A5045177392- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Shoulder Injury and Treatment
- Congenital Heart Disease Studies
- Shoulder and Clavicle Injuries
- Neuroscience of respiration and sleep
- Trauma Management and Diagnosis
- Mechanical Circulatory Support Devices
- Congenital Anomalies and Fetal Surgery
- Nerve Injury and Rehabilitation
- Veterinary medicine and infectious diseases
- Advanced MRI Techniques and Applications
- Circadian rhythm and melatonin
- Pediatric Hepatobiliary Diseases and Treatments
- Respiratory Support and Mechanisms
- Sports injuries and prevention
- Cardiac Valve Diseases and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Tracheal and airway disorders
- Helicobacter pylori-related gastroenterology studies
- Orthopedic Surgery and Rehabilitation
- Cardiac Imaging and Diagnostics
- Salivary Gland Disorders and Functions
- Bioactive Compounds and Antitumor Agents
- Digital Radiography and Breast Imaging
University Hospital of Basel
2012-2025
Schulthess-Klinik
2024
University Hospital Bonn
2009-2023
University of Bonn
2010-2023
Uniwersytecki Szpital Dziecięcy
2023
World Health Organization
2021
Kassenärztliche Vereinigung Baden-Württemberg
2019
Beth Israel Deaconess Medical Center
2013-2014
University of Basel
2013
Norwegian University of Science and Technology
2010
We undertook a Grand Challenges in Global Eye Health prioritisation exercise to identify the key issues that must be addressed improve eye health context of an ageing population, eliminate persistent inequities health-care access, and mitigate widespread resource limitations.Drawing on methods used previous studies, we multi-step recruitment strategy assemble diverse panel individuals from range disciplines relevant global all regions globally participate three-round, online, Delphi-like,...
Pulmonary hypertension (PH) is an important contributor of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). Treatment options are limited, but sildenafil might improve oxygenation PH neonates CDH.Aim this study to assess effects intravenous on CDH.A retrospective chart review was performed all CDH born our institution between September 2012 December 2014. Indication for OI > 15, 2/3 systemic pressure, or a difference pre- postductal oxygen saturation (≥8%). A...
Abstract Pulmonary hypertension (PH) contributes to high mortality in congenital diaphragmatic hernia (CDH). A better understanding of the regulatory mechanisms underlying pathology CDH might allow identification prognostic biomarkers and potential therapeutic targets. We report results from an expression profiling circulating microRNAs (miRNAs) direct post-pulmonary blood flow 18 newborns. Seven miRNAs differentially expressed children that either died or developed chronic lung disease...
Background: Assessment of pulmonary hypertension (PH) is essential in neonates with congenital diaphragmatic hernia (CDH). Echocardiography widely established to quantify PH severity, but currently used parameters have inherent limitations. The aim our study was investigate the prognostic utility index artery acceleration time right ventricular ejection (PAAT:ET) CDH assessed using echocardiography. Methods: PAAT:ET values were prospectively measured on admission, day life (DOL) 2 and DOL...
Abstract Objective To investigate whether the pattern of flow through ductus arteriosus (DA) is associated with need for extracorporeal membrane oxygenation support (ECMO) or death in neonates congenital diaphragmatic hernia (CDH). Design Retrospective observational study. Setting German level III Neonatal Intensive Care Unit. Participants 139 CDH were born between March 2009 and May 2021. Methods DA was assessed echocardiograms obtained within 24 h life by measuring time velocity integral...
Aims Our aim was to investigate occurrence of senescent cells directly in tendon tissue biopsies from patients with chronic shoulder tendinopathies, and correlate senescence Enhancer zeste 2 (EZH2) expression, the functional subunit epigenetic master regulator polycomb repressive complex. Methods Human proximal long head biceps tendons different pathologies (n = 22), controls humerus fracture 6) pathology 4), were histologically scored for degeneration analyzed gene protein expression...
