A5011471401- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- biodegradable polymer synthesis and properties
- Dental Implant Techniques and Outcomes
- Silk-based biomaterials and applications
- Graphene and Nanomaterials Applications
- Electrohydrodynamics and Fluid Dynamics
- Neuroscience and Neural Engineering
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Wound Healing and Treatments
- Cell Image Analysis Techniques
- Orthopaedic implants and arthroplasty
- Collagen: Extraction and Characterization
- Reconstructive Surgery and Microvascular Techniques
Sungkyunkwan University
2017-2023
Chonnam National University Hospital
2021
Wake Forest University
2019-2021
Forest Institute
2019-2021
It is well known that a nanoscale fibrous structure can provide unique stage for encouraging reasonable cell activities including attachment and proliferation owing to its similar topological the extracellular matrix. Hence, has been widely applied in tissue regeneration. Type-I collagen typically used as typical regenerative material biocompatibility abundance, although it potential antigenicity. In particular, fabricated two different forms, porous spongy nanofibers. However, structures...
Extracellular matrices (ECMs) derived from tissues and decellularized are widely used as biomaterials in tissue engineering applications because they encompass tissue-specific biological physical cues. In this study, we utilized a solubilized (dECM) obtained skeletal muscle to fabricate nanofibrous structure using the electrospinning technique. The dECM was chemically modified by methacrylate reaction (dECM-MA) improve structural stability before electrospinning. electrospun dECM-MA...
To achieve rapid skeletal muscle function restoration, many attempts have been made to bioengineer functional constructs by employing physical, biochemical, or biological cues. Here, we develop a self-aligned construct printing photo-crosslinkable extracellular matrix-derived bioink together with poly(vinyl alcohol) that contains human progenitor cells. induce the self-alignment of cells, in situ uniaxially aligned micro-topographical structure printed is created fibrillation/leaching after...
Bioengineering scaffolds have been improved to achieve efficient regeneration of various damaged tissues.In this study, we attempted fabricate mechanically and biologically activated 3D printed scaffold in which porous gelatin/hydroxyapatite (G/H) as a matrix material provided outstanding mechanical properties with recoverable behavior, human placental extracts (hPE) embedded the were used bioactive components.Methods: Various cell types (human adipose-derived stem cells; hASCs,...
The fabrication of highly porous cell-loaded structures in tissue engineering applications has been a challenging issue because non-porous cell-laden struts can cause severe cell necrosis the middle region owing to poor transport nutrients and oxygen. In this study, we propose versatile handheld 3D printer for effective methacrylated gelatin (GelMa) with high porosity (≈97%) by air injection bubble-making system using mesh filters through which mixture air/GelMa bioink is passed. particular,...
Intervertebral disc degeneration (IVDD) is a common cause of chronic low back pain (LBP) and socioeconomic burden worldwide. Conservative therapies surgical treatments provide only symptomatic relief without promoting intervertebral (IVD) regeneration. Therefore, the clinical demand for regenerative repair high.In this study, we used rat tail nucleotomy model to develop mechanically stable collagen-cryogel fibrillated collagen with shape-memory use in minimally invasive surgery effective...
Calcium phosphate cement scaffolds have been extensively used in bone tissue regeneration applications because they are similar to the inorganic components of bones and outstanding biocompatibility. However, main shortcomings ceramic their brittleness low retention level various growth factors or drugs. To overcome these shortcomings, we reinforced using synthetic natural polymers as composites. Here, designed a new bone-biomimetic composite consisting calcium deficient hydroxyapatite...
One of the most important factors in skeletal muscle tissue regeneration is alignment cells to mimic native tissue. In this study, we developed a PCL-based scaffold with uniaxially aligned surface topography by stretching 3D-printed scaffold. We examined formation patterns samples at different temperatures and rates. This was possible through effects crystalline amorphous regions on micro-textured deformation during process. characterized physical biological properties unstretched stretched...
This study examined whether neonatal chicken bone marrow cells (cBMCs) could support the osteogenesis of human stromal in a three-dimensional (3D) extracellular bioprinting niche. The majority (>95%) 4-day-old cBMCs subcultured 5 times were positive for osteochondrogenesis-related genes (Col I, Col II, X, aggrecan, Sox9, osterix, Bmp2, osteocalcin, Runx2, and osteopontin) their related proteins (Sox9, collagen type II). LC–MS/MS analysis demonstrated that cBMC-conditioned medium (c-medium)...
Shape-memory hydrogels (SMHs) have been used for various biomedical applications, such as injectable scaffolds in noninvasive procedures and carriers drugs stem cells. However, most SMH studies investigated properties related to shape recovery rather than bioactivities governed by hydrogel micro/nanostructure. In this study, one of the main structural proteins tissues organs, collagen, was incorporated into SMHs, varying fabrication procedure, two different collagen-based SMHs were obtained....
Topographical cues are one of the prerequisites for successful regeneration muscle tissue. However, fabrication methods using three-dimensional (3D) bioprinters limited by simple nozzle-based extrusion or uncontrollability photo-reactive systems. Hence, most studies on inducing topographical were focused two-dimensional (2D) surface structures, and based imprinting soft-lithography processes. Although 2D patterned surfaces provide outstanding insight into optimal architectures facilitating...