A5010360155- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Microbial Metabolic Engineering and Bioproduction
- Genetics, Bioinformatics, and Biomedical Research
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Advanced Proteomics Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Enzyme function and inhibition
- Gout, Hyperuricemia, Uric Acid
- Cell Image Analysis Techniques
- Carbohydrate Chemistry and Synthesis
- vaccines and immunoinformatics approaches
- Glycosylation and Glycoproteins Research
- Biochemical effects in animals
European Bioinformatics Institute
2020-2025
Wellcome Trust
2024
The IntAct molecular interaction database (https://www.ebi.ac.uk/intact) is a curated resource of interactions, derived from the scientific literature and direct data depositions. As August 2021, provides more than one million binary by twelve global partners International Molecular Exchange consortium, for which shared curation dissemination platform. IMEx policy has always emphasised fine-grained model, aiming to capture relevant experimental detail essential interpretation provided data....
The Complex Portal (www.ebi.ac.uk/complexportal) is a manually curated, encyclopaedic database of macromolecular complexes with known function from range model organisms. It summarizes complex composition, topology and along links to large domain-specific resources (i.e. wwPDB, EMDB Reactome). Since the last update in 2019, we have produced first draft complexome for Escherichia coli, maintained updated that Saccharomyces cerevisiae, added over 40 coronavirus increased human 1100 include...
Abstract The current coronavirus disease of 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome (SARS-CoV)-2, has spurred a wave research nearly unprecedented scale. Among different strategies that are being used to understand and develop effective treatments, study physical molecular interactions can provide fine-grained resolution mechanisms behind virus biology human organism response. We present curated dataset focused on proteins from SARS-CoV-2, SARS-CoV-1 other...
Abstract Proteins that interact together participate in the same cellular process and influence organismal traits. Despite progress mapping protein-protein interactions we lack knowledge of how they differ between tissues. Due to coordinated (post)transcriptional control, protein complex members have highly correlated abundances are predictive functional association. Here, compiled 7873 proteomic samples measuring levels 11 human tissues use these define an atlas with tissue-specific...
Abstract Dynamic changes in protein glycosylation impact human health and disease progression. However, current resources that capture phenotype information focus primarily on the macromolecules within central dogma of molecular biology (DNA, RNA, proteins). To gain a better understanding organisms, there is need to functional glycans biological processes. A workshop titled “Functional their curation” was held conjunction with 16th Annual International Biocuration Conference discuss ongoing...
Abstract The International Molecular Exchange Consortium (IMEx) has evolved into a vital partnership of open resources dedicated to curating molecular interaction data from the scientific literature. This consortium, which includes IntAct, MINT, MatrixDB, and DIP, is collaborative effort with central mission aggregating detailed experimental evidence in machine‐readable format, supported by controlled vocabularies standard ontologies. IntAct database ( www.ebi.ac.uk/intact ), as an IMEx...
Abstract The Complex Portal (www.ebi.ac.uk/complexportal) is a manually curated reference database for molecular complexes. It unifying web resource linking aggregated data on composition, topology and the function of macromolecular complexes from 28 species. In addition to significantly extending number complexes, we have massively extended coverage human complexome through incorporation high confidence assemblies predicted by machine-learning algorithms trained large-scale experimental...
Abstract The current Coronavirus Disease 2019 (COVID-19) pandemic, caused by the Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), has spurred a wave of research nearly unprecedented scale. Among different strategies that are being used to understand disease and develop effective treatments, study physical molecular interactions enables studying fine-grained resolution mechanisms behind virus biology human organism response. Here we present curated dataset interactions, manually extracted...
Abstract In recent years, a huge amount of data on ncRNA interactions has been described in scientific papers and databases. Although considerable effort made to annotate the available knowledge public repositories, there are still significant discrepancies how different resources capture interpret functional physical associations. present paper, we collection microRNA–mRNA annotated from literature following recognized standard criteria focused microRNAs, which regulate genes associated...
Gout is a painful arthritis that paralyzes human being form period of time; it’s global disease emerging due to life-style change. Many drugs are available but they fail suppress the inflammation and pain quickly lack knowledge about molecules which indirectly interact with each other take part in pathogenesis gout. Relationship between molecular interaction network topology their function has been one major challenges developing novel therapy; hence analysis provides an effective way...
Abstract In recent years, a huge amount of data on ncRNA interactions has been described in scientific papers and databases. Although considerable effort made to annotate the available knowledge public repositories, there are still significant discrepancies how different resources capture interpret ncRNAs functional physical associations. present paper, we have focused microRNAs which regulate genes associated with rare diseases, as case study investigate availability. The list...