A5029508936- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bacterial Identification and Susceptibility Testing
- Chemical Synthesis and Analysis
- Computational Drug Discovery Methods
- Oral microbiology and periodontitis research
- Biochemical and Molecular Research
- Genomics and Phylogenetic Studies
- Mycobacterium research and diagnosis
- Carbohydrate Chemistry and Synthesis
- Bacteriophages and microbial interactions
- Glycosylation and Glycoproteins Research
- Antibiotics Pharmacokinetics and Efficacy
- Click Chemistry and Applications
- Photochromic and Fluorescence Chemistry
- Cancer therapeutics and mechanisms
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Bacterial Genetics and Biotechnology
Canada's Michael Smith Genome Sciences Centre
2024
University of British Columbia
2024
McMaster University
2018-2023
Brock University
2014-2018
Canadian Sleep Society
2018
The Comprehensive Antibiotic Resistance Database (CARD; https://card.mcmaster.ca) is a curated resource providing reference DNA and protein sequences, detection models bioinformatics tools on the molecular basis of bacterial antimicrobial resistance (AMR). CARD focuses high-quality data sequences within controlled vocabulary, Ontology (ARO), designed by biocuration team to integrate with software development efforts for resistome analysis prediction, such as CARD's Gene Identifier (RGI)...
Abstract The Comprehensive Antibiotic Resistance Database (CARD; card.mcmaster.ca) combines the Ontology (ARO) with curated AMR gene (ARG) sequences and resistance-conferring mutations to provide an informatics framework for annotation interpretation of resistomes. As version 3.2.4, CARD encompasses 6627 ontology terms, 5010 reference sequences, 1933 mutations, 3004 publications, 5057 detection models that can be used by accompanying Gene Identifier (RGI) software annotate genomic or...
Plazomicin is a next-generation, semisynthetic aminoglycoside antibiotic currently under development for the treatment of infections due to multidrug-resistant Enterobacteriaceae. The compound was designed by chemical modification natural product sisomicin provide protection from common modifying enzymes that chemically alter these drugs via N-acetylation, O-adenylylation, or O-phosphorylation. In this study, plazomicin profiled against panel isogenic strains Escherichia coli individually...
Apramycin is an aminoglycoside antibiotic that has been traditionally used in veterinary medicine. Recently, it become attractive candidate to repurpose the fight against multidrug-resistant pathogens prioritized by World Health Organization.
Abstract Dynamic changes in protein glycosylation impact human health and disease progression. However, current resources that capture phenotype information focus primarily on the macromolecules within central dogma of molecular biology (DNA, RNA, proteins). To gain a better understanding organisms, there is need to functional glycans biological processes. A workshop titled “Functional their curation” was held conjunction with 16th Annual International Biocuration Conference discuss ongoing...
The reproducibility of bacterial biofilm assays is improved using abrasively-treated microtiter plates.
The environmental microbiome harbors a vast repertoire of antibiotic resistance genes (ARGs) which can serve as evolutionary predecessors for ARGs found in pathogenic bacteria, or be directly mobilized to pathogens the presence selection pressures. Thus, from benign bacteria are an important resource understanding clinically relevant resistance. Here, we conduct comprehensive functional analysis Antibiotic_NAT family aminoglycoside acetyltransferases. We determined pan-family antibiogram 21...
ABSTRACT The environmental microbiome harbors a vast repertoire of antibiotic resistance genes (ARGs) which can serve as evolutionary predecessors for ARGs found in pathogenic bacteria, or be directly mobilized to pathogens the presence selection pressures. Thus, from benign bacteria are an important resource understanding clinically relevant resistance. Here, we conduct comprehensive functional analysis Antibiotic_NAT family aminoglycoside acetyltransferases. We determined pan-family...