A5102893490- Diabetes Treatment and Management
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Genetic Syndromes and Imprinting
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Healthcare and Venom Research
- Acute Myocardial Infarction Research
- Neurological Disorders and Treatments
- Advanced Glycation End Products research
- Biochemical effects in animals
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic function and diabetes
- Ovarian function and disorders
- Thyroid Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Reproductive Biology and Fertility
- Plant-based Medicinal Research
- Tumors and Oncological Cases
- Lipid metabolism and disorders
- Bone health and osteoporosis research
- Cardiac Health and Mental Health
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Sclerosis and Related Diseases
- TGF-β signaling in diseases
- Biochemical Acid Research Studies
Shandong Provincial Hospital
2017-2023
Shandong First Medical University
2020-2023
Shandong Center for Disease Control and Prevention
2023
Shandong Academy of Chinese Medicine
2020
Shandong University
2017
Bile acids have underlying protective effects on bones structure. Long-term diabetes also causes skeletal disorders including osteoporosis, Charcot arthropathy and renal osteodystrophy. Nevertheless, few studies reported whether bile acid is associated with bone metabolism in diabetics. This study aimed to explore the relationship between total (TBA) mineral density (BMD) among patients type 2 mellitus (T2DM). We retrospectively included 1,701 T2DM who were hospitalized Taian City Central...
Idiopathic pulmonary fibrosis (IPF) is a type of scarring lung disease characterized by chronic, progressive, and irreversible decline in function. The genetic basis IPF remains elusive. A transcriptome-wide association study (TWAS) was performed FUSION using gene expression weights three tissues combined with large-scale genome-wide (GWAS) dataset, totally involving 2,668 cases 8,591 controls. Significant genes identified TWAS were then subjected to ontology (GO) pathway enrichment...
Studies indicate a relationship between high-fat diet (HFD) and sperm quality. However, the time-dependent adverse effects of HFD on parameters underlying mechanisms remain unclear.The present study was designed to determine quality at various time points in order assess whether causes cumulative damage sperm.Male C57BL/6 mice were fed normal (the ND group) or for 16, 30 42 weeks (n = 6 each group). Body weight, lipid profile, parameters, testicular morphology, oxidative stress levels...
The Schaaf-Yang syndrome (SYS) is an autosomal dominant multi-system genetic disease caused by melanoma antigen L2 (MAGEL2) gene mutations imprinted mothers and expressed fathers on the 15q11-15q13 chromosomes in critical region of Prader-Willi. MAGEL2 a single exon one protein-coding genes Prader-Willi domain. matrilineal (i.e., maternal chromosome methylated). It only unmethylated paternal alleles, individual affected when variation occurs allele.We reported patient with new site mutation...
Abstract Aims/hypothesis Glucagon-like peptide 1 receptor agonists (GLP-1 RA) such as exenatide are used monotherapy and add-on therapy for maintaining glycaemic control in patients with type 2 diabetes mellitus. The current study investigated the safety efficacy of once-weekly PB-119, a PEGylated injection, treatment-naive diabetes. Methods In this Phase II, randomised, placebo-controlled, double-blind study, we randomly assigned Chinese 1:1:1:1 ratio to receive subcutaneous placebo or one...
Abstract Background Continuous glucose monitoring (CGM) can help manage diabetes mellitus (DM) and prevent hypoglycemia. This study aimed to evaluate the performance usability of a novel SiJoy GS1 CGM system. Methods multicenter trial enrolled participants with DM. Based on comparison values measured by venous blood test, 20/20% consistency mean absolute relative difference (MARD%) were calculated, as well Clarke consensus error grid analysis. Product was evaluated questionnaire completed...
Diabetic nephropathy (DN) causes high mortality in patients with diabetes mellitus and imposes heavy burden on individuals society. In previous studies, various researches have investigated the association of DN CCR5 59029G/A polymorphism, but relevant findings were controversial. Therefore, we performed this meta-analysis to obtain a conclusion issue.CCR5 polymorphism showed significant risk-increasing effects all analyses under AA vs. GG, AA+GA GG+GA, A G GA GG model contrasts. Besides,...
Objective To investigate the characteristics and risk factors causing liver dysfunction for patients with thyroid associated ophthalmopathy(TAO). Methods The TAO terated methylprednisolone were selected from Jan 2010 to Oct 2014. The clinical data retrospectively studied compared between groups normal hepatic function before after treatment. of was identified using Logistics regression analysis. Results A total 153 treated included. incidence 34.6% (53 cases). Increased ALT, GGT...
Objective To observe the efficacy and safety of α-lipoic acid(ALA) on diabetic peripheral neuropathy(DPN). Methods All 284 type 2 inpatients with DPN in sixteen hospitals were selected from August 2009 to March 2010. The patients received ALA 600 mg/d 250 ml normal saline by intravenous drip infusion once a day for 10-14 days. Before after management, total symptom score(TSS) was used evaluate nervous symptoms, including numbness, sting sensation, burning sensation hypoesthesia.The...
Abstract Background: Superoxide dismutase (SOD) and inflammatory markers are reported to have association with cardiovascular disease. However, no previous study has assessed the value of SOD as predictive indicator heart failure in patients diabetes acute coronary syndrome (ACS) same study. Objective: The objective this is compare implications activity, C-reactive protein (CRP) fibrinogen for reduced left ventricular ejection fraction (LVEF) ACS. Method: included 2377 inpatients type 2 who...