A5024080747- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Digestive system and related health
- Metabolism and Genetic Disorders
- LGBTQ Health, Identity, and Policy
- Neuroinflammation and Neurodegeneration Mechanisms
- Clinical Nutrition and Gastroenterology
- Appendicitis Diagnosis and Management
- Infant Development and Preterm Care
- Child Nutrition and Feeding Issues
- Gastrointestinal motility and disorders
- Tendon Structure and Treatment
- Neuroscience and Neuropharmacology Research
- Nerve Injury and Rehabilitation
- Breastfeeding Practices and Influences
- Chemical Synthesis and Reactions
- Child Nutrition and Water Access
- Trace Elements in Health
- Neurogenesis and neuroplasticity mechanisms
- Foot and Ankle Surgery
- Congenital Anomalies and Fetal Surgery
- Diet and metabolism studies
- Epilepsy research and treatment
- Sexual Differentiation and Disorders
- Inorganic and Organometallic Chemistry
Johns Hopkins Medicine
2018-2024
Johns Hopkins University
2018-2024
Johns Hopkins Children's Center
2022-2023
Johns Hopkins Hospital
2022-2023
Children's Hospital of Pittsburgh
2022
University of Pittsburgh
2022
Bloomberg (United States)
2022
Hospital Universitario Puerta de Hierro Majadahonda
2009-2019
Yale University
2018
Hospital San Borja Arriarán
2015
Abstract Background: The objective of the study was to identify national trends in utilization histrelin acetate implants among transgender children United States. Methods: We analyzed demographic, diagnostic and treatment data from 2004 2016 on use reported Pediatric Health Information System (PHIS) determine temporal its for transgender-related billing diagnoses, e.g. “gender identity disorder”. Demographic payer status this patient population were also collected. Results: Between 2016,...
Abstract Two mild new chromium (VI) reagents derived from nicotinic acid and isonicotinic are described. Nicotinium dichromate (NDC) isonicotinium (INDC) oxidize alcohols into carbonyl compounds, mercaptans disulfides hydroquinones quinones. Oxidtion of polynuclear aromatic hydrocarbons is made. Pyridine assisted oxidations by means these also
This study reveals that the administration of human milk oligosaccharides, which are present in breast milk, can interfere with proinflammatory gut-brain axis and prevent neuroinflammation setting necrotizing enterocolitis, a major intestinal disorder seen premature infants.
Rett syndrome (RTT) is a devastating neurodevelopmental disorder affecting 1 in 10,000 girls. Approximately 90% of cases are caused by spontaneous mutations the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). Girls with RTT suffer from severe motor, respiratory, cognitive and social abnomalities attributed to early deficits synaptic connectivity which manifest adult as myriad physiological anatomical abnormalities including, but not limited to, dimished dendritic complexity....
In the developing nervous system synaptic refinement, typified by neuromuscular junction where supernumerary connections are eliminated axon retraction leaving postsynaptic target innervated a single dominant input, critically regulates neuronal circuit formation. Whether such competition-based pruning continues in established circuits of mature animals remains unknown. This question is particularly relevant context adult neurogenesis newborn cells must integrate into preexisting circuits,...
This work provides hope for children who develop NEC, a devastating disease of premature infants that is often fatal, by revealing the secreted product amniotic progenitor cells (called ST266) can prevent or treat NEC in mice, piglet, and “NEC-in-a-dish” models this disease. Mechanistically, ST266 prevented bacterial signaling, detailed transcriptomic analysis revealed effects on gut differentiation, immunity, metabolism. Thus, an secretome may offer novel approaches NEC.
The clinical significance of gangrenous, suppurative, or exudative (GSE) findings is poorly characterized in children with nonperforated appendicitis.To evaluate whether GSE appendicitis are associated increased risk surgical site infections and resource utilization.This multicenter cohort study used data from the Appendectomy Targeted Database American College Surgeons Pediatric National Surgical Quality Improvement Program, which were augmented operative report obtained by supplemental...
Here we describe a case of 15-year-old child with Rett syndrome who presented extreme gastric distension and fatal perforation in the setting long-standing aerophagia pathologic colonization Sarcina ventriculi, rare bacteria implicated perforation. This is first report associated by patient aerophagia. Gastric should be considered intellectually disabled children air swallowing present severe dilation and/or
To evaluate whether redosing antibiotics within an hour of incision is associated with a reduction in incisional surgical site infection (iSSI) children appendicitis.Existing data remain conflicting as to appendicitis receiving at diagnosis benefit from antibiotic before incision.This was multicenter retrospective cohort study using the Pediatric National Surgical Quality Improvement Program augmented utilization and operative report obtained though supplemental chart review. Children...
Gonadotropin-releasing hormone (GnRH) agonists are FDA approved for the treatment of precocious puberty. The therapy consists histrelin acetate (Supprelin), a surgically implanted device, or Lupron injections. In recent years, use these agents has been extended to include off-label children with normally timed Trends in GnRH across U.S. have not previously described literature.We analyzed data on Supprelin and reported Pediatric Health Information System (PHIS) from 2013 2016 determine...
Short bowel syndrome (SBS) leads to severe morbidity and mortality. Intestinal adaptation is crucial in improving outcomes. To understand the human gene pathways associated with adaptation, we perform single-cell transcriptomic analysis of small intestinal organoids explanted from mice experimental SBS. We show that transmembrane ion pathways, specifically transepithelial zinc transport pathway genes SLC39A4 SLC39A5, are upregulated This discovery corroborated by an external dataset, bulk...
Abstract Background The diagnosis of ST-Elevation Myocardial Infarction (STEMI) has traditionally relied on a cardiologist's interpretation an Electrocardiogram (EKG). This cumbersome process is costly, inefficient and out date. Artificial Intelligence (AI) -guided algorithms can provide point-of-care, accurate STEMI that will facilitate management. Purpose To demonstrate the feasibility automated AI-guided EKG analysis for diagnosis. Methods An observational, retrospective, case-control...