A5036733696- Flavonoids in Medical Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Remote Sensing in Agriculture
- Neurological Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Land Use and Ecosystem Services
- Traditional Chinese Medicine Analysis
- Renal cell carcinoma treatment
- Remote Sensing and Land Use
- Lung Cancer Research Studies
- Natural product bioactivities and synthesis
- Diet and metabolism studies
- Neuroendocrine Tumor Research Advances
- Acute Ischemic Stroke Management
- Neurological disorders and treatments
- Cancer Immunotherapy and Biomarkers
- Plant-based Medicinal Research
- Coastal and Marine Management
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Blood Coagulation and Thrombosis Mechanisms
- Alzheimer's disease research and treatments
- Calpain Protease Function and Regulation
- Bioactive natural compounds
- RNA regulation and disease
Second Hospital of Shandong University
2007-2025
Shandong University
2013-2025
Sun Yat-sen University
2025
Shaoxing People's Hospital
2024
Zhejiang Chinese Medical University
2023
Institute of Agricultural Resources and Regional Planning
2007-2019
Chinese Academy of Agricultural Sciences
2007-2019
Daqing Oilfield General Hospital
2006
Shandong University of Traditional Chinese Medicine
2004-2005
Long non-coding RNA (lncRNA) and exosomes are involved in the pathological process of Alzheimer's disease (AD), changes which usually first observed entorhinal cortex hippocampus. The aim present study was to determine whether measurement plasma exosomal lncRNA combined with image data hippocampus could be used as a biomarker AD. A total 72 patients AD 62 controls were recruited, expression levels several lncRNAs assessed. Of recruited participants, 22 26 received brain 3D‑BRAVO sequence...
Baicalin is a flavonoid compound purified from the roots of Scutellaria baicalensis, which possesses multiple biological activities. Previous studies have shown that baicalin protective in ischemic cerebral diseases. The aim present study was to examine effects on brain injury rat model intracerebral hemorrhage (ICH) and explore possible mechanisms. Intracerebral induced male Wistar rats by injection 0.5 U collagenaseVII caudate nucleus. Sham operation were injected with equal volume saline....
The Omicron subvariants of SARS-CoV-2 spread rapidly since 2021. Following China's relaxation containment measures in December 2022, a surge COVID-19 cases poses public health threat. Early identification elderly patients at death risk is crucial for optimizing treatment and resource use. To develop clinical score predicting hospital admission, based on cohort from the Second Hospital Shandong University. We established retrospective hospitalized November 1, to March 31, 2023. Cox regression...
Abstract Chemotherapy resistance in colorectal cancer (CRC) remains a major obstacle clinical oncology. Analysis of specimens from chemotherapy-resistant patients revealed elevated CXCL7 expression tumor-associated macrophages (TAMs). Through integrated vitro and vivo studies, we demonstrated that chemotherapy induces tumor cell-macrophage crosstalk, leading to upregulation TAMs. Using co-culture system, observed CXCL7+ confer chemoresistance CRC cells. Mechanistic investigations activates...
ObjectiveClear cell renal carcinoma (ccRCC) is the most common subtype among carcinomas and has worst prognosis, originating from tubular epithelial cells. Toll-like receptor 4 (TLR4) plays a crucial role in ccRCC proliferation, infiltration, metastasis. The aim of this study was to construct prognostic scoring model for based on TLR4 expression heterogeneity explore its association with immune thereby providing insights treatment evaluation ccRCC.MethodsUsing R software, differential...
Abstract Background Palliative care and the integration of health social have gradually become key direction development to address aging population growing burden multimorbidity at end life in elderly. Aims To explore benefits/effectiveness availability stability palliative for family members terminally ill patients an integrated institution care. Methods This prospective observational study was conducted 230 with terminal illness who received their were included. Questionnaires scales...
Abstract We explored the effect of thrombin on human aortic smooth muscle cells (HASMCs) and further analyzed its role in pathogenesis atherosclerosis (AS). Thrombin-induced differentially expressed genes (DEGs) HASMCs were identified by analyzing expression profiles from GEO. Subsequently, enrichment analysis, GSEA, PPI network, gene-microRNAs networks interrogated to identify hub associated pathways. Enrichment analysis results indicated that causes secrete various pro-inflammatory...
Thrombin plays a pivotal role in the pathogenesis of atherosclerosis. Baicalin, an active flavonoid compound, was shown to attenuate development atherosclerosis, but mechanism remains elusive. In present study, and baicalin thrombin-induced cell injury investigated human umbilical vein endothelial cells (HUVECs). Our results showed that significantly reduced apoptosis HUVECs. Additional experiments inhibited NF-κB activation PAR-1 expression. addition, decreased expression by inhibiting ERK...
Atherosclerosis (AS) is a chronic inflammatory disease of the arterial intima. As AS represents most common type vascular disease, it affects millions individuals and source high morbidity mortality rates worldwide. Overwhelming evidence indicates that AS-related inflammation mediated by proinflammatory cytokines, chemokines, adhesion molecules signaling pathways, with each these factors being shown to play critical roles during entire progression AS. While number drugs have been approved...
"Baicalin, a major flavonoid compound isolated from the dry roots of Scutellaria baicalensis Georgi, has been shown to be neuroprotective after ischemic brain injury. However, little is known about its effects on injury following intracerebral hemorrhage (ICH). In this study, we evaluated baicalin ICH-induced in an ICH rat model. Male Wistar rats were injected intracerebrally with 0.5 U collagenaseVII induce ICH, while control equal volume saline. After induction, randomly divided into four...
BackgroundIt is important to explore novel molecules that play a key role in esophageal cancer (ESCA) progression.MethodsTwo ESCA tissue expression profile microarrays (GSE92396 and GSE17351) data from GEO were downloaded, differentially expressed genes (DEGs) analyzed using GEO2R. The DEGs common both for protein-protein interactions, KEGG GO. altered of proteasome 20S subunit α 7 (PSMA7) tissues was information publicly available databases (GEO, TCGA, TNMplot). PSMA7 overexpressed or...
In this study, we initially classified renal cell carcinoma (ccRCC) samples into three distinct clusters based on immune expression patterns, utilizing an analysis of immunomodulatory genes. Through comprehensive examination the differential genes across these clusters, a prognostic risk assessment framework was developed, aimed at determining levels to assist in evaluation and targeted therapy for ccRCC patients. Employing consensus clustering method, 435 shared were pinpointed,...
This study aims to examine the suitability of Globcover land cover dataset for its accuracy in mapping and monitoring cropland Northeast China three provinces. To do so, was compared with reference national 2000 (NLCD-2000) assessing aggregated area spatial extent across area. The results showed that Jilin province is higher than other two Regions relatively are mainly distributed central west part area, whereas low exists at east south coastal coarse resolution per pixel classification...
Previous observational studies have suggested a notably elevated prevalence of delirium in individuals diagnosed with Parkinson's disease (PD), thereby implying potential increased susceptibility to among PD patients. However, it is imperative acknowledge that inherently possess limitations, rendering arduous establish definitive causal or reverse association between and PD. To explore the relationship PD, bidirectional two-sample Mendelian randomization (MR) was conducted using summary...
The purpose of this article is to study the immune microenvironment characteristics renal clear cell tumor and application effect immunotherapy in tumor. In order achieve goal, adopts systematic experimental methods analytical means. Firstly, distribution infiltrating cells expression key molecules were described detail by collecting samples using flow cytometry, immunohistochemistry other technical Subsequently, vitro vivo experiments designed implemented evaluate anti-tumor effects...
Anemia, characterized by low hemoglobin or erythrocyte levels, is a significant global health issue with severe implications for public health. Recent studies have explored the potential link between anemia and 25-hydroxyvitamin D [25(OH)D], yet precise mechanisms remain unclear. This study aims to clarify possible causal relationship 25(OH)D levels risk.