A5080115100- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Bioactive Compounds and Antitumor Agents
- Retinoids in leukemia and cellular processes
- Cell death mechanisms and regulation
- Eicosanoids and Hypertension Pharmacology
- Morinda citrifolia extract uses
- Synthetic Organic Chemistry Methods
- Metabolism, Diabetes, and Cancer
- Essential Oils and Antimicrobial Activity
- Immune Response and Inflammation
- Hormonal Regulation and Hypertension
- Natural Antidiabetic Agents Studies
- Marine Sponges and Natural Products
- Phytochemistry and Biological Activities
- Metabolomics and Mass Spectrometry Studies
- Cancer Mechanisms and Therapy
- Pharmacological Effects of Natural Compounds
- Medicinal Plant Extracts Effects
- Cytokine Signaling Pathways and Interactions
- Microbial Natural Products and Biosynthesis
- Protein Tyrosine Phosphatases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chromatography in Natural Products
- Molecular spectroscopy and chirality
Chungnam National University
2017-2025
Target (United States)
2022-2024
National Cancer Institute
2022-2024
Center for Cancer Research
2022-2024
National Institute of Nutrition
2016-2019
The aim of the present study was to examine antioxidative activity (+)-lariciresinol (LRSL), an optically active lignan isolated from Rubia philippinensis in several vitro assays. LRSL also subjected evaluate its inhibitory effect against generation reactive oxygen species (ROS) murine macrophage (RAW 264.7) cells. results showed that possessed very strong radical scavenging and reducing power, as well inhibited ROS a dose-dependent manner without showing any cytotoxicity. transcriptional...
Abstract We examined the anti-inflammatory effects of (+)-syringaresinol (SGRS), a lignan isolated from Rubia philippinensis , in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells using enzyme-based immuno assay, Western blotting, and RT-PCR analyses. Additionally, vivo SGRS acute inflammatory state were by carrageenan-induced hind paw edema assay experimental mice. As result, treatment with (25, 50, 100 μM) inhibited protein expression lipopolysaccharide-stimulated inducible nitric oxide...
Scope Momordica charantia (M. charantia) has antidiabetic effects, and cucurbitane‐type triterpenoid is one of the compounds M. . This study aims to investigate whether new triterpenoids affect insulin sensitivity both in vitro vivo, underlying mechanisms. Methods results Four (C1–C4) isolated from ethanol extract enhance glucose uptake C2C12 myotubes via receptor substrate‐1 (IRS‐1) rather than adenosine monophosphate‐activated protein kinase. The most potent, compound 2 (C2), significantly...
Background and Purpose The proliferation migration of vascular smooth muscle cells (VSMCs) induced by platelet‐derived growth factor (PDGF) are important steps in cardiovascular diseases, including neointimal lesion formation, myocardial infarction atherosclerosis. Here, we evaluated the rubiarbonone C‐mediated signalling pathways that regulate PDGF‐induced VSMC migration. Experimental Approach Cell were measured treated with C followed PDGF BB using MTT assay, [ 3 H]‐thymidine...
Cancer is one of the most frequently occurring diseases and second leading cause death worldwide. In this study, anthraquinone derivatives (Compounds 1-5) were evaluated for their anti-cancer potential against various skin breast cancer cell lines to assess whether these may serve as a lead augmentation drug.Anthraquinone derivatives, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-α-rhamnosyl(1 → 2)-β-glucoside (Comp 1), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone 2),...
The abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are associated with cardiovascular diseases related complications. Such deleterious events triggered by cytokines growth factors, among them, platelet-derived factor (PDGF) is recognized as the most potent inducer. Despite genus Rubia being researched to identify valuable commercial medicinal virtues, philippinensis has rarely been investigated. Nine arborinane-type triterpenoids (1–9) were identified from this...
Paratrimerins J–Y (1–13 and 16–18), new dimeric coumarins, were obtained from the EtOH(aq) extract of stems Paramignya trimera (Rutaceae) utilizing LC/MS guided isolation. The structures coumarins elucidated based on 1D/2D NMR spectroscopic HR-ESIMS data analyses. absolute configurations paratrimerins along with those two known dimers A (14) B (15) established basis experimental simulated ECD data. In addition, sugar units A, B, J–V (1–15) confirmed by analysis l-cysteine methyl ester phenyl...
Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous cancer. Two new prenylated indole 2,5-diketopiperazine alkaloids, brevianamides E1 (
A new dimeric alkaloid plakoramine [(±)-1] was identified from a marine sponge Plakortis sp. Chiral-phase HPLC separation of (±)-1 led to the purified enantiomers (+)-1 and (-)-1 which both potently inhibited CBL-B E3 ubiquitin ligase activities. The absolute configurations were determined by quantum chemical calculations. Scrutinization purification conditions revealed previously undescribed, nonenzymatic route form via photochemical conversion its naturally occurring monomeric counterpart,...
Hydrogen bonding is a vital feature of large ensemble chemical structures. Soluble epoxide hydrolase (sEH) has been targeted for development the treatment inflammation-associated diseases. Compounds 1 and 2 were purified from Rubia philippinensis, their structures established via physical data analysis. Compound possesses intramolecular hydrogen bonding, sufficiently robust to transfer heteronuclear magnetization nonbonded interaction. The strength was assessed using 1H NMR shift temperature...
Plant-derived lignans have numerous biological effects including anti-tumor and anti-inflammatory activities. Screening of purified constituents Rubia philippinensis from human glioblastoma cells resistant to TNF-related apoptosis-inducing ligand (TRAIL) has suggested that the lignan pinoresinol was a highly active TRAIL sensitizer. Here we show treatment with nontoxic doses in combination induced rapid apoptosis caspase activation many types cells, but not normal astrocytes. Analyses...
In tumor necrosis factor (TNF) signaling, phosphorylation and activation of receptor interacting protein kinase 1 (RIPK1) by upstream kinases is an essential checkpoint in the suppression TNF-induced cell death. Thus, discovery pharmacological agents targeting RIPK1 may provide new strategies for improving therapeutic efficacy TNF. this study, we found that 3-O-acetylrubianol C (3AR-C), arborinane triterpenoid isolated from Rubia philippinesis, promoted apoptotic necroptotic To identify...
Background/objectives Curcuma zedoaria R. (Zingiberaceae) has been used to treat headache, fever, and hypertension-related symptoms in Asian countries, including Korea, China, Japan. We investigated whether dietary intake of a C. extract (CzE) affected atherosclerosis vivo. Materials/methods Apolipoprotein E-deficient (ApoE-/-) mice (n = 32) were fed normal diet (ND), high-cholesterol (HCD), an HCD containing CzE (100 mg/kg/day), or simvastatin (10 mg/kg/day) for 12 weeks. The...
<b>Abstract ID 103203</b> <b>Poster Board 489</b> Inositol phosphates (IPs) are regulatory molecules important in many cellular functions. Inositol-1,3,4,5,6-pentaphosphate (Ins(1,3,4,5,6)P<sub>5</sub>) and inositol hexaphosphate (IP<sub>6</sub>) interact with biological processes that highly dysregulated cancers, including telomere maintenance, DNA repair, transcription regulation, necroptosis, apoptosis resistance, chromatin structure regulation. 3,4,5,6-tetraphosphate...