A5074535270- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Cassava research and cyanide
- Genomics and Phylogenetic Studies
- Retinal Diseases and Treatments
- Advanced Glycation End Products research
- Plant Parasitism and Resistance
- Extracellular vesicles in disease
- Ecology and Vegetation Dynamics Studies
- Plant Micronutrient Interactions and Effects
- Traumatic Ocular and Foreign Body Injuries
- Food composition and properties
- HVDC Systems and Fault Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Statistical Process Monitoring
- Genetic and Environmental Crop Studies
- Advanced Multi-Objective Optimization Algorithms
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Inflammasome and immune disorders
- Optimal Experimental Design Methods
- Cancer Immunotherapy and Biomarkers
Nanjing Drum Tower Hospital
2023-2024
Nanjing Agricultural University
2015-2023
Zoucheng People's Hospital
2023
Chinese Academy of Tropical Agricultural Sciences
2016-2017
Tropical Crops Genetic Resources Institute
2016
Arizona State University
2010
Abstract N 6-methyladenosine (m6A), the most prevalent mRNA modification in eukaryotes, is an emerging player of gene regulation at transcriptional and translational levels. Here, we explored role m6A response to low temperature Arabidopsis (Arabidopsis thaliana). Knocking down adenosine methylase A (MTA), a key component complex, by RNA interference (RNAi) led drastically reduced growth temperature, indicating critical chilling response. Cold treatment overall level mRNAs especially 3′...
Abstract Cold tolerance adaption is a crucial determinant for the establishment and expansion of invasive alien plants into new cold environments; however, its evolutionary mechanism poorly understood. Crofton weed ( Ageratina adenophora ), highly plant, continuously spreading across subtropical areas in China, north‐eastward from first colonized south‐western tropical regions, through evolution. Close relations between levels 34 populations, represented by 147 accessions, latitude, extreme...
Abstract Background Direct analogs of chemically modified bases that carry important epigenetic information, such as 5-methylcytosine (m5C)/5-methyldeoxycytosine (5mC), 5-hydroxymethylcytosine (hm5C)/5-hydroxymethyldeoxycytosine (5hmC), and N 6 -methyladenosine (m6A)/ -methyldeoxyadenosine (6mA), are detected in both RNA DNA, respectively. The base 4 -acetylcytosine (ac4C) is well studied RNAs, but its presence roles cellular DNA have not been explored. Results Here, we demonstrate the...
Abstract Purpose This study aimed to investigate the effect of mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) on diabetic retinopathy (DR) and its underlying mechanism. Methods In vivo, MSC-sEVs were injected intravitreally into rats determine therapeutic efficacy. vitro, with/without miR-22-3p inhibition cocultured with advanced glycation end-products (AGEs)-induced microglia NLRP3 overexpression explore molecular Results inhibited inflammasome activation,...
Thermal ablation is the primary procedure for local treatment of lung metastases. It known that radiotherapy and cryoablation can stimulate an abscopal effect, while occurrence effect induced by microwave less; cellular molecular mechanisms involved in after should be further elucidated.CT26 tumor-bearing Balb/c mice were treated with several combinations power time duration. The growth or tumors survival both monitored; moreover, immune profiles tumors, spleens, lymph nodes examined flow...
The remodeling of transcriptome, epigenome, proteome, and metabolome in hybrids plays an important role heterosis. N(6)-methyladenosine (m 6 A) methylation is the most abundant type post-transcriptional modification for mRNAs, but pattern inheritance from parents to potential impact on heterosis are largely unknown. We constructed transcriptome-wide mRNA m A maps Arabidopsis thaliana Col-0 Landsberg erecta (Ler) their reciprocal F 1 hybrids. Generally, tends be conserved between accessions....
Abstract Cassava ( Manihot esculenta Crantz) is an important tropical starchy root crop that adapted to drought but extremely cold sensitive. A cold-tolerant, high-quality, and robust supply of cassava urgently needed. Here, we clarify genome-wide distribution classification CCGG hemi-methylation full-methylation, detected 77 much candidate QTLs epi for stress 103 storage quality yield in 186 population, generated by crossing two non-inbred lines with female parent KU50 male SC124 (KS...
Abstract Aims To explore the application and long-term clinical effects of modified Yamane technique in intrascleral intraocular lens (IOL) fixation combined with or without iris reconstruction. Settings design The data patients receiving IOL an ophthalmology department between December 2021 August 2023 were analyzed retrospectively. longest follow-up duration was > 12 months. Methods material trailing haptic fixed needle before leading haptic. silicone stoppers used to stabilize when...
N6-methyldeoxyadenosine (6mA) is a recently discovered DNA modification involved in regulating plant adaptation to abiotic stresses. However, the mechanisms and changes of 6mA under cold stress plants are not yet fully understood. Here, we conducted genome-wide analysis observed that peaks were predominantly present within gene body regions both normal conditions. In addition, global level increased Arabidopsis rice after treatment. The genes exhibited an up-methylation showed enrichment...
Diabetic retinopathy (DR) is recognized as the most prevalent retinal degenerative disorder. Inflammatory response particularly precedes microvascular alteration, considered primary factor of diabetic retinopathy. Actived microglia express many pro-inflammatory cytokines exacerbates retina inflammation and disruption. In present study, we investigated that MSCs alleviated blood–retina barrier (BRB) breakdown in rats, evidenced by reduced edema, decreased vascular leakage, increased occludin...
Abstract This paper proposes a method to improve the process model estimation based on limited experimental data by making use of abundant production and achieve optimal adjustment improved model. The proposed is called an Estimation‐adjustment (EA) method. Furthermore, this proves three properties associated with EA, which guarantee feasibility effectiveness using EA for integrating adjustment. Also, develops sequential hypothesis testing procedure implementing EA. implementation are...