alternatives antibiotics....

Abstract Background The study of microRNAs (miRNAs) is attracting great considerations. Recent studies revealed that miRNAs play as important regulators gene expression and some even cancer players or inhibitors. Many try to discover new reveal the miRNA profile in using a SAGE-based total RNA clone method. However, data processing this method labor-intensive with several different biological databases more than ten steps involved. Results With miRAS, possible candidates contained submitted...

In article number 2000364 by Yanyan Wang, Zefang and co-workers, an ultrasensitive rapid thrombin biosensor is developed based on rationally designed trifunctional protein HTs, comprising three functional units, including a far-red fluorescent smURFP, hydrophobin HGFI, cleavage site (TCS). smURFP used as detection signal to eliminate any interference from the autofluorescence of sample matrix increase sensitivity. HGFI serves adhesive unit allow immobilization HTs multiwall plate. The TCS...

In this work, we theoretically investigate the superluminal and subluminal reflected group delay from an air-Weyl semimetal film-Weyl substrate layered structure by using 4*4 magneto-optical matrix. We show a tunable transition between positive negative delays of reflection pulse in such controlled properties Weyl Semimetal layer reveal its mechanism to control propagation light structure. It is demonstrated that are values vice versa, which adjusted tuning incident angle, thickness film,...