A5112550210- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Genomics and Phylogenetic Studies
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Animal Virus Infections Studies
- Hepatitis B Virus Studies
- Polyomavirus and related diseases
- Mycobacterium research and diagnosis
- Cancer Mechanisms and Therapy
- Complex Systems and Time Series Analysis
- Liver Disease and Transplantation
- Plant Virus Research Studies
- Stock Market Forecasting Methods
- Advanced Decision-Making Techniques
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Enzyme Production and Characterization
- Peroxisome Proliferator-Activated Receptors
- Cancer Research and Treatments
- Enzyme Structure and Function
Shihezi University
2006-2025
China Medical University
2023
Xinjiang Medical University
2015
University of Pennsylvania
2013
National Institute for Communicable Disease Control and Prevention
2011
Jilin University
2008
Liaoning Shihua University
2005
ABSTRACT Despite the worldwide distribution, most of known Seoul viruses (SEOV) are closely related to each other. In this study, M and S segment sequences SEOV were recovered from 130 lung tissue samples (mostly Norway rats) six patient serum by reverse transcription-PCR. Genetic analysis revealed that all belong represent 136 novel strains. Phylogenetic available SEOV, including Chinese strains, four distinct groups. All non-Chinese strains variants fell into phylogroup A, while...
We have identified host IQGAP1 as an interacting partner for Ebola virus (EBOV) VP40, and its expression is required EBOV VP40 virus-like particle (VLP) budding. involved in actin cytoskeletal remodeling during cell migration formation of filopodia. The physical interaction the functional requirement VLP egress link budding to machinery. Consequently, this represents a novel target development therapeutics block transmission filoviruses.
Viral metagenomics is the most powerful tool to profile viromic composition for a given sample. Different methods, including amplification-free ones, have been developed, but choosing them different purposes requires comprehensive benchmarks. Here, we assessed performance of four routinely used i.e., multiple displacement amplification (MDA), direct metagenomic sequencing (MTG), sequence-independent single-primer (SIA), and metatranscriptomic (MTT), using marmot rectal samples as templates...
(1) Background: In recent years, the increasing emergence of multidrug-resistant pathogens in pig farms has begun to pose a severe threat animal welfare and, by extension, public health. this study, we aimed explore biological characteristics and genomic features bacteriophages that are capable lysing porcine E. coli, which was isolated from sewage. doing so, provided reference for phage therapies can be used treat strains. (2) Method: Using coli isolate sq-1 as host bacterium, were purified...
Nontuberculous mycobacteria (NTM) are environmental organisms that can cause opportunistic infections in humans and animals. Mycobacterium abscessus (Mab) is a rapidly growing known for its resistance to multiple antibiotics ability respiratory, skin, mucosal infections. Understanding the distribution prevalence of NTM, particularly Mab, cattle farms slaughterhouses crucial developing effective prevention control measures. We collected swabs from various surfaces (e.g., feed troughs, sinks,...
Abstract Hepatocellular carcinoma (HCC) is the prevailing subtype of hepatocellular malignancy. While previous investigations have evidenced a robust link with programmed cell death (PCD) and tumorigenesis, comprehensive inquiry targeting relationship between multiple PCDs HCC remains scant. Our aim was to develop predictive model for different PCD patterns in order investigate their impact on survival rates, prognosis drug response rates patients. We performed functional annotation pathway...
Polyomaviruses (PyVs) are small DNA viruses carried by diverse vertebrates. The evolutionary relationships of and hosts remain largely unclear due to very limited surveillance in sympatric communities. In order investigate whether PyVs can transmit among different mammalian species identify host-switching events the field, we conducted a systematic study large collection bats (n = 1,083) from 29 communities across China which contained multiple with frequent contact. were detected 21 bat...
Enterococcus faecalis is a prevalent opportunistic pathogen associated with chicken embryonic and neonatal chick mortality, posing significant challenge in poultry farming. In the current study, E. strain EF6, isolated from recent hatchery outbreak, served as host bacterium for isolation of novel phage EFP6, capable lysing faecalis. Transmission electron microscopy revealed hexagonal head short tail, classifying EFP6 member Autographiviridae family. showed sensitivity to ultraviolet...
Klebsiella pneumoniae (K. pneumoniae) is recognized as a zoonotic pathogen with an increasing threat to livestock and poultry. However, research on K. of animal origin remains limited. To address the gap, comprehensive investigation was carried out by collecting total 311 samples from farms four species (dairy cow, chicken, sheep, pig) in selected areas Xinjiang, China. Isolates were identified khe gene amplification 16S rRNA sequencing. Genotyping pneumonia isolates performed using wzi...
Mixed infection with hepatitis E virus (HEV) in patients chronic B (HBV) is frequent. HEV mixed often leads to activation of hepatic pathological changes and worsens the inflammatory activity. However, it not known clearly how these two types influence each other human body. Intensive investigation has revealed that inhibits HBV replication. We have just encountered a relative rare case. The patient who was carrier infected by HEV. Before he HEV, measurement his DNA fixed quantity...
Abstract Background Peroxisome proliferator activating receptors (PPARs) are important regulators of nuclear hormone receptor function, and they play a key role in biological processes such as lipid metabolism, inflammation cell proliferation. However, their head neck squamous carcinoma (HNSC) is unclear. Methods We used multiple datasets, including TCGA‐HNSC, GSE41613, GSE139324, PRJEB23709 IMVigor, to perform comprehensive analysis PPAR‐related genes HNSC. Single‐cell sequencing data were...
Abstract Polyomaviruses (PyVs) are small, double-stranded DNA tumor viruses carried by diverse vertebrates. PyVs have previously been considered highly host restricted in mammalian hosts, with host-switching events thought rare or nonexistent. Prior investigations revealed short-range of two different African bat species within the horseshoe genus Rhinolophus . Herein, we conducted a systematic investigation 1,083 archived samples collected from five provinces across China, and identified...