A5005083738- Microwave Dielectric Ceramics Synthesis
- Ferroelectric and Piezoelectric Materials
- Chemical Synthesis and Analysis
- Synthesis and Catalytic Reactions
- Advanced ceramic materials synthesis
- Click Chemistry and Applications
- Suicide and Self-Harm Studies
- Glass properties and applications
- Digital Mental Health Interventions
- Dielectric materials and actuators
- Mental Health via Writing
- Advancements in Battery Materials
- Maternal Mental Health During Pregnancy and Postpartum
- MXene and MAX Phase Materials
- Advanced Battery Materials and Technologies
- Intracerebral and Subarachnoid Hemorrhage Research
- Electrical and Thermal Properties of Materials
- Innovations in Concrete and Construction Materials
- Enzyme-mediated dye degradation
- Homicide, Infanticide, and Child Abuse
- Vacuum and Plasma Arcs
- Neurosurgical Procedures and Complications
- Power Systems and Technologies
- Advanced Neural Network Applications
- HVDC Systems and Fault Protection
Hefei University of Technology
2019-2025
Xiangya Hospital Central South University
2022-2024
China Three Gorges Corporation (China)
2024
Hong Kong Jockey Club
2023-2024
University of Hong Kong
2023-2024
Beijing University of Chemical Technology
2022-2024
SGIDI Engineering Consulting (China)
2024
Central South University
2022
Hefei University
2020
General Research Institute for Nonferrous Metals (China)
2017-2018
Here, we report a new method that employs simple and readily available small molecule, 2-cyano-6-hydroxybenzothiazole (CBT), to selectively quench the nucleophilicity of an N-terminal Cys-containing leaving group, thereby shifting equilibrium peptidyl asparaginyl ligase (PAL)-mediated ligation toward product side. This can be applied not only N- C-terminal modifications proteins but also efficiently mediate protein-protein ligation.
As one of the key components high-voltage pulse modulators, pulse-forming lines (PFLs) are moving in direction compact, solid-state, and stable working for a relatively long time. In this paper, long-lifetime PFL, based on glass ceramic with high relative permittivity, is studied numerically experimentally. Specifically, designed low-impedance dimension parameters thick electrode coating surface glass–ceramic dielectric were optimized to decrease edge electric field enhancement which could...
Intracerebral hemorrhage (ICH) is the most devastating subtype of stroke, but effective prevention and treatment strategies are lacking. Recently, gut microbiome its metabolitesis considered to be an influencing factor stroke. However, little known about effects on ICH host metabolic activity. Therefore, we used 16S sequencing, macrogenomics sequencing untargeted metabolomics explore differences in microbial-metabolome interactions between patients with intracerebral healthy control...
Silicon (Si) shows great potential for lithium-ion batteries (LIBs) due to its high theoretical capacity and low working potential. However, intrinsic electronic conductivity large volume expansion during lithiation result in dramatic fading poor rate capability. Herein, a dual-confinement strategy is proposed improving the lithium storage properties of Si by uniformly anchoring nanoparticles within MXene/ZIF-8 derived carbon framework. In Si/MXene@C composite, tightly bond with MXene...
We report the first introduction of an ether linkage as surrogate into disulfide-rich peptides using ether-containing diaminodiacid.
Asp-based lactam cyclic peptides are considered promising drug candidates. However, using Fmoc solid-phase peptide synthesis (Fmoc-SPPS) for these also causes aspartimide formation, resulting in low yields or even failure to obtain the target peptides. Here, we developed a diaminodiacid containing an amide bond as β-carboxyl-protecting group Asp avoid formation. The practicality of this has been illustrated by cyclo[Lys9,Asp13] KIIIA7-14 and 1Y.
Background Due to their accessibility and anonymity, web-based counseling services are expanding at an unprecedented rate. One of the most prominent challenges such face is repeated users, who represent a small fraction total users but consume significant resources by continually returning system reiterating same narrative issues. A deeper understanding tailoring interventions may help improve service efficiency effectiveness. Previous studies on were mainly telephone counseling,...
Abstract Solid phase peptide synthesis (SPPS) strategy based on diaminodiacids had become an effective method for the of disulfide‐containing polypeptides. At present, it remains necessary to develop a diaminodiacid with more abundant chain structures study structure‐activity relationship. In this work, we developed new type containing six‐atom thioether (C−C‐S−C‐C−C, C−C‐C−S‐C−C) bridge. The key segment protected homo‐homocystine can be efficiently obtained by converting side carboxyl group...
Main observation and conclusion The synthesis of an Asp lactam derivative A‐183, a selective inhibitor Factor 7a with good anticoagulant antithrombotic activity, is described. Our depends on the use removable backbone modification (RBM) strategy to prevent aspartimide formation, which thwarted all attempts synthesize this target using direct solid‐phase peptide synthesis. Validation RBM in second was also accomplished. therefore proposed as general method for cyclic peptides.
Lactam cyclic peptides are a class of interesting and pharmaceutically active molecules, but their previous syntheses have required the use heavy metals and/or forcing conditions. Here, we describe efficient application previously reported tert-butyl disulfide-protected amino acids in efficient, solid-phase synthesis series lactam under mild, metal-free
Abstract In the process of pumping, segregation concrete mixture will lead to difficulty construction, and even possibility pipe blocking. There is a lack quickly evaluation for on‐site construction. order solve this problem, rapid wet‐sieved test was proposed in study then its feasibility evaluated based on mixes with different water–cement ratios. Subsequently, influence sand ratio degree investigated. The results show that combination 2.36 mm screen size 20 s vibrating time did best....
As a typical insulating material, Al2O3 serves as the signal isolation device in multi-layer ceramic NOx sensors. However, application of Al2O3-based materials is limited by co-firing compatibility between and yttria-stabilized zirconia (YSZ). In present study, green tapes with different contents γ-Al2O3 SiO2–B2O3 (Si–B) are developed to promote integration material YSZ. The sintering shrinkage obtained greatly influenced ratio α-Al2O3 at 1450 °C, e.g., maximum reaches 17.34% when 1:2....
<title>Abstract</title> Aiming at the Interior Permanent Magnet Synchronous Motor (IPMSM) which cannot be started smoothly in zero low speed range and transition to medium high a single observer, this paper proposes set of full control algorithms based on fusion pulsating frequency injection (HFI) position error information back electromotive force (EMF). When operating or start-up, square wave excitation signal is injected, obtained current processed obtain rotor information, enhances...