A5045281756- Gold and Silver Nanoparticles Synthesis and Applications
- Diamond and Carbon-based Materials Research
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- Laser-Ablation Synthesis of Nanoparticles
- Hormonal Regulation and Hypertension
- Nanoplatforms for cancer theranostics
- Nutritional Studies and Diet
- Metabolomics and Mass Spectrometry Studies
- 3D Printing in Biomedical Research
- Adrenal Hormones and Disorders
- Nonlinear Optical Materials Studies
- Antioxidant Activity and Oxidative Stress
- Bone Tissue Engineering Materials
- Atherosclerosis and Cardiovascular Diseases
- Inhalation and Respiratory Drug Delivery
- Lipid Membrane Structure and Behavior
- Polymer Surface Interaction Studies
- Carbon and Quantum Dots Applications
- Extracellular vesicles in disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bone health and osteoporosis research
- Molecular Sensors and Ion Detection
- Photoreceptor and optogenetics research
- Nanocluster Synthesis and Applications
ITMO University
2020-2024
Russian Academy of Sciences
1982
Academy of Medical Sciences
1982
Heat is a well-known treatment method for wide range of diseases. Hyperthermia or intentional overheating cells rapidly developing therapeutic strategy in cancer treatment. All-dielectric nanophotonics has established itself optical applications, including nanothermometry and heating; generally, it involves Mie resonances nonplasmonic nanoparticles (NPs). However, such nanomaterials do not always provide sufficient heating due to their nonoptimal size distribution after fabrication by...
Core–shell particles made of calcium carbonate and coated with biocompatible polymers using the Layer-by-Layer technique can be considered as a unique drug-delivery platform that enables us to load different therapeutic compounds, exhibits high biocompatibility, integrate several stimuli-responsive mechanisms for drug release. However, before implementation diagnostic or purposes, such core–shell require comprehensive in vivo evaluation terms physicochemical pharmacokinetic properties....
Modified phosphatidylcholine and sphingomyelin containing an anthryl end group attached to one of the Fatty acyl chains were used as fluorescent probes in investigation molecular organization human high‐density lipoproteins (HDL). Monolayer experiments NMR measurements showed anthryl‐labeled lipids mimic closely corresponding host phospholipids, fluorophores being located near terminal CH 3 groups fatty acid residues. The above phospholipid made it possible for first time study...
Real-time temperature monitoring within biological objects is a key fundamental issue for understanding the heating process and performing remote-controlled release of bioactive compounds upon laser irradiation. The lack accurate thermal control significantly limits translation optical techniques into nanomedicine. Here, we design develop hybrid (complex) carriers based on multilayered capsules combined with nanodiamonds (NV centers) as nanothermometers gold nanoparticles (Au NPs)...
Among numerous optical sensing techniques, lifetime analysis of fluorescent agents has several advantages, including high responsivity to local environmental changes and reduced susceptibility random light-scattering events during through-tissue imaging. Monitoring ion concentrations in blood vessels is among the applications for which approaches can be particularly beneficial. However, without additional biochemical conjugation approaches, lack specificity; namely, they are either weakly...
Native Chukot Peninsula residents, in contrast to Muscovites, consume a diet rich n-3 polyunsaturated fatty acids. This dietary peculiarity is reflected differences plasma lipid and apolipoprotein contents. The residents have lower contents of total cholesterol, triglyceride, LDL (low density lipoprotein) cholesterol B, but higher HDL (high levels than do Muscovites. A-I were identical both groups. A ratio was determined the coastline (0.52 +/- 0.01) Muscovites (0.43 0.01; p less 0.01). In...
Abstract Hyperthermia plays a significant role in cancer treatment by inducing cell damage through temperature elevation, often used alongside other modalities. During hyperthermia therapy, control is crucial. Here, we report on simple synthesis route of hybrid plasmonic nanodiamonds either completely wrapped with an Au shell ( NV@Au ) or densely covered NPs NV@SiO 2 @Au ). Such integration advantageous both for heating and precise thermometry at nanoscale. After structural optical...
Abstract Accumulation of rhodamine B isothyocyanate‐conjugated low density lipoproteins (R‐LDL) in cultured endothelial cells from human umbilical cord was studied with a fluorescence activated cell sorter. R‐LDL uptake blocked at 0°C, inhibited by addition excess nonlabeled lipoprotein, high lipoprotein‐2 or lipoprotein‐3. High about twice as effective inhibition Endothelial that formed contact‐inhibited monolayer lost the ability to incorporate via receptor‐mediated pathway. Using R‐LDL,...
Optically induced hyperthermia is an actively developing approach to treating cancer. All-dielectric nanoparticles have established themselves in different biomedical applications, including optical heating and nanothermometry. However, this type of (NPs) do not provide sufficient due the necessity for a narrow size distribution. Thus, size-separation required. Other method negating disadvantages all-dielectric NPs incorporating plasmonic create hybrid nanostructure, which would be less...
Abstract Nanostructures enabling light manipulation in response to external stimuli offer unprecedented opportunities for efficient control over optomechanical systems at the nanoscale. The integration of stimuli‐responsive materials such is an important milestone creation miniaturized and smart nano‐ micromechanical systems. In this article, a thermally sensitive mechanically driven platform based on pNIPAM microspheres modified with high refractive index dielectric silicon (Si) plasmonic...
Core-shell calcium carbonate (CaCO3) particles of different sizes, and coated with biocompatible polymers via layer-by-layer method were loaded a model radionuclide 68Ga using strategies. The obtained radiolabeled characterized their biodistribution was tested after intravenous injection in rats. data demonstrate the size-dependent organ accumulation as verified positron emission tomography computerized tomography.
Accurate thermal monitoring is essential tool for photothermal therapy or application light-responsive drug delivery platforms, because overheating of living cells related with unwanted side effects in surrounding tissues. In this work, we investigated a multifunctional polymer capsule embedded nitrogen vacancies (NV) centers as nanothermometers and gold (Au) nanoparticles (NPs) heating agents to perform laser-induced release bioactive compounds from the carriers simultaneous temperature...