To evaluate the effect of dual-source parallel radiofrequency (RF) transmission with patient-adaptive local RF shimming on image quality, contrast, and diagnostic confidence at routine clinical cardiac magnetic resonance (MR) imaging use a 3.0-T dual-channel transmit whole-body MR system.Written informed consent was obtained from all patients, study protocol approved by institutional review board. Cardiac performed in 28 patients using unit equipped system. The conventional versus...
Helicobacter pylori (H.pylori) infection is a common medical problem in resource limited areas. The treatment outcome after triple therapy has not been well studied developing countries and preliminary data suggests high rate of failure. This study investigated the failure associated factors among dyspeptic patients receiving H. first line at tertiary hospital, Tanzania.A prospective Gastroenterology unit Bugando Medical Centre (BMC) was conducted between October 2015 May 2017. All with...
Pulmonary hypertension (PH) is one of the major contributing factors to high morbidity and mortality in neonates with congenital diaphragmatic hernia (CDH). The severity duration postnatal PH are an established risk factor for patient outcome; however, early dynamics have not been investigated. This study aims describe course CDH infants, its relation prognostic markers outcome measures.We performed a monocentric retrospective review prenatally diagnosed CDH, who received three standardized...
Infants with congenital diaphragmatic hernia frequently suffer from cardiac dysfunction and pulmonary hypertension during the postnatal course. With use of inodilator levosimendan, a therapeutic approach is available in situations catecholamine-refractory low-cardiac-output failure severe hypertension.Retrospective single-center cohort study.University-based, tertiary-care children's hospital neonatal ICU.Cohort 24 infants levosimendan therapy, without underlying major defect, treated at...
Extracorporeal membrane oxygenation (ECMO) is a widely used technique to support neonates with severe respiratory failure. Data on percutaneous, ultrasound-guided veno-venous (VV) ECMO cannulation in still scarce. Aim of this study was describe our institutional experience VV failure.Neonates receiving at department between January 2017 and 2021 were retrospectively identified. Patients performed by the percutaneous Seldinger single- or multisite analyzed.A total 54 received technique. In 39...
Abstract Objective: Echocardiography is the most important tool to assess infants with congenital diaphragmatic hernia (CDH) for pulmonary hypertension (PH). The pattern of blood flow in artery [described as time peak velocity (TPV)/right ventricular ejection (RVET) ratio] provides distinct information about arterial pressure. aim our study was investigate correlation TPV/RVET measurements commonly used classification system PH CDH newborns and association these outcome parameters. Methods:...
Abstract Objective Evaluation of course and outcome pregnancies with prenatally diagnosed fetal teratomas various locations in a single center between 2002 2019. Methods Retrospective observational single‐center study including suspected or teratomas. Focus was put on ultrasound findings during pregnancy. Complications, need for intervention outcomes were compared according to tumor location. Results 79 cases seen at our Most frequent the sacrococcygeal region (59.5%), neck (20.2%)...
Abstract Background Evidence for periconceptional or prenatal environmental risk factors the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time conception and birth, maternal BMI, parental such as smoking, alcohol drug intake, use hairspray, contact animals chronic diseases. were born between 2001 2019, all...
There remains controversy on the role of deltoid glenohumeral translations during basic and pitching motions. We thus studied passive effect joint center (GHJC).Six shoulders were tested using an automated mechanical system. A baseline motion pattern intact specimen was contrasted with translation after removal deltoid. Each condition evaluated in abduction (ABD) abbreviated throwing (ATM) retro-reflective, bone-embedded markers. The absolute trajectory area under curve (AUC) for each...
Objectives. Helicobacter pylori (H. pylori) isolates resistant to clarithromycin and quinolones are increasing worldwide. Data regarding the magnitude of H. resistance limited in developing countries. Here, we report prevalence mutations conferring fluoroquinolones among dyspeptic patients attending a tertiary hospital, Tanzania. Methods. Between August 2014 2016, undergoing upper gastrointestinal endoscopy at Bugando Medical Centre were enrolled. Biopsies taken for polymerase chain reaction...