A5046874680- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Xenotransplantation and immune response
- Animal Disease Management and Epidemiology
- Animal Genetics and Reproduction
- Virus-based gene therapy research
- Viral Infections and Outbreaks Research
- Viral Infectious Diseases and Gene Expression in Insects
- Influenza Virus Research Studies
- Aquaculture disease management and microbiota
- CRISPR and Genetic Engineering
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Folate and B Vitamins Research
- Bat Biology and Ecology Studies
- Metabolism and Genetic Disorders
- Porphyrin Metabolism and Disorders
- Respiratory viral infections research
- Polyomavirus and related diseases
- Vector-borne infectious diseases
- RNA Research and Splicing
- Parasitic Infections and Diagnostics
Guangxi Veterinary Research Institute
2014-2025
Italian Institute of Technology
2022
Turin Polytechnic University
2022
University of Ontario Institute of Technology
2022
Polytechnic University of Turin
2022
Haier Group (China)
2020
Academy of Military Medical Sciences
2008-2018
Guangxi University
2013-2018
Sun Yat-sen University
2010
Guangzhou Blood Center
2007
Alterations in homocysteine, methionine, folate, and/or B12 homeostasis have been associated with neural tube defects, cardiovascular disease, and cancer. Methionine synthase, one of only two mammalian enzymes known to require vitamin as a cofactor, lies at the intersection these metabolic pathways. This enzyme catalyzes transfer methyl group from 5-methyl-tetrahydrofolate generating tetrahydrofolate methionine. Human patients methionine synthase deficiency exhibit homocysteinemia,...
Pigs are deeply involved in human lives; hence, their viruses associated with public health. Here, we established the most comprehensive virome of healthy piglets to date, which provides a viromic baseline weaned pigs for disease prevention and control, highlighting that longitudinal monitoring is needed better understand dynamics pig development occurrence.
Human cells are known to express many chimeric RNAs, i.e. RNAs containing two genes' sequences. Wondering whether there also is trimeric RNA, an RNA three sequences, we wrote simple computer code screen human expression sequence tags (ESTs) deposited in different public databases, and obtained hundreds of putative ESTs. We then used NCBI Blast UCSC Blat browsers further analyze their identified 61 tetrameric ESTs (one EST four sequences). 57 chimeric, or teterameric that contained both...
BRM is an ATPase component of the SWI/SNF complex that regulates chromatin remodeling and cell proliferation considered a tumor suppressor. In this study we characterized transcripts from Smarca2 gene encodes protein. We found human (hSmarca2), like its mouse counterpart (mSmarca2), also initiated short transcript intron 27 long transcript. name as Smarca2-a Smarca2-b, respectively. Like counterpart, mSmarca2-a underwent alternative splicing at 54-bp exon 29. The hSmarca2-b had two...
Human cystathionine β-synthase is a hemeprotein that catalyzes pyridoxal phosphate (PLP)-dependent condensation of serine and homocysteine into cystathionine. Biophysical characterization this enzyme has led to the assignment heme ligands as histidine cysteinate, respectively, which recently been confirmed by crystal structure determination catalytic core protein. Using site-directed mutagenesis, we confirm C52 H65 represent thiolate heme. Conversion alanine or results in spectral properties...
Polyomaviruses (PyVs) are small DNA viruses carried by diverse vertebrates. The evolutionary relationships of and hosts remain largely unclear due to very limited surveillance in sympatric communities. In order investigate whether PyVs can transmit among different mammalian species identify host-switching events the field, we conducted a systematic study large collection bats (n = 1,083) from 29 communities across China which contained multiple with frequent contact. were detected 21 bat...
ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV)-specific neutralizing antibodies (NA) are important for clearing the virus. Pen-based pig oral fluid samples disease surveillance gaining in importance due to ease of collection low cost. The aim this study was develop a PRRSV-specific NA assay determine titers samples. At first, we standardized PRRSV using pen-based collected over period 3 months from herd swine that received modified live vaccine (PRRS-MLV), also used...
Bats are newly identified reservoirs of hantaviruses (HVs) among which very divergent HVs have been discovered in recent years. However, their significance for public health remains unclear since seroprevalence as well antigenic relationship with human-infecting not investigated. In the present study archived tissues 1,419 bats 22 species from 6 families collected 5 south and southwest provinces China were screened by pan-HV RT-PCR following viral metagenomic analysis. As a result nine two...
Erysipelothrix rhusiopathiae (E. rhusiopathiae) is an important pathogenic microorganism affecting swine industry. Here, we report the finished annotated genome sequence of E. GXBY-1, isolated from acute erysipelas in Binyang County, Guangxi, China. The GXBY-1 strain, which exhibits high pathogenicity for swine, contains 1,876,490 bp with G + C content 36.50%, and 1734 protein-coding genes, 57 tRNAs 27 rRNAs. nucleotide this was deposited into GenBank under accession CP014861.
Southern China is a hot spot of emerging infectious diseases, in which diverse species bats dwell, large group flying mammals considered natural reservoirs for zoonotic viruses. Recently, divergent filoviruses (FiVs) have been identified within this region, pose potential risk to public health, but the true infection situation remains largely unclear. Here, 689 archived bat serum samples were analyzed by enzyme-linked immunosorbent assay (ELISA), Western blotting, and neutralization...
Influenza A virus (IAV) and Streptococcus pneumoniae (pneumococcus) are two major upper respiratory tract pathogens responsible for exacerbated disease in coinfected individuals. Despite several studies showing increased susceptibility to secondary bacterial infections following IAV infection, information on the direct effect of S. vitro is unknown. This an important area investigation as a common commensal human tract, present coinfecting pathogen with infection. recent study showed that...