A5048020766- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Pituitary Gland Disorders and Treatments
- Ferroptosis and cancer prognosis
- Colorectal Cancer Surgical Treatments
- Adrenal and Paraganglionic Tumors
- TGF-β signaling in diseases
- Diverticular Disease and Complications
- Barrier Structure and Function Studies
- Pancreatic and Hepatic Oncology Research
- Intestinal Malrotation and Obstruction Disorders
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Pediatric Hepatobiliary Diseases and Treatments
- Immune cells in cancer
- Hemodynamic Monitoring and Therapy
- Hernia repair and management
- Genetic factors in colorectal cancer
- Gallbladder and Bile Duct Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Surgical site infection prevention
- Epigenetics and DNA Methylation
- Injury Epidemiology and Prevention
Vanderbilt University Medical Center
2021-2024
Monroe Carell Jr. Children's Hospital
2021-2023
Meharry Medical College
2021-2022
Vanderbilt University
2021-2022
American College of Surgeons
2022
Allegheny Health Network
2022
Abstract Papillary thyroid carcinoma (PTC) demonstrates significantly reduced patient survival with metastatic progression. Tumor progression can be influenced by metabolism, including antioxidant glutathione (GSH). Glutathione peroxidase 4 (GPX4) is a selenoenzyme that uses GSH as co-factor to regulate lipid peroxidation of cell membranes during increased oxidative stress. GPX4 suppression in tumor cells induce ferroptosis. This study aims examine ferroptosis potentially critical pathway...
Defective barrier function is a predisposing factor in inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Although TGFβ signaling defects have been associated with IBD CAC, few studies examined the relationship between intestinal function. Here, we examine role of via SMAD4 modulation colon The Smad4 gene was conditionally deleted intestines adult mice permeability assessed using an vivo 4 kDa FITC-Dextran (FD4) assay. Mouse isolated for expression (RNA-sequencing),...
Objective: To develop a severity-adjusted, hospital-level benchmarking comparative performance report for postoperative organ space infection and antibiotic utilization in children with complicated appendicitis. Background: No data exist to aid hospitals identifying prioritizing opportunities prevention or antimicrobial stewardship Methods: This was multicenter cohort study using NSQIP-Pediatric from 16 participating regional research consortium, augmented obtained through supplemental chart...
The effects of blood transfusions on oncologic outcomes after surgery remain inconclusive. Thus, we examined the association between receiving a perioperative transfusion and in patients undergoing curative rectal cancer resection.The purpose this study was to assess with disease-free overall survival resection clinical stage I III cancer. We hypothesized that is associated worse patient cohort.This retrospective cohort using propensity score-matched analysis.The involved 6 tertiary academic...
Background While cholecystectomy is one of the most common operations performed in United States, there a continued debate regarding its prophylactic role elective surgery. Particularly among patients with peritoneal carcinomatosis who undergo cytoreduction surgery hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), further abdominal may pose increasing morbidity due to intraabdominal adhesions and potential recurrence. This bi-institutional retrospective study aims assess postoperative...
Adrenocortical carcinoma (ACC) is a rare but highly aggressive malignancy. Nearly half of ACC tumours overproduce and secrete adrenal steroids. Excess cortisol secretion, in particular, has been associated with poor prognosis among patients. Furthermore, recent immunotherapy clinical trials have demonstrated significant immunoresistance cortisol-secreting (CS-ACC) patients when compared to their non-cortisol-secreting (nonCS-ACC) counterparts. The immunosuppressive role excess glucocorticoid...
The clinical significance of gangrenous, suppurative, or exudative (GSE) findings is poorly characterized in children with nonperforated appendicitis.To evaluate whether GSE appendicitis are associated increased risk surgical site infections and resource utilization.This multicenter cohort study used data from the Appendectomy Targeted Database American College Surgeons Pediatric National Surgical Quality Improvement Program, which were augmented operative report obtained by supplemental...
Outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) among patients peritoneal carcinomatosis (PC) depend largely on the extent disease. Since PC is not reliably evaluated cross-sectional imaging, tumor burden often diagnostic laparoscopy (DLS). The aims this study are to evaluate safety DLS in disease and determine if delays time CRS-HIPEC.We performed an institutional retrospective review 145 who underwent CRS-HIPEC between 2013 2020. Patients were...
Abstract Background The primary aim of this study is to evaluate the oncologic outcomes two popular systemic chemotherapy approaches in patients with colorectal peritoneal metastases (CPM) undergoing cytoreductive surgery hyperthermic intraperitoneal (CRS‐HIPEC). Methods We performed a dual‐center retrospective review consecutive who underwent CRS‐HIPEC for CPM due high or intermediate‐grade cancer. Patients total neoadjuvant therapy (TNT) group received 6 months preoperative chemotherapy....
To evaluate whether redosing antibiotics within an hour of incision is associated with a reduction in incisional surgical site infection (iSSI) children appendicitis.Existing data remain conflicting as to appendicitis receiving at diagnosis benefit from antibiotic before incision.This was multicenter retrospective cohort study using the Pediatric National Surgical Quality Improvement Program augmented utilization and operative report obtained though supplemental chart review. Children...
Abstract Background & Aims Chronic inflammation in the colon is a predisposing factor for cancer. We previously reported that epithelial cell silencing of Smad4 , central downstream mediator TGFβ family signaling, increased expression inflammatory genes, including chemokine CCL20, and susceptibility to colitis-associated Here, we examine role chemokine/receptor pair CCL20/CCR6 mediating carcinogenesis induced by SMAD4 loss. Methods Mice with conditional, epithelial-specific loss without...
This case details the presentation and surgical management of a 15-year-old male patient with multiple endocrine neoplasia syndrome type 1 (MEN1) who required distal pancreatectomy for nonfunctional pancreatic tumors. An intraoperative ultrasound was utilized to allow proper location pancreatectomy, as well visualization splenic vessel relationships ensure all lesions were contained within specimen. Pathology demonstrated 5 well-differentiated neuroendocrine tumors no evidence malignancy....