A5100646657- Parasitic Infections and Diagnostics
- Insect and Pesticide Research
- Plant and Fungal Interactions Research
- Plant Virus Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Insect symbiosis and bacterial influences
- Plant Disease Resistance and Genetics
- Winter Sports Injuries and Performance
- Sports, Gender, and Society
- Vector-borne infectious diseases
- Chromosomal and Genetic Variations
- Estrogen and related hormone effects
- Nuclear Receptors and Signaling
- Renal cell carcinoma treatment
- Insect Resistance and Genetics
- Physical Activity and Education Research
- CRISPR and Genetic Engineering
- Immune responses and vaccinations
- Consumer Retail Behavior Studies
- Animal Virus Infections Studies
- Metabolomics and Mass Spectrometry Studies
- Single-cell and spatial transcriptomics
- Martial Arts: Techniques, Psychology, and Education
- PARP inhibition in cancer therapy
- Coccidia and coccidiosis research
Capital Medical University
2024
Jinzhou Medical University
2024
Jinan University
2023
Zhejiang Chinese Medical University
2023
Sichuan Cancer Hospital
2023
Southwest University
2004-2021
State Key Laboratory of Silkworm Genomic Biology
2016-2021
Resonance Research (United States)
2019
Mayo Clinic
2019
Chongqing Normal University
2015
Resistance to chimeric antigen receptor (CAR) T-cell therapy remains a significant challenge in the treatment of solid tumors. This resistance is attributed various factors, including loss, immunosuppressive tumor microenvironment, and upregulated checkpoint molecules. Indoleamine 2,3-dioxygenase 1 (IDO1) an enzyme that promotes immune escape In this study, we investigated role ARID5A (AT-rich interactive domain 5A) CAR-T cell therapy. Our findings revealed upregulation cells induces T...
Microsporidia are obligate intracellular parasites that infect a wide variety of host organisms, including humans. The sporoplasm is the initial stage microsporidian infection and proliferation, but its morphological molecular characteristics poorly understood. In this study, Nosema bombycis was successfully isolated characterized after induction spore germination in vitro spherical, 3.64 ± 0.41 μm diameter, had typical two nuclei, nonrefractive. Scanning transmission electron microscopy...
Diabetic kidney disease (DKD) is the most common microvascular complication of diabetes, and there an urgent need to discover reliable biomarkers for early diagnosis.Here, we established effective urine multi-omics platform integrated metabolomics peptidomics investigate biological changes during DKD pathogenesis.Methods: Totally 766 volunteers (221 HC, 198 T2DM, 175 DKD, 125 overt 47 grey-zone T2DM patients with abnormal urinary mALB concentration) were included in this study.Non-targeted...
The Pasteurella multocida capsular type A isolates can cause pneumonia and bovine respiratory disease (BRD). In this study, comparative genomics analysis was carried out to identify the virulence genes in two different virulent P. (high PmCQ2 low PmCQ6). draft genome sequence of is 2.32 Mbp contains 2,002 protein-coding genes, 9 insertion (IS) elements, 1 prophage region. PmCQ6 2.29 1,970 2 IS 3 regions. alignment revealed that similarity between 99% with high colinearity. To candidate...
The dual roles of baculovirus for the control natural insect populations as an insecticide, and a tool foreign gene expression delivery, have called comprehensive understanding molecular mechanisms governing viral infection. Here, we demonstrate that Bombyx mori Niemann-Pick C1 (BmNPC1) is essential infection in cells. Both pretreatment B. embryonic cells (BmE) with NPC1 antagonists (imipramine or U18666A) down-regulation resulted significant reduction BmNPV (B. nuclear polyhedrosis virus)...
The microsporidian parasite designated here as Nosema sp. Isolate YNPr was isolated from the cabbage butterfly Pieris rapae collected in Honghe Prefecture, Yunnan Province, China. genome sequenced by Illumina sequencing and compared to those of two related members Nosema/Vairimorpha clade, ceranae apis. Based upon assembly statistics, is 3.36 x 106bp with a G+C content 23.18% 2,075 protein coding sequences. An "ACCCTT" motif present approximately 50-bp upstream start codon, reported other...
Abstract Nuclear receptors are ubiquitous eukaryotic ligand‐activated transcription factors that modulate gene expression through varied interactions. However, the highly conserved functional sites known today seem insufficient to explain receptor specific recruitment of different coactivator and corepressor proteins regulation transcription. To search for new receptor‐subtype sites, we applied difference evolutionary trace (difference ET) analysis ligand binding domain steroid receptors, a...
RRM2 is the catalytic subunit of ribonucleotide reductase (RNR), which catalyzes de novo synthesis deoxyribonucleotide triphosphates (dNTPs) and plays critical roles in cancer cell proliferation. protein level controlled by ubiquitination mediated degradation system; however, its deubiquitinase has not been identified yet. Here we showed that ubiquitin-specific peptidase 12 (USP12) directly interacts with deubiquitinates non-small lung (NSCLC) cells. Knockdown USP12 causes DNA replication...
Miniature inverted-repeat transposable elements (MITEs) are short, non-autonomous DNA transposons, which widespread in most eukaryotic genomes. However, genome-wide identification, origin and evolution of MITEs remain largely obscure microsporidia. In this study, we investigated structural features for de novo identification genomes silkworm microsporidia Nosema bombycis antheraeae, as well a honeybee ceranae. A total 1490, 149 83 MITE-related sequences from 89, 17 five families,...
To understand the complex nature of atherogenic response initiated by oxidative stress in vascular smooth muscle cells (vSMCs), computational prediction methodology was employed to define putative gene-gene and gene-environment interactions vSMCs subjected chemical stress. Computational relationships were derived from global gene expression profiles murine challenged with a pro-oxidant cause or treated anti-oxidant prior injury. Target clones chosen based on their biological relevance within...
This laboratory previously identified an albumin-like protein (denoted as p70) a component of the macromolecular complex assembled within 5′-regulatory region redox-sensitive genes in vascular smooth muscle cells (vSMCs). Here we show that p70 is present cytosolic and nuclear compartments vSMCs dynamically responsive to redox status. Intense cytoplasmic perinuclear staining, coupled with enhanced localization, was observed vSMCs, but not HepG2 cells, treated benzo(a)pyrene (BaP), H 2 O , or...