A5029752975- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Acute Myocardial Infarction Research
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic Disease and Treatment Approaches
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Acute Ischemic Stroke Management
- Cardiac Health and Mental Health
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Disease and Adiposity
- Cardiovascular Issues in Pregnancy
- Medication Adherence and Compliance
- Cardiovascular Effects of Exercise
Vanderbilt University Medical Center
2022-2025
Twitter (United States)
2024
Clinical Research Institute
2017-2022
Duke University
2018-2022
Duke Medical Center
2017-2022
Vanderbilt University
2022
Duke University Hospital
2020
North Carolina Central University
2020
Emory University
2018
Previous studies have reported worse outcomes in women following percutaneous coronary intervention (PCI), but contemporary examining sex differences in-hospital and 90-day readmission risk are lacking. Therefore, we sought to compare rates adverse after PCI. We used the United States National Readmissions Database stratify all inpatient PCIs from 2017 2018 by sex. then performed propensity score matching of two groups based on demographics, medical history, hospital characteristics,...
Background Aortic valve replacement (AVR) is a life‐saving treatment for patients with symptomatic severe aortic stenosis. We sought to determine whether transcatheter AVR has resulted in more equitable rate by race the United States. Methods and Results A total of 32 853 stenosis were retrospectively identified via Optum’s deidentified electronic health records database (2007–2017). rates non‐Hispanic Black White assessed year after diagnosis. Multivariate Fine‐Gray hazards models used...
As the population ages, older adults represent an increasing proportion of patients referred to cardiac catheterization laboratory. Older are highest-risk group for morbidity and mortality, particularly after complex, high-risk percutaneous coronary interventions. Structured risk assessment plays a key role in differentiating who likely derive net benefit vs those have disproportionate risks harm. Conventional tools from national cardiovascular societies typically rely on 3 pillars: 1) risk;...
Background: Palliative care improves quality of life in patients with heart failure. Whether men and women failure derive similar benefit from palliative interventions remains unknown. Methods: In a secondary analysis the PAL-HF trial (Palliative Care Heart Failure), we analyzed differences among assessed for differential effects intervention by sex. Differences clinical characteristics quality-of-life metrics were compared between at serial time points. The primary outcome was change Kansas...
Background Knowledge is scarce regarding how multimorbidity associated with therapeutic decisions oral anticoagulants (OACs) in patients atrial fibrillation. Methods and Results We conducted a cross-sectional study of hospitalized fibrillation using the Get With The Guidelines-Atrial Fibrillation registry from 2013 to 2019. identified ≥65 years eligible for OAC therapy. Using 16 available comorbidity categories, were stratified by morbidity burden. A multivariable logistic regression model...
Although cardiovascular (CV) disease represents the leading cause of morbidity and mortality that increases with age, best noninvasive test to identify older patients at risk for CV events remains unknown.To determine whether prognostic utility anatomic vs functional testing varies based on patient age.Prespecified analysis Prospective Multicenter Imaging Study Evaluation Chest Pain (PROMISE) study, which used a pragmatic comparative effectiveness design. Participants were enrolled from 193...
We review a comprehensive risk assessment approach for percutaneous coronary interventions in older adults and highlight the relevance of geriatric syndromes within that broader perspective to optimize patient-centered outcomes interventional cardiology practice. Reflecting influence principles undergoing interventions, we propose "geriatric" heart team incorporate expertise specialists addition traditional members, facilitate uptake into preprocedural assessment, address ways mitigate these...
We evaluated whether there is equitable distribution across sexes of treatment and outcomes for aortic valve replacement (AVR), via surgical (SAVR) or transcatheter (TAVR) methods, in symptomatic severe stenosis (ssAS) patients. Using de-identified data, we identified 43,822 patients with ssAS (2008-2016). Multivariate competing risk models were used to determine the likelihood any AVR, while accounting death. Association between sex 1-year mortality, stratified by AVR status, was using...
Background: Clinical event committees are commonly employed for validation in clinical studies, but little is known about the comparative performance of administrative claims data versus clinician-triggered adjudication ascertainment adverse events structural heart disease studies. Methods and Results: Medicare were linked to 418 patients >65 years age who underwent transcatheter mitral valve repair (MitraClip) severe regurgitation from 2007 2013 as part EVEREST II (Endovascular Valve...
Randomized clinical trials have demonstrated that catheter ablation for atrial fibrillation in patients with heart failure reduced ejection fraction may improve survival and other cardiovascular outcomes.We constructed a decision-analytic Markov model to estimate the costs benefits of medical management symptomatic (left ventricular ≤35%) over lifetime horizon. Evidence from published literature informed inputs, including effectiveness data meta-analyses. Probabilistic deterministic...
Background: The relationship between body size and cardiovascular events is complex. This study utilized the ADVANCE (Assessing Diagnostic Value of Noninvasive FFR CT in Coronary Care) Registry to investigate association mass index (BMI), coronary artery disease (CAD), clinical outcomes. Methods: registry enrolled patients undergoing evaluation for clinically suspected CAD who had >30% stenosis on cardiac computed tomography angiography. Patients were stratified by BMI: normal <25 kg/m